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Diabetes incidence associated with depression and antidepressants in the Melbourne Longitudinal Studies on Healthy Ageing (MELSHA).
Int J Geriatr Psychiatry. 2010 Jul; 25(7):688-96.IJ

Abstract

OBJECTIVE

Diabetes may be associated with depression and antidepressant medication (ADM) use, but published findings remain equivocal. The authors' aimed to determine the risk of diabetes incidence associated with baseline depression exposures (symptoms and/or ADM use).

METHODS

A prospective cohort study was conducted in a regionally representative sample of non-institutionalised older Australian people (N = 1000, aged 65 + year), who were followed up biennially between 1994 and 2004 (attrition was approximately 24%). Analyses excluded participants for prevalent diabetes at baseline, determined by self-report or specific medications. Diabetes incidence was ascertained by first self-report at any follow-up wave. Depression exposures (baseline predictors) were defined by the Psychogeriatric Assessment Scales (PAS) depression scale and ADM use, and classified as: (1) 'symptomatic' (PAS score 5+); (2) 'ADM use'; (3) 'symptomatic or ADM use'; (4) 'symptomatic and no ADM use'; (5) 'asymptomatic (PAS score <5) and ADM use' and (6) 'symptomatic and ADM use'. Covariates were demographic, lifestyle, functional health and chronic disease factors. Cox regressions were used to determined hazard ratios with 95% confidence intervals (HR [95% CI]) for diabetes incidence according to depression exposures, adjusted for significant covariates.

RESULTS

Baseline response rate was 70.3%. Depression predictors of diabetes incidence were 'symptomatic' (2.29 [1.28,4.10]), 'symptomatic or ADM use' (2.13 [1.32,3.44]) and 'symptomatic and no ADM use' (2.38 [1.28,4.45]), after adjustment for significant covariates. Being asymptomatic was not a protective factor among those prescribed antidepressants.

CONCLUSIONS

Older people with depressive symptoms are at least twice more likely to develop diabetes than those without depressive symptoms, regardless of antidepressants.

Authors+Show Affiliations

Ageing, Work, and Health Research Unit, Faculty of Health Sciences, The University of Sydney, Sydney, Australia. evan.atlantis@adelaide.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19806604

Citation

Atlantis, Evan, et al. "Diabetes Incidence Associated With Depression and Antidepressants in the Melbourne Longitudinal Studies On Healthy Ageing (MELSHA)." International Journal of Geriatric Psychiatry, vol. 25, no. 7, 2010, pp. 688-96.
Atlantis E, Browning C, Sims J, et al. Diabetes incidence associated with depression and antidepressants in the Melbourne Longitudinal Studies on Healthy Ageing (MELSHA). Int J Geriatr Psychiatry. 2010;25(7):688-96.
Atlantis, E., Browning, C., Sims, J., & Kendig, H. (2010). Diabetes incidence associated with depression and antidepressants in the Melbourne Longitudinal Studies on Healthy Ageing (MELSHA). International Journal of Geriatric Psychiatry, 25(7), 688-96. https://doi.org/10.1002/gps.2409
Atlantis E, et al. Diabetes Incidence Associated With Depression and Antidepressants in the Melbourne Longitudinal Studies On Healthy Ageing (MELSHA). Int J Geriatr Psychiatry. 2010;25(7):688-96. PubMed PMID: 19806604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes incidence associated with depression and antidepressants in the Melbourne Longitudinal Studies on Healthy Ageing (MELSHA). AU - Atlantis,Evan, AU - Browning,Colette, AU - Sims,Jane, AU - Kendig,Hal, PY - 2009/10/7/entrez PY - 2009/10/7/pubmed PY - 2011/2/1/medline SP - 688 EP - 96 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 25 IS - 7 N2 - OBJECTIVE: Diabetes may be associated with depression and antidepressant medication (ADM) use, but published findings remain equivocal. The authors' aimed to determine the risk of diabetes incidence associated with baseline depression exposures (symptoms and/or ADM use). METHODS: A prospective cohort study was conducted in a regionally representative sample of non-institutionalised older Australian people (N = 1000, aged 65 + year), who were followed up biennially between 1994 and 2004 (attrition was approximately 24%). Analyses excluded participants for prevalent diabetes at baseline, determined by self-report or specific medications. Diabetes incidence was ascertained by first self-report at any follow-up wave. Depression exposures (baseline predictors) were defined by the Psychogeriatric Assessment Scales (PAS) depression scale and ADM use, and classified as: (1) 'symptomatic' (PAS score 5+); (2) 'ADM use'; (3) 'symptomatic or ADM use'; (4) 'symptomatic and no ADM use'; (5) 'asymptomatic (PAS score <5) and ADM use' and (6) 'symptomatic and ADM use'. Covariates were demographic, lifestyle, functional health and chronic disease factors. Cox regressions were used to determined hazard ratios with 95% confidence intervals (HR [95% CI]) for diabetes incidence according to depression exposures, adjusted for significant covariates. RESULTS: Baseline response rate was 70.3%. Depression predictors of diabetes incidence were 'symptomatic' (2.29 [1.28,4.10]), 'symptomatic or ADM use' (2.13 [1.32,3.44]) and 'symptomatic and no ADM use' (2.38 [1.28,4.45]), after adjustment for significant covariates. Being asymptomatic was not a protective factor among those prescribed antidepressants. CONCLUSIONS: Older people with depressive symptoms are at least twice more likely to develop diabetes than those without depressive symptoms, regardless of antidepressants. SN - 1099-1166 UR - https://www.unboundmedicine.com/medline/citation/19806604/Diabetes_incidence_associated_with_depression_and_antidepressants_in_the_Melbourne_Longitudinal_Studies_on_Healthy_Ageing__MELSHA__ L2 - https://doi.org/10.1002/gps.2409 DB - PRIME DP - Unbound Medicine ER -