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Body mass index and waist circumference predict both 10-year nonfatal and fatal cardiovascular disease risk: study conducted in 20,000 Dutch men and women aged 20-65 years.
Eur J Cardiovasc Prev Rehabil. 2009 Dec; 16(6):729-34.EJ

Abstract

AIMS

Body mass index (BMI) and waist circumference (WC) are both predictors of cardiovascular diseases (CVD). We compared absolute risk, hazard ratio (HR), and population attributable risk of nonfatal and fatal CVD for BMI and WC in a large prospective cohort study with an average follow-up of 10 years.

METHODS AND RESULTS

Anthropometric data were measured between 1993 and 1997 in a general population sample of over 20,000 men and women aged 20-65 years in the Netherlands. All risks were adjusted for age and sex. Absolute risk of nonfatal CVD was on average 10 times higher than that of fatal CVD. In obese respondents (BMI >or=30 kg/m2), relative risk of fatal CVD was four-fold higher [HR=4.0 95% confidence interval (CI)=2.4-6.6], whereas risk of nonfatal CVD was two-fold higher (HR=1.8 95% CI=1.6-2.2) than in normal-weight respondents. Similar associations were observed for WC (>or=88 vs. <80 cm in women and >or=102 vs. 94 cm in men). In persons with overweight or obesity (BMI >or=25 kg/m2), half of all fatal CVD (attributable risk=54%, 95% CI=30-70) and a quarter of nonfatal CVD was ascribed to their overweight. On the population level, one-third of all fatal CVD cases could be attributed to overweight and obesity (population attributable risk=35%, 95% CI=14-52), and about one in seven of nonfatal CVD cases.

CONCLUSION

The associations of BMI and WC with CVD risk were equally strong. Overweight and obesity had a stronger impact on fatal CVD than on nonfatal CVD.

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  • Publisher Full Text (DOI)
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    Authors+Show Affiliations

    van Dis I
    Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands. i.van.dis@hartstichting.nl
    Kromhout D
    No affiliation info available
    Geleijnse JM
    No affiliation info available
    Boer JM
    No affiliation info available
    Verschuren WM
    No affiliation info available

    MeSH

    AdultAge FactorsAgedBody Mass IndexCardiovascular DiseasesFemaleHumansIncidenceLinear ModelsMaleMiddle AgedNetherlandsObesityOverweightPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSex FactorsTime FactorsWaist CircumferenceYoung Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19809330

    Citation

    van Dis, Ineke, et al. "Body Mass Index and Waist Circumference Predict Both 10-year Nonfatal and Fatal Cardiovascular Disease Risk: Study Conducted in 20,000 Dutch Men and Women Aged 20-65 Years." European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, vol. 16, no. 6, 2009, pp. 729-34.
    van Dis I, Kromhout D, Geleijnse JM, et al. Body mass index and waist circumference predict both 10-year nonfatal and fatal cardiovascular disease risk: study conducted in 20,000 Dutch men and women aged 20-65 years. Eur J Cardiovasc Prev Rehabil. 2009;16(6):729-34.
    van Dis, I., Kromhout, D., Geleijnse, J. M., Boer, J. M., & Verschuren, W. M. (2009). Body mass index and waist circumference predict both 10-year nonfatal and fatal cardiovascular disease risk: study conducted in 20,000 Dutch men and women aged 20-65 years. European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 16(6), 729-34. https://doi.org/10.1097/HJR.0b013e328331dfc0
    van Dis I, et al. Body Mass Index and Waist Circumference Predict Both 10-year Nonfatal and Fatal Cardiovascular Disease Risk: Study Conducted in 20,000 Dutch Men and Women Aged 20-65 Years. Eur J Cardiovasc Prev Rehabil. 2009;16(6):729-34. PubMed PMID: 19809330.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Body mass index and waist circumference predict both 10-year nonfatal and fatal cardiovascular disease risk: study conducted in 20,000 Dutch men and women aged 20-65 years. AU - van Dis,Ineke, AU - Kromhout,Daan, AU - Geleijnse,Johanna M, AU - Boer,Jolanda M A, AU - Verschuren,W M Monique, PY - 2009/10/8/entrez PY - 2009/10/8/pubmed PY - 2010/3/2/medline SP - 729 EP - 34 JF - European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology JO - Eur J Cardiovasc Prev Rehabil VL - 16 IS - 6 N2 - AIMS: Body mass index (BMI) and waist circumference (WC) are both predictors of cardiovascular diseases (CVD). We compared absolute risk, hazard ratio (HR), and population attributable risk of nonfatal and fatal CVD for BMI and WC in a large prospective cohort study with an average follow-up of 10 years. METHODS AND RESULTS: Anthropometric data were measured between 1993 and 1997 in a general population sample of over 20,000 men and women aged 20-65 years in the Netherlands. All risks were adjusted for age and sex. Absolute risk of nonfatal CVD was on average 10 times higher than that of fatal CVD. In obese respondents (BMI >or=30 kg/m2), relative risk of fatal CVD was four-fold higher [HR=4.0 95% confidence interval (CI)=2.4-6.6], whereas risk of nonfatal CVD was two-fold higher (HR=1.8 95% CI=1.6-2.2) than in normal-weight respondents. Similar associations were observed for WC (>or=88 vs. <80 cm in women and >or=102 vs. 94 cm in men). In persons with overweight or obesity (BMI >or=25 kg/m2), half of all fatal CVD (attributable risk=54%, 95% CI=30-70) and a quarter of nonfatal CVD was ascribed to their overweight. On the population level, one-third of all fatal CVD cases could be attributed to overweight and obesity (population attributable risk=35%, 95% CI=14-52), and about one in seven of nonfatal CVD cases. CONCLUSION: The associations of BMI and WC with CVD risk were equally strong. Overweight and obesity had a stronger impact on fatal CVD than on nonfatal CVD. SN - 1741-8275 UR - https://www.unboundmedicine.com/medline/citation/19809330/Body_mass_index_and_waist_circumference_predict_both_10_year_nonfatal_and_fatal_cardiovascular_disease_risk:_study_conducted_in_20000_Dutch_men_and_women_aged_20_65_years_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=19809330.ui DB - PRIME DP - Unbound Medicine ER -