Tags

Type your tag names separated by a space and hit enter

Ulcer healing properties of ethanolic extract of Eugenia jambolana seed in diabetic rats: study on gastric mucosal defensive factors.
Indian J Physiol Pharmacol. 2009 Jan-Mar; 53(1):16-24.IJ

Abstract

Diabetes has been reported to cause an increase in offensive and decrease in defensive gastric mucosal factors, the imbalance of which can cause ulceration and delay the ulcer healing. Eugenia jambolana has been documented to have both antidiabetic and antiulcer activities. The present study evaluates the effects of ethanolic extract of E. jambolana on gastric ulcer healing and on rat gastric mucosal defensive factors in gastric ulcer with co-occurring diabetes. E. jambolana extract was administered orally in the dose of 200 mg/kg once daily for 10 days. E. jambolana extract increased mucin secretion, mucosal glycoprotein and glutathione levels and decreased the lipid peroxidation in gastric mucosa of diabetic rats. Its treatment also reversed the decrease in life span of gastric mucosal cells as indicated by decreased cell shedding in the gastric juice but found to have no effect on cell proliferation, indicating enhanced defensive status. E. jambolana extract was effective in reversing the delayed healing of gastric ulcer in diabetic rats near to the normal level. E. jambolana showed better ulcer healing effect than glibenclamide, because of its both antihyperglycemic and mucosal defensive actions. It could thus, be a better choice for treating gastric ulcers co-occurring with diabetes.

Authors+Show Affiliations

Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19810572

Citation

Chaturvedi, Aditi, et al. "Ulcer Healing Properties of Ethanolic Extract of Eugenia Jambolana Seed in Diabetic Rats: Study On Gastric Mucosal Defensive Factors." Indian Journal of Physiology and Pharmacology, vol. 53, no. 1, 2009, pp. 16-24.
Chaturvedi A, Bhawani G, Agarwal PK, et al. Ulcer healing properties of ethanolic extract of Eugenia jambolana seed in diabetic rats: study on gastric mucosal defensive factors. Indian J Physiol Pharmacol. 2009;53(1):16-24.
Chaturvedi, A., Bhawani, G., Agarwal, P. K., Goel, S., Singh, A., & Goel, R. K. (2009). Ulcer healing properties of ethanolic extract of Eugenia jambolana seed in diabetic rats: study on gastric mucosal defensive factors. Indian Journal of Physiology and Pharmacology, 53(1), 16-24.
Chaturvedi A, et al. Ulcer Healing Properties of Ethanolic Extract of Eugenia Jambolana Seed in Diabetic Rats: Study On Gastric Mucosal Defensive Factors. Indian J Physiol Pharmacol. 2009 Jan-Mar;53(1):16-24. PubMed PMID: 19810572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ulcer healing properties of ethanolic extract of Eugenia jambolana seed in diabetic rats: study on gastric mucosal defensive factors. AU - Chaturvedi,Aditi, AU - Bhawani,G, AU - Agarwal,P K, AU - Goel,Shalini, AU - Singh,A, AU - Goel,R K, PY - 2009/10/9/entrez PY - 2009/10/9/pubmed PY - 2009/12/16/medline SP - 16 EP - 24 JF - Indian journal of physiology and pharmacology JO - Indian J Physiol Pharmacol VL - 53 IS - 1 N2 - Diabetes has been reported to cause an increase in offensive and decrease in defensive gastric mucosal factors, the imbalance of which can cause ulceration and delay the ulcer healing. Eugenia jambolana has been documented to have both antidiabetic and antiulcer activities. The present study evaluates the effects of ethanolic extract of E. jambolana on gastric ulcer healing and on rat gastric mucosal defensive factors in gastric ulcer with co-occurring diabetes. E. jambolana extract was administered orally in the dose of 200 mg/kg once daily for 10 days. E. jambolana extract increased mucin secretion, mucosal glycoprotein and glutathione levels and decreased the lipid peroxidation in gastric mucosa of diabetic rats. Its treatment also reversed the decrease in life span of gastric mucosal cells as indicated by decreased cell shedding in the gastric juice but found to have no effect on cell proliferation, indicating enhanced defensive status. E. jambolana extract was effective in reversing the delayed healing of gastric ulcer in diabetic rats near to the normal level. E. jambolana showed better ulcer healing effect than glibenclamide, because of its both antihyperglycemic and mucosal defensive actions. It could thus, be a better choice for treating gastric ulcers co-occurring with diabetes. SN - 0019-5499 UR - https://www.unboundmedicine.com/medline/citation/19810572/Ulcer_healing_properties_of_ethanolic_extract_of_Eugenia_jambolana_seed_in_diabetic_rats:_study_on_gastric_mucosal_defensive_factors_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -