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Eosinophil count is positively correlated with albumin excretion rate in men with type 2 diabetes.
Clin J Am Soc Nephrol. 2009 Nov; 4(11):1761-5.CJ

Abstract

BACKGROUND AND OBJECTIVES

Patients with allergic disorders such as allergic rhinitis or asthma have been reported to be at increased risk for atherosclerosis. In this study, we evaluated the relationships between peripheral eosinophil count and degree of albumin excretion rate, which is a useful marker of cardiovascular mortality as well as diabetic nephropathy in patients with type 2 diabetes.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS

We evaluated relationships of peripheral eosinophil count to degree of albumin excretion rate as well as to major cardiovascular risk factors, including age, BP, serum lipid concentration, and glycemic control (glycosylated hemoglobin); body mass index; current treatment for diabetes; smoking status; and presence of cardiovascular disease in 783 patients (416 men and 367 women) with type 2 diabetes.

RESULTS

Log(eosinophil count) was positively associated with systolic BP (r = 0.124, P = 0.0108), serum triglyceride concentration (r = 0.108, P = 0.0284), and log(albumin excretion rate) (r = 0.301, P < 0.0001) in men; however, no association was found between log(eosinophil count) and log(albumin excretion rate) (r = 0.085, P = 0.1050) in women. Multivariate linear regression analysis demonstrated that log(eosinophil count) (beta = 0.260, P < 0.0001), duration of diabetes (beta = 0.203, P = 0.0003), glycosylated hemoglobin (beta = 0.117, P = 0.0238), systolic BP (beta = 0.205, P = 0.0001), and serum triglyceride concentration (beta = 0.162, P = 0.0038) were independent determinants of log(albumin excretion rate) in men.

CONCLUSIONS

Allergic disorders may be associated with microalbuminuria in men with type 2 diabetes.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. sayarinapm@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19808222

Citation

Fukui, Michiaki, et al. "Eosinophil Count Is Positively Correlated With Albumin Excretion Rate in Men With Type 2 Diabetes." Clinical Journal of the American Society of Nephrology : CJASN, vol. 4, no. 11, 2009, pp. 1761-5.
Fukui M, Tanaka M, Hamaguchi M, et al. Eosinophil count is positively correlated with albumin excretion rate in men with type 2 diabetes. Clin J Am Soc Nephrol. 2009;4(11):1761-5.
Fukui, M., Tanaka, M., Hamaguchi, M., Senmaru, T., Sakabe, K., Shiraishi, E., Harusato, I., Yamazaki, M., Hasegawa, G., & Nakamura, N. (2009). Eosinophil count is positively correlated with albumin excretion rate in men with type 2 diabetes. Clinical Journal of the American Society of Nephrology : CJASN, 4(11), 1761-5. https://doi.org/10.2215/CJN.03330509
Fukui M, et al. Eosinophil Count Is Positively Correlated With Albumin Excretion Rate in Men With Type 2 Diabetes. Clin J Am Soc Nephrol. 2009;4(11):1761-5. PubMed PMID: 19808222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eosinophil count is positively correlated with albumin excretion rate in men with type 2 diabetes. AU - Fukui,Michiaki, AU - Tanaka,Muhei, AU - Hamaguchi,Masahide, AU - Senmaru,Takafumi, AU - Sakabe,Kazumi, AU - Shiraishi,Emi, AU - Harusato,Ichiko, AU - Yamazaki,Masahiro, AU - Hasegawa,Goji, AU - Nakamura,Naoto, Y1 - 2009/10/01/ PY - 2009/10/8/entrez PY - 2009/10/8/pubmed PY - 2010/2/18/medline SP - 1761 EP - 5 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 4 IS - 11 N2 - BACKGROUND AND OBJECTIVES: Patients with allergic disorders such as allergic rhinitis or asthma have been reported to be at increased risk for atherosclerosis. In this study, we evaluated the relationships between peripheral eosinophil count and degree of albumin excretion rate, which is a useful marker of cardiovascular mortality as well as diabetic nephropathy in patients with type 2 diabetes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We evaluated relationships of peripheral eosinophil count to degree of albumin excretion rate as well as to major cardiovascular risk factors, including age, BP, serum lipid concentration, and glycemic control (glycosylated hemoglobin); body mass index; current treatment for diabetes; smoking status; and presence of cardiovascular disease in 783 patients (416 men and 367 women) with type 2 diabetes. RESULTS: Log(eosinophil count) was positively associated with systolic BP (r = 0.124, P = 0.0108), serum triglyceride concentration (r = 0.108, P = 0.0284), and log(albumin excretion rate) (r = 0.301, P < 0.0001) in men; however, no association was found between log(eosinophil count) and log(albumin excretion rate) (r = 0.085, P = 0.1050) in women. Multivariate linear regression analysis demonstrated that log(eosinophil count) (beta = 0.260, P < 0.0001), duration of diabetes (beta = 0.203, P = 0.0003), glycosylated hemoglobin (beta = 0.117, P = 0.0238), systolic BP (beta = 0.205, P = 0.0001), and serum triglyceride concentration (beta = 0.162, P = 0.0038) were independent determinants of log(albumin excretion rate) in men. CONCLUSIONS: Allergic disorders may be associated with microalbuminuria in men with type 2 diabetes. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/19808222/Eosinophil_count_is_positively_correlated_with_albumin_excretion_rate_in_men_with_type_2_diabetes_ L2 - https://cjasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=19808222 DB - PRIME DP - Unbound Medicine ER -