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Interaction of adipokines and hepatitis B virus on histological liver injury in the Chinese.
Am J Gastroenterol. 2010 Jan; 105(1):132-8.AJ

Abstract

OBJECTIVES

Chronic hepatitis B patients with diabetes and metabolic syndrome are at increased risk of cirrhosis and hepatocellular carcinoma, but the underlying mechanism is unclear. Our objective was to test whether dysregulation of adipokines contributes to liver injury. We also studied whether viral factors affected adipokines, insulin resistance, and hepatic steatosis.

METHODS

A prospective cohort of 266 chronic hepatitis B patients undergoing liver biopsy was studied. Fasting blood was taken for the analysis of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), adiponectin, leptin, and resistin. Insulin resistance was assessed by the homeostasis model assessment of insulin resistance (HOMA-IR). Factors associated with significant necroinflammation and cirrhosis were identified.

RESULTS

Histological activity index was correlated with serum TNF-alpha (R=0.40, P<0.0001) and IL-6 (R=0.32, P<0.0001) but not with adiponectin, leptin, or resistin. By multivariate analysis, TNF-alpha was associated with significant necroinflammation after adjusting for age and viral factors (odds ratio (OR) 1.041, 95% confidence interval (CI) 1.002-1.082, P=0.04). Serum adiponectin had positive correlation with hepatitis B virus DNA (R=0.17, P=0.007) and was decreased in patients with insulin resistance and hepatic steatosis. On the other hand, viral load, hepatitis B e-antigen status, and genotypes had no association with insulin resistance, hepatic steatosis, and the levels of TNF-alpha and IL-6. A total of 68 (25.6%) patients had cirrhosis. HOMA-IR, but not adipokine dysregulation, was independently associated with cirrhosis (OR 1.09, 95% CI 1.02-1.15, P=0.006).

CONCLUSIONS

TNF-alpha and/or IL-6 contribute to hepatic necroinflammation in chronic hepatitis B patients. Adiponectin protects against insulin resistance and hepatic steatosis but does not affect liver injury. Adipokines and viral factors contribute to liver injury independently.

Authors+Show Affiliations

Institute of Digestive Disease, The Chinese University of Hong Kong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19809411

Citation

Wong, Vincent Wai-Sun, et al. "Interaction of Adipokines and Hepatitis B Virus On Histological Liver Injury in the Chinese." The American Journal of Gastroenterology, vol. 105, no. 1, 2010, pp. 132-8.
Wong VW, Wong GL, Yu J, et al. Interaction of adipokines and hepatitis B virus on histological liver injury in the Chinese. Am J Gastroenterol. 2010;105(1):132-8.
Wong, V. W., Wong, G. L., Yu, J., Choi, P. C., Chan, A. W., Chan, H. Y., Chu, E. S., Cheng, A. S., Chim, A. M., Chan, F. K., Sung, J. J., & Chan, H. L. (2010). Interaction of adipokines and hepatitis B virus on histological liver injury in the Chinese. The American Journal of Gastroenterology, 105(1), 132-8. https://doi.org/10.1038/ajg.2009.560
Wong VW, et al. Interaction of Adipokines and Hepatitis B Virus On Histological Liver Injury in the Chinese. Am J Gastroenterol. 2010;105(1):132-8. PubMed PMID: 19809411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of adipokines and hepatitis B virus on histological liver injury in the Chinese. AU - Wong,Vincent Wai-Sun, AU - Wong,Grace Lai-Hung, AU - Yu,Jun, AU - Choi,Paul Cheung-Lung, AU - Chan,Anthony Wing-Hung, AU - Chan,Hoi-Yun, AU - Chu,Eagle Siu-Hong, AU - Cheng,Alfred Sze-Lok, AU - Chim,Angel Mei-Ling, AU - Chan,Francis Ka-Leung, AU - Sung,Joseph Jao-Yiu, AU - Chan,Henry Lik-Yuen, Y1 - 2009/10/06/ PY - 2009/10/8/entrez PY - 2009/10/8/pubmed PY - 2010/2/26/medline SP - 132 EP - 8 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 105 IS - 1 N2 - OBJECTIVES: Chronic hepatitis B patients with diabetes and metabolic syndrome are at increased risk of cirrhosis and hepatocellular carcinoma, but the underlying mechanism is unclear. Our objective was to test whether dysregulation of adipokines contributes to liver injury. We also studied whether viral factors affected adipokines, insulin resistance, and hepatic steatosis. METHODS: A prospective cohort of 266 chronic hepatitis B patients undergoing liver biopsy was studied. Fasting blood was taken for the analysis of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), adiponectin, leptin, and resistin. Insulin resistance was assessed by the homeostasis model assessment of insulin resistance (HOMA-IR). Factors associated with significant necroinflammation and cirrhosis were identified. RESULTS: Histological activity index was correlated with serum TNF-alpha (R=0.40, P<0.0001) and IL-6 (R=0.32, P<0.0001) but not with adiponectin, leptin, or resistin. By multivariate analysis, TNF-alpha was associated with significant necroinflammation after adjusting for age and viral factors (odds ratio (OR) 1.041, 95% confidence interval (CI) 1.002-1.082, P=0.04). Serum adiponectin had positive correlation with hepatitis B virus DNA (R=0.17, P=0.007) and was decreased in patients with insulin resistance and hepatic steatosis. On the other hand, viral load, hepatitis B e-antigen status, and genotypes had no association with insulin resistance, hepatic steatosis, and the levels of TNF-alpha and IL-6. A total of 68 (25.6%) patients had cirrhosis. HOMA-IR, but not adipokine dysregulation, was independently associated with cirrhosis (OR 1.09, 95% CI 1.02-1.15, P=0.006). CONCLUSIONS: TNF-alpha and/or IL-6 contribute to hepatic necroinflammation in chronic hepatitis B patients. Adiponectin protects against insulin resistance and hepatic steatosis but does not affect liver injury. Adipokines and viral factors contribute to liver injury independently. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/19809411/Interaction_of_adipokines_and_hepatitis_B_virus_on_histological_liver_injury_in_the_Chinese_ L2 - http://Insights.ovid.com/pubmed?pmid=19809411 DB - PRIME DP - Unbound Medicine ER -