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Ulcerative colitis and pregnancy outcomes in an Asian population.
Am J Gastroenterol. 2010 Feb; 105(2):387-94.AJ

Abstract

OBJECTIVES

As the prevalence of ulcerative colitis (UC) is much higher in Western countries than in Asian countries, previous investigations of pregnancy outcomes for women with UC were limited to people of European descent. This study was aimed at examining the risk of adverse pregnancy outcomes (low birth weight (LBW), preterm birth, small for gestational age (SGA), and cesarean section (CS)) among Asian women with UC.

METHODS

Using a 3-year nationwide population-based database, we identified a total of 196 women who gave birth from 2001 to 2003, who were diagnosed with UC within 2 years before their index deliveries. A total of 1,568 unaffected pregnant women matched these cases according to age and year of delivery. Conditional logistic regression analyses were performed to estimate risk.

RESULTS

There were significant differences between women with and without UC in terms of LBW (12.76% vs. 5.55, P<0.001) and preterm births (11.73% vs. 6.25%, P=0.004). After adjusting for infant gender, parity, maternal age, highest maternal educational level, parental age difference, maternal marital status, hypertension, diabetes, anemia, family monthly income, as well as conditioning on maternal age and year of delivery, the odds of LBW and preterm births for women with UC were 2.36 (95% confidence interval (CI)=1.45-3.82) and 1.90 (95% CI=1.16-3.11) times, respectively, those for unaffected women.

CONCLUSIONS

Although UC often follows a milder disease course in Asians than in people of European descent, we demonstrated that Asian women suffering from UC were still at risk of having preterm and LBW babies, compared with unaffected mothers.

Authors+Show Affiliations

School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19809415

Citation

Lin, Herng-Ching, et al. "Ulcerative Colitis and Pregnancy Outcomes in an Asian Population." The American Journal of Gastroenterology, vol. 105, no. 2, 2010, pp. 387-94.
Lin HC, Chiu CC, Chen SF, et al. Ulcerative colitis and pregnancy outcomes in an Asian population. Am J Gastroenterol. 2010;105(2):387-94.
Lin, H. C., Chiu, C. C., Chen, S. F., Lou, H. Y., Chiu, W. T., & Chen, Y. H. (2010). Ulcerative colitis and pregnancy outcomes in an Asian population. The American Journal of Gastroenterology, 105(2), 387-94. https://doi.org/10.1038/ajg.2009.562
Lin HC, et al. Ulcerative Colitis and Pregnancy Outcomes in an Asian Population. Am J Gastroenterol. 2010;105(2):387-94. PubMed PMID: 19809415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ulcerative colitis and pregnancy outcomes in an Asian population. AU - Lin,Herng-Ching, AU - Chiu,Ching-Che Jason, AU - Chen,Shu-Fen, AU - Lou,Horng-Yuan, AU - Chiu,Wen-Ta, AU - Chen,Yi-Hua, Y1 - 2009/10/06/ PY - 2009/10/8/entrez PY - 2009/10/8/pubmed PY - 2010/3/24/medline SP - 387 EP - 94 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 105 IS - 2 N2 - OBJECTIVES: As the prevalence of ulcerative colitis (UC) is much higher in Western countries than in Asian countries, previous investigations of pregnancy outcomes for women with UC were limited to people of European descent. This study was aimed at examining the risk of adverse pregnancy outcomes (low birth weight (LBW), preterm birth, small for gestational age (SGA), and cesarean section (CS)) among Asian women with UC. METHODS: Using a 3-year nationwide population-based database, we identified a total of 196 women who gave birth from 2001 to 2003, who were diagnosed with UC within 2 years before their index deliveries. A total of 1,568 unaffected pregnant women matched these cases according to age and year of delivery. Conditional logistic regression analyses were performed to estimate risk. RESULTS: There were significant differences between women with and without UC in terms of LBW (12.76% vs. 5.55, P<0.001) and preterm births (11.73% vs. 6.25%, P=0.004). After adjusting for infant gender, parity, maternal age, highest maternal educational level, parental age difference, maternal marital status, hypertension, diabetes, anemia, family monthly income, as well as conditioning on maternal age and year of delivery, the odds of LBW and preterm births for women with UC were 2.36 (95% confidence interval (CI)=1.45-3.82) and 1.90 (95% CI=1.16-3.11) times, respectively, those for unaffected women. CONCLUSIONS: Although UC often follows a milder disease course in Asians than in people of European descent, we demonstrated that Asian women suffering from UC were still at risk of having preterm and LBW babies, compared with unaffected mothers. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/19809415/Ulcerative_colitis_and_pregnancy_outcomes_in_an_Asian_population_ L2 - https://Insights.ovid.com/pubmed?pmid=19809415 DB - PRIME DP - Unbound Medicine ER -