Tags

Type your tag names separated by a space and hit enter

Streptococcus pneumoniae colonization among patients with human immunodeficiency virus-1 who had received 23-valent polysaccharide pneumococcal vaccine.
J Microbiol Immunol Infect. 2009 Jun; 42(3):234-42.JM

Abstract

BACKGROUND AND PURPOSE

To evaluate the impact of 23-valent polysaccharide pneumococcal vaccine on Streptococcus pneumoniae colonization in the upper airway of patients with human immunodeficiency virus (HIV)-1 in Taiwan.

METHODS

302 HIV-infected patients aged 15 years or older underwent swab cultures of the posterior pharynx and tonsils for S. pneumoniae between June 1, 2000 and June 30, 2002. 198 patients (65.6%) had received 23-valent polysaccharide pneumococcal vaccine with a median interval of 420 days (range, 27-634 days) before cultures were performed. Clinical characteristics and laboratory findings were analyzed to determine the factors associated with S. pneumoniae colonization in the upper airway.

RESULTS

Twenty patients (6.6%) had colonization with S. pneumoniae: 15 of 198 patients (7.6%) who had received 23-valent polysaccharide pneumococcal vaccine and 5 of 104 patients (4.8%) who had not received the vaccine (p = 0.37). According to the multivariate analysis, smoking was the only factor that was statistically significantly associated with S. pneumoniae colonization (adjusted odds ratio, 4.03; 95% confidence interval, 1.04-15.64; p = 0.04); pneumococcal vaccination was not statistically significantly associated with S. pneumoniae colonization.

CONCLUSIONS

Among HIV-infected patients, smoking was the only factor significantly associated with a higher prevalence of upper airway colonization by S. pneumoniae. As previous receipt of 23-valent polysaccharide pneumococcal vaccine was not associated with a lower prevalence of S. pneumoniae colonization, a better vaccination strategy, in addition to smoking cessation, may be needed to reduce S. pneumoniae colonization in HIV-infected adults.

Authors+Show Affiliations

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19812857

Citation

Lo, Yi-Chun, et al. "Streptococcus Pneumoniae Colonization Among Patients With Human Immunodeficiency Virus-1 Who Had Received 23-valent Polysaccharide Pneumococcal Vaccine." Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, vol. 42, no. 3, 2009, pp. 234-42.
Lo YC, Lauderdale TL, Chang SY, et al. Streptococcus pneumoniae colonization among patients with human immunodeficiency virus-1 who had received 23-valent polysaccharide pneumococcal vaccine. J Microbiol Immunol Infect. 2009;42(3):234-42.
Lo, Y. C., Lauderdale, T. L., Chang, S. Y., Hsiao, C. F., Hung, C. C., & Chang, S. C. (2009). Streptococcus pneumoniae colonization among patients with human immunodeficiency virus-1 who had received 23-valent polysaccharide pneumococcal vaccine. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 42(3), 234-42.
Lo YC, et al. Streptococcus Pneumoniae Colonization Among Patients With Human Immunodeficiency Virus-1 Who Had Received 23-valent Polysaccharide Pneumococcal Vaccine. J Microbiol Immunol Infect. 2009;42(3):234-42. PubMed PMID: 19812857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Streptococcus pneumoniae colonization among patients with human immunodeficiency virus-1 who had received 23-valent polysaccharide pneumococcal vaccine. AU - Lo,Yi-Chun, AU - Lauderdale,Tsai-Ling, AU - Chang,Sui-Yuan, AU - Hsiao,Chin-Fu, AU - Hung,Chien-Ching, AU - Chang,Shan-Chwen, PY - 2009/10/9/entrez PY - 2009/10/9/pubmed PY - 2010/3/12/medline SP - 234 EP - 42 JF - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JO - J Microbiol Immunol Infect VL - 42 IS - 3 N2 - BACKGROUND AND PURPOSE: To evaluate the impact of 23-valent polysaccharide pneumococcal vaccine on Streptococcus pneumoniae colonization in the upper airway of patients with human immunodeficiency virus (HIV)-1 in Taiwan. METHODS: 302 HIV-infected patients aged 15 years or older underwent swab cultures of the posterior pharynx and tonsils for S. pneumoniae between June 1, 2000 and June 30, 2002. 198 patients (65.6%) had received 23-valent polysaccharide pneumococcal vaccine with a median interval of 420 days (range, 27-634 days) before cultures were performed. Clinical characteristics and laboratory findings were analyzed to determine the factors associated with S. pneumoniae colonization in the upper airway. RESULTS: Twenty patients (6.6%) had colonization with S. pneumoniae: 15 of 198 patients (7.6%) who had received 23-valent polysaccharide pneumococcal vaccine and 5 of 104 patients (4.8%) who had not received the vaccine (p = 0.37). According to the multivariate analysis, smoking was the only factor that was statistically significantly associated with S. pneumoniae colonization (adjusted odds ratio, 4.03; 95% confidence interval, 1.04-15.64; p = 0.04); pneumococcal vaccination was not statistically significantly associated with S. pneumoniae colonization. CONCLUSIONS: Among HIV-infected patients, smoking was the only factor significantly associated with a higher prevalence of upper airway colonization by S. pneumoniae. As previous receipt of 23-valent polysaccharide pneumococcal vaccine was not associated with a lower prevalence of S. pneumoniae colonization, a better vaccination strategy, in addition to smoking cessation, may be needed to reduce S. pneumoniae colonization in HIV-infected adults. SN - 1995-9133 UR - https://www.unboundmedicine.com/medline/citation/19812857/Streptococcus_pneumoniae_colonization_among_patients_with_human_immunodeficiency_virus_1_who_had_received_23_valent_polysaccharide_pneumococcal_vaccine_ L2 - https://medlineplus.gov/pneumococcalinfections.html DB - PRIME DP - Unbound Medicine ER -