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[Association of blood pressure levels with carotid intima-media thickness and plaques].
J Prev Med Public Health 2009; 42(5):298-304JP

Abstract

OBJECTIVES

The aim of this study was to investigate the association of blood pressure levels with the common carotid artery intima-media thickness (CCA-IMT) and carotid plaques.

METHODS

Data were obtained from 2,635 subjects, aged 50 years and over, who participated in the Community Health Survey (a population-based, cross-sectional study) in Dong-gu, Gwangju city between 2007 and 2008. Participants were categorized into three groups according to blood pressure levels; normotensives (<120/80 mmHg), prehypertensives (120-139/80-89 mmHg), and hypertensives (> or =140/90 mmHg). Prehypertensives were further categorized as low prehypertensives (120-129/80-84 mmHg) and high prehypertensives (130-139/85-89 mmHg). Carotid intima-media thickness and plaques were evaluated with a high-resolution B-mode ultrasound. Statistical analyses were performed using chi-square test, ANOVA, and multiple logistic regression.

RESULTS

Prehypertensives had significantly greater maximal CCA-IMT values than normotensives, with a multivariate adjusted odds ratio of 1.78 (95% CI=1.36-2.32) for abnormal CCA-IMT (maximal CCA-IMT > or =1.0 mm), and 1.45 (95% CI=1.19-1.77) for carotid plaques. The multivariate adjusted odds ratio of low prehypertensives was 1.64 (95% CI=1.21-2.21) for abnormal CCA-IMT, and 1.30 (95% CI=1.04-1.63) for carotid plaques compared with normotensives. Subject with hypertension had higher frequency of abnormal CCA-IMT (odds ratio, 2.18; 95% CI=1.49-3.18), and carotid plaques (odds ratio, 1.98; 95% CI=1.46-2.67) compared with normotensives after adjustment for other cardiovascular risk factors.

CONCLUSIONS

Our results indicate that there is a significant increase in the prevalence of carotid atherosclerosis in subjects with prehypertension (even in low prehypertensives) compared with normotensive subjects. Further studies are required to confirm the benefits and role of carotid ultrasonography in persons with prehypertension.

Authors+Show Affiliations

Department of Preventive Medicine, College of Medicine, Seonam University.

Pub Type(s)

Journal Article

Language

kor

PubMed ID

19806002

Citation

Lee, Young Hoon, et al. "[Association of Blood Pressure Levels With Carotid Intima-media Thickness and Plaques]." Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, vol. 42, no. 5, 2009, pp. 298-304.
Lee YH, Kweon SS, Choi JS, et al. [Association of blood pressure levels with carotid intima-media thickness and plaques]. J Prev Med Public Health. 2009;42(5):298-304.
Lee, Y. H., Kweon, S. S., Choi, J. S., Rhee, J. A., Choi, S. W., Ryu, S. Y., & Shin, M. H. (2009). [Association of blood pressure levels with carotid intima-media thickness and plaques]. Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, 42(5), pp. 298-304. doi:10.3961/jpmph.2009.42.5.298.
Lee YH, et al. [Association of Blood Pressure Levels With Carotid Intima-media Thickness and Plaques]. J Prev Med Public Health. 2009;42(5):298-304. PubMed PMID: 19806002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Association of blood pressure levels with carotid intima-media thickness and plaques]. AU - Lee,Young Hoon, AU - Kweon,Sun Seog, AU - Choi,Jin Su, AU - Rhee,Jung Ae, AU - Choi,Sung Woo, AU - Ryu,So Yeon, AU - Shin,Min Ho, PY - 2009/10/7/entrez PY - 2009/10/7/pubmed PY - 2009/12/24/medline SP - 298 EP - 304 JF - Journal of preventive medicine and public health = Yebang Uihakhoe chi JO - J Prev Med Public Health VL - 42 IS - 5 N2 - OBJECTIVES: The aim of this study was to investigate the association of blood pressure levels with the common carotid artery intima-media thickness (CCA-IMT) and carotid plaques. METHODS: Data were obtained from 2,635 subjects, aged 50 years and over, who participated in the Community Health Survey (a population-based, cross-sectional study) in Dong-gu, Gwangju city between 2007 and 2008. Participants were categorized into three groups according to blood pressure levels; normotensives (<120/80 mmHg), prehypertensives (120-139/80-89 mmHg), and hypertensives (> or =140/90 mmHg). Prehypertensives were further categorized as low prehypertensives (120-129/80-84 mmHg) and high prehypertensives (130-139/85-89 mmHg). Carotid intima-media thickness and plaques were evaluated with a high-resolution B-mode ultrasound. Statistical analyses were performed using chi-square test, ANOVA, and multiple logistic regression. RESULTS: Prehypertensives had significantly greater maximal CCA-IMT values than normotensives, with a multivariate adjusted odds ratio of 1.78 (95% CI=1.36-2.32) for abnormal CCA-IMT (maximal CCA-IMT > or =1.0 mm), and 1.45 (95% CI=1.19-1.77) for carotid plaques. The multivariate adjusted odds ratio of low prehypertensives was 1.64 (95% CI=1.21-2.21) for abnormal CCA-IMT, and 1.30 (95% CI=1.04-1.63) for carotid plaques compared with normotensives. Subject with hypertension had higher frequency of abnormal CCA-IMT (odds ratio, 2.18; 95% CI=1.49-3.18), and carotid plaques (odds ratio, 1.98; 95% CI=1.46-2.67) compared with normotensives after adjustment for other cardiovascular risk factors. CONCLUSIONS: Our results indicate that there is a significant increase in the prevalence of carotid atherosclerosis in subjects with prehypertension (even in low prehypertensives) compared with normotensive subjects. Further studies are required to confirm the benefits and role of carotid ultrasonography in persons with prehypertension. SN - 1975-8375 UR - https://www.unboundmedicine.com/medline/citation/19806002/[Association_of_blood_pressure_levels_with_carotid_intima_media_thickness_and_plaques]_ L2 - https://dx.doi.org/10.3961/jpmph.2009.42.5.298 DB - PRIME DP - Unbound Medicine ER -