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Risk factors for early and late onset of respiratory symptoms in babies born through meconium.
Am J Perinatol. 2010 Apr; 27(4):271-8.AJ

Abstract

We sought (1) to identify risk factors for meconium aspiration syndrome (MAS) among infants born to women whose labors were complicated by thick-consistency meconium-stained amniotic fluid (MSAF), and (2) to determine whether risk factors and infant prognosis differ according to the time of onset of respiratory distress. We performed a secondary analysis of a multicenter randomized trial of amnioinfusion (AI) for the prevention of MAS among women with thick-consistency MSAF. MAS was defined as onset of respiratory distress requiring oxygen supplementation within the first 4 hours of life. Patients with respiratory symptoms with onset at >or=4 hours were treated as a separate outcome category, "late-onset respiratory distress." We developed peripartum and intrapartum regression models to identify the risk of MAS and its subgroups. A tracing with marked abnormalities was a significant risk factor for moderate/severe MAS, but not for mild MAS or for late-onset respiratory distress. Meconium below the vocal cords and need for resuscitation immediately after birth were risk factors for mild and moderate/severe MAS as well as for late-onset respiratory distress. The risk of nonrespiratory comorbidities varied directly according to the severity of the respiratory distress. Late-onset respiratory distress shares several risk factors with MAS, as defined by Rossi et al. The two conditions may represent different manifestations of the same disease process.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Xu H
Department of Obstetrics and Gynecology, Université de Montréal/Hôpital Sainte-Justine, Montreal, Quebec, Canada.
Calvet M
No affiliation info available
Wei S
No affiliation info available
Luo ZC
No affiliation info available
Fraser WD
No affiliation info available
Amnioinfusion Study Group
No affiliation info available

MeSH

AdultAge of OnsetAsphyxia NeonatorumBody Mass IndexConfidence IntervalsFemaleGestational AgeHumansIncidenceInfant MortalityInfant, NewbornMaleMaternal AgeMeconium Aspiration SyndromeObstetric Labor ComplicationsOdds RatioPregnancyProbabilityRespiratory Distress Syndrome, NewbornRisk AssessmentSeverity of Illness IndexSurvival RateTime Factors

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

19806530

Citation

Xu, Hairong, et al. "Risk Factors for Early and Late Onset of Respiratory Symptoms in Babies Born Through Meconium." American Journal of Perinatology, vol. 27, no. 4, 2010, pp. 271-8.
Xu H, Calvet M, Wei S, et al. Risk factors for early and late onset of respiratory symptoms in babies born through meconium. Am J Perinatol. 2010;27(4):271-8.
Xu, H., Calvet, M., Wei, S., Luo, Z. C., & Fraser, W. D. (2010). Risk factors for early and late onset of respiratory symptoms in babies born through meconium. American Journal of Perinatology, 27(4), 271-8. https://doi.org/10.1055/s-0029-1241740
Xu H, et al. Risk Factors for Early and Late Onset of Respiratory Symptoms in Babies Born Through Meconium. Am J Perinatol. 2010;27(4):271-8. PubMed PMID: 19806530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for early and late onset of respiratory symptoms in babies born through meconium. AU - Xu,Hairong, AU - Calvet,Marie, AU - Wei,Shuqin, AU - Luo,Zhong-Cheng, AU - Fraser,William D, AU - ,, Y1 - 2009/10/05/ PY - 2009/10/7/entrez PY - 2009/10/7/pubmed PY - 2010/6/17/medline SP - 271 EP - 8 JF - American journal of perinatology JO - Am J Perinatol VL - 27 IS - 4 N2 - We sought (1) to identify risk factors for meconium aspiration syndrome (MAS) among infants born to women whose labors were complicated by thick-consistency meconium-stained amniotic fluid (MSAF), and (2) to determine whether risk factors and infant prognosis differ according to the time of onset of respiratory distress. We performed a secondary analysis of a multicenter randomized trial of amnioinfusion (AI) for the prevention of MAS among women with thick-consistency MSAF. MAS was defined as onset of respiratory distress requiring oxygen supplementation within the first 4 hours of life. Patients with respiratory symptoms with onset at >or=4 hours were treated as a separate outcome category, "late-onset respiratory distress." We developed peripartum and intrapartum regression models to identify the risk of MAS and its subgroups. A tracing with marked abnormalities was a significant risk factor for moderate/severe MAS, but not for mild MAS or for late-onset respiratory distress. Meconium below the vocal cords and need for resuscitation immediately after birth were risk factors for mild and moderate/severe MAS as well as for late-onset respiratory distress. The risk of nonrespiratory comorbidities varied directly according to the severity of the respiratory distress. Late-onset respiratory distress shares several risk factors with MAS, as defined by Rossi et al. The two conditions may represent different manifestations of the same disease process. SN - 1098-8785 UR - https://www.unboundmedicine.com/medline/citation/19806530/Risk_factors_for_early_and_late_onset_of_respiratory_symptoms_in_babies_born_through_meconium_ DB - PRIME DP - Unbound Medicine ER -