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Protective effect of curcumin against kainic acid induced seizures and oxidative stress in rats.
Indian J Physiol Pharmacol. 2009 Jan-Mar; 53(1):39-46.IJ

Abstract

The effect of curcumin, a dietary antioxidant was studied against kainic acid (KA)-induced seizures and on markers of oxidative stress. Rats were administered KA (10 mg/kg, ip) and observed for behavioral changes, incidence and latency of convulsions and mortality over four hours. The rats were thereafter sacrificed for estimation of oxidative stress parameters; malondialdehyde (MDA) and glutathione (GSH). Curcumin was administered 30 min before KA at doses of 50, 100 and 200 mg/kg, ip. KA induced long-lasting seizures and associated symptoms. The brain level of MDA was significantly (P < 0.05) raised after KA administration (536 +/- 44 nmol/g wet tissue) as compared to saline treated group (200 +/- 36 nmol/g wet tissue) and significantly decreased the levels of GSH. Pretreatment with curcumin (100 and 200 mg/kg, ip) significantly increased the latency of seizures (120 + 20 min and 11 5+/- 5.7 min respectively) as compared to the vehicle treated KA group. Curcumin (100 and 200 mg/ kg, ip) significantly prevented the increase in MDA levels and ameliorated the fall in glutathione. Curcumin at the dose of 50 mg/kg had no effect on any of oxidative stress parameters. The study reports the potential antiepileptic effect of antioxidant curcumin.

Authors+Show Affiliations

Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110 029. yk.ykgupta@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19810575

Citation

Gupta, Yogendra K., et al. "Protective Effect of Curcumin Against Kainic Acid Induced Seizures and Oxidative Stress in Rats." Indian Journal of Physiology and Pharmacology, vol. 53, no. 1, 2009, pp. 39-46.
Gupta YK, Briyal S, Sharma M. Protective effect of curcumin against kainic acid induced seizures and oxidative stress in rats. Indian J Physiol Pharmacol. 2009;53(1):39-46.
Gupta, Y. K., Briyal, S., & Sharma, M. (2009). Protective effect of curcumin against kainic acid induced seizures and oxidative stress in rats. Indian Journal of Physiology and Pharmacology, 53(1), 39-46.
Gupta YK, Briyal S, Sharma M. Protective Effect of Curcumin Against Kainic Acid Induced Seizures and Oxidative Stress in Rats. Indian J Physiol Pharmacol. 2009 Jan-Mar;53(1):39-46. PubMed PMID: 19810575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of curcumin against kainic acid induced seizures and oxidative stress in rats. AU - Gupta,Yogendra K, AU - Briyal,Seema, AU - Sharma,Monisha, PY - 2009/10/9/entrez PY - 2009/10/9/pubmed PY - 2009/12/16/medline SP - 39 EP - 46 JF - Indian journal of physiology and pharmacology JO - Indian J Physiol Pharmacol VL - 53 IS - 1 N2 - The effect of curcumin, a dietary antioxidant was studied against kainic acid (KA)-induced seizures and on markers of oxidative stress. Rats were administered KA (10 mg/kg, ip) and observed for behavioral changes, incidence and latency of convulsions and mortality over four hours. The rats were thereafter sacrificed for estimation of oxidative stress parameters; malondialdehyde (MDA) and glutathione (GSH). Curcumin was administered 30 min before KA at doses of 50, 100 and 200 mg/kg, ip. KA induced long-lasting seizures and associated symptoms. The brain level of MDA was significantly (P < 0.05) raised after KA administration (536 +/- 44 nmol/g wet tissue) as compared to saline treated group (200 +/- 36 nmol/g wet tissue) and significantly decreased the levels of GSH. Pretreatment with curcumin (100 and 200 mg/kg, ip) significantly increased the latency of seizures (120 + 20 min and 11 5+/- 5.7 min respectively) as compared to the vehicle treated KA group. Curcumin (100 and 200 mg/ kg, ip) significantly prevented the increase in MDA levels and ameliorated the fall in glutathione. Curcumin at the dose of 50 mg/kg had no effect on any of oxidative stress parameters. The study reports the potential antiepileptic effect of antioxidant curcumin. SN - 0019-5499 UR - https://www.unboundmedicine.com/medline/citation/19810575/Protective_effect_of_curcumin_against_kainic_acid_induced_seizures_and_oxidative_stress_in_rats_ L2 - https://medlineplus.gov/seizures.html DB - PRIME DP - Unbound Medicine ER -