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Epidemiology of pancreatic cancer: an overview.
Nat Rev Gastroenterol Hepatol 2009; 6(12):699-708NR

Abstract

Pancreatic cancer, although infrequent, has an exceptionally high mortality rate, making it one of the four or five most common causes of cancer mortality in developed countries. The incidence of pancreatic cancer varies greatly across regions, which suggests roles for lifestyle factors, such as diet, or environmental factors, such as vitamin D exposure. Smoking is the most common known risk factor, and is the cause of 20-25% of all pancreatic tumors. Alcohol does not seem to be a risk factor, unless it leads to chronic pancreatitis, which is a probable risk factor. Long-standing diabetes increases the risk of pancreatic cancer, but can also be an early manifestation of pancreatic tumors. 5-10% of patients with pancreatic cancer have an underlying germline disorder, while the remaining percentage of cancer cases is thought to be caused by somatic mutations. Some individual studies suggest that mutations in various polymorphic genes can lead to small increases in the risk of pancreatic cancer, but these findings need to be replicated. Rising prevalence of smoking in developing countries, improved diagnosis and increasing population longevity are all likely to increase the global burden of pancreatic cancer in the coming decades.

Authors+Show Affiliations

Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy. sara.raimondi@ieo.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19806144

Citation

Raimondi, Sara, et al. "Epidemiology of Pancreatic Cancer: an Overview." Nature Reviews. Gastroenterology & Hepatology, vol. 6, no. 12, 2009, pp. 699-708.
Raimondi S, Maisonneuve P, Lowenfels AB. Epidemiology of pancreatic cancer: an overview. Nat Rev Gastroenterol Hepatol. 2009;6(12):699-708.
Raimondi, S., Maisonneuve, P., & Lowenfels, A. B. (2009). Epidemiology of pancreatic cancer: an overview. Nature Reviews. Gastroenterology & Hepatology, 6(12), pp. 699-708. doi:10.1038/nrgastro.2009.177.
Raimondi S, Maisonneuve P, Lowenfels AB. Epidemiology of Pancreatic Cancer: an Overview. Nat Rev Gastroenterol Hepatol. 2009;6(12):699-708. PubMed PMID: 19806144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of pancreatic cancer: an overview. AU - Raimondi,Sara, AU - Maisonneuve,Patrick, AU - Lowenfels,Albert B, Y1 - 2009/10/06/ PY - 2009/10/7/entrez PY - 2009/10/7/pubmed PY - 2010/2/5/medline SP - 699 EP - 708 JF - Nature reviews. Gastroenterology & hepatology JO - Nat Rev Gastroenterol Hepatol VL - 6 IS - 12 N2 - Pancreatic cancer, although infrequent, has an exceptionally high mortality rate, making it one of the four or five most common causes of cancer mortality in developed countries. The incidence of pancreatic cancer varies greatly across regions, which suggests roles for lifestyle factors, such as diet, or environmental factors, such as vitamin D exposure. Smoking is the most common known risk factor, and is the cause of 20-25% of all pancreatic tumors. Alcohol does not seem to be a risk factor, unless it leads to chronic pancreatitis, which is a probable risk factor. Long-standing diabetes increases the risk of pancreatic cancer, but can also be an early manifestation of pancreatic tumors. 5-10% of patients with pancreatic cancer have an underlying germline disorder, while the remaining percentage of cancer cases is thought to be caused by somatic mutations. Some individual studies suggest that mutations in various polymorphic genes can lead to small increases in the risk of pancreatic cancer, but these findings need to be replicated. Rising prevalence of smoking in developing countries, improved diagnosis and increasing population longevity are all likely to increase the global burden of pancreatic cancer in the coming decades. SN - 1759-5053 UR - https://www.unboundmedicine.com/medline/citation/19806144/Epidemiology_of_pancreatic_cancer:_an_overview_ L2 - http://dx.doi.org/10.1038/nrgastro.2009.177 DB - PRIME DP - Unbound Medicine ER -