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Anti-inflammatory and antinociceptive effects of Baccharis dracunculifolia DC (Asteraceae) in different experimental models.
J Ethnopharmacol. 2010 Feb 03; 127(2):543-50.JE

Abstract

AIM OF THE STUDY

The aerial parts of Baccharis dracunculifolia D.C., popularly known as "alecrim do campo", are used in folk medicine as anti-inflammatory. The aim of the present study was to evaluate the anti-inflammatory and antinociceptive activities of the crude hydroalcoholic extract obtained from leaves of Baccharis dracunculifolia (BdE), which have not been reported.

MATERIALS AND METHODS

BdE was analyzed by HPLC and in vivo evaluated (doses ranging from 50 to 400mg/kg, p.o.) by using the acetic acid-induced abdominal constrictions, paw oedema induced by carrageenan or histamine, overt nociception models using capsaicin, glutamate or phorbol myristate acetate (PMA), formalin-induced nociception and mechanical hypernociception induced by carrageenan or complete Freund adjuvant (CFA). As positive controls it was used paracetamol in both acetic acid and formalin tests; dipyrone in capsaicin, glutamate and PMA-induced nociception; indomethacin in CFA and carrageenan-induced hypernociception models. In addition, the in vitro effects of BdE on COX-2 activity and on the activation of NF-kappaB were also evaluated.

RESULTS

BdE (50-400mg/kg, p.o.) significantly diminished the abdominal constrictions induced by acetic acid, glutamate and CFA. Furthermore, BdE also inhibited the nociceptive responses in both phases of formalin-induced nociception. BdE, administered orally, also produced a long-lasting anti-hypernociceptive effect in the acute model of inflammatory pain induced by carrageenan. It was also observed the inhibition of COX-2 activity by BdE.

CONCLUSION

In summary, the data reported in this work confirmed the traditional anti-inflammatory indications of Baccharis dracunculifolia leaves and provided biological evidences that Baccharis dracunculifolia, like Brazilian green propolis, possess antinociceptive and anti-inflammatory activities.

Links

Publisher Full Text

Authors+Show Affiliations

dos Santos DA
Mestrado em Ciências Farmacêuticas, CCS, Universidade do Vale do Itajaí, Itajaí, SC, Brazil.
Fukui Mde J
No affiliation info available
Dhammika Nanayakkara NP
No affiliation info available
Khan SI
No affiliation info available
Sousa JP
No affiliation info available
Bastos JK
No affiliation info available
Andrade SF
No affiliation info available
da Silva Filho AA
No affiliation info available
Quintão NL
No affiliation info available

MeSH

AnimalsAnti-Inflammatory Agents, Non-SteroidalAsteraceaeBaccharisDisease Models, AnimalDose-Response Relationship, DrugEdemaMaleMicePainPain MeasurementPlant ExtractsPlant LeavesRatsRats, Wistar

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19808087

Citation

dos Santos, Diogo A., et al. "Anti-inflammatory and Antinociceptive Effects of Baccharis Dracunculifolia DC (Asteraceae) in Different Experimental Models." Journal of Ethnopharmacology, vol. 127, no. 2, 2010, pp. 543-50.
dos Santos DA, Fukui Mde J, Dhammika Nanayakkara NP, et al. Anti-inflammatory and antinociceptive effects of Baccharis dracunculifolia DC (Asteraceae) in different experimental models. J Ethnopharmacol. 2010;127(2):543-50.
dos Santos, D. A., Fukui, M. d. e. . J., Dhammika Nanayakkara, N. P., Khan, S. I., Sousa, J. P., Bastos, J. K., Andrade, S. F., da Silva Filho, A. A., & Quintão, N. L. (2010). Anti-inflammatory and antinociceptive effects of Baccharis dracunculifolia DC (Asteraceae) in different experimental models. Journal of Ethnopharmacology, 127(2), 543-50. https://doi.org/10.1016/j.jep.2009.09.061
dos Santos DA, et al. Anti-inflammatory and Antinociceptive Effects of Baccharis Dracunculifolia DC (Asteraceae) in Different Experimental Models. J Ethnopharmacol. 2010 Feb 3;127(2):543-50. PubMed PMID: 19808087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and antinociceptive effects of Baccharis dracunculifolia DC (Asteraceae) in different experimental models. AU - dos Santos,Diogo A, AU - Fukui,Murilo de J, AU - Dhammika Nanayakkara,N P, AU - Khan,Shabana I, AU - Sousa,João Paulo B, AU - Bastos,Jairo K, AU - Andrade,Sérgio F, AU - da Silva Filho,Ademar A, AU - Quintão,Nara L M, Y1 - 2009/10/04/ PY - 2009/07/08/received PY - 2009/09/24/revised PY - 2009/09/26/accepted PY - 2009/10/8/entrez PY - 2009/10/8/pubmed PY - 2010/9/9/medline SP - 543 EP - 50 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 127 IS - 2 N2 - AIM OF THE STUDY: The aerial parts of Baccharis dracunculifolia D.C., popularly known as "alecrim do campo", are used in folk medicine as anti-inflammatory. The aim of the present study was to evaluate the anti-inflammatory and antinociceptive activities of the crude hydroalcoholic extract obtained from leaves of Baccharis dracunculifolia (BdE), which have not been reported. MATERIALS AND METHODS: BdE was analyzed by HPLC and in vivo evaluated (doses ranging from 50 to 400mg/kg, p.o.) by using the acetic acid-induced abdominal constrictions, paw oedema induced by carrageenan or histamine, overt nociception models using capsaicin, glutamate or phorbol myristate acetate (PMA), formalin-induced nociception and mechanical hypernociception induced by carrageenan or complete Freund adjuvant (CFA). As positive controls it was used paracetamol in both acetic acid and formalin tests; dipyrone in capsaicin, glutamate and PMA-induced nociception; indomethacin in CFA and carrageenan-induced hypernociception models. In addition, the in vitro effects of BdE on COX-2 activity and on the activation of NF-kappaB were also evaluated. RESULTS: BdE (50-400mg/kg, p.o.) significantly diminished the abdominal constrictions induced by acetic acid, glutamate and CFA. Furthermore, BdE also inhibited the nociceptive responses in both phases of formalin-induced nociception. BdE, administered orally, also produced a long-lasting anti-hypernociceptive effect in the acute model of inflammatory pain induced by carrageenan. It was also observed the inhibition of COX-2 activity by BdE. CONCLUSION: In summary, the data reported in this work confirmed the traditional anti-inflammatory indications of Baccharis dracunculifolia leaves and provided biological evidences that Baccharis dracunculifolia, like Brazilian green propolis, possess antinociceptive and anti-inflammatory activities. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19808087/Anti_inflammatory_and_antinociceptive_effects_of_Baccharis_dracunculifolia_DC__Asteraceae__in_different_experimental_models_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(09)00640-0 DB - PRIME DP - Unbound Medicine ER -