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Statins and stroke prevention.
Expert Rev Cardiovasc Ther 2009; 7(10):1231-43ER

Abstract

Over the past decade, statins have been proved to significantly decrease coronary events in the primary and secondary prevention of coronary artery disease. Recent clinical trials have indicated that statins significantly reduce stroke risk in patients with vascular disease. A meta-analysis of randomized trials of statins in combination with other preventive strategies, involving 165,792 individuals, showed that each 1-mmol/l (39 mg/dl) decrease in LDL-cholesterol equates to a reduction in relative risk for stroke of 21.1 (95% CI: 6.3-33.5; p = 0.009). It is not known whether these findings might be due to the cholesterol-reduction effect of statins or to the pleiotropic effects of statins, such as improved endothelial function, decreased platelet aggregability and reduced vascular inflammation. In the secondary prevention of stroke, The Stroke Prevention by Aggressive Reduction of Cholesterol Levels study found that treatment with atorvastatin reduced the risk of recurrent cerebrovascular events in patients with recent stroke or transient ischemic attack but no history of heart disease.

Authors+Show Affiliations

Stroke Unit and Division of Cardiovascular Medicine, Universiy of Perugia, Santa Maria della Misericordia Hospital, Sant'Andrea delle Fratte, 06126 - Perugia, Italy. maurizio.paciaroni@med.unipg.itNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19814666

Citation

Paciaroni, Maurizio, and Julien Bogousslavsky. "Statins and Stroke Prevention." Expert Review of Cardiovascular Therapy, vol. 7, no. 10, 2009, pp. 1231-43.
Paciaroni M, Bogousslavsky J. Statins and stroke prevention. Expert Rev Cardiovasc Ther. 2009;7(10):1231-43.
Paciaroni, M., & Bogousslavsky, J. (2009). Statins and stroke prevention. Expert Review of Cardiovascular Therapy, 7(10), pp. 1231-43. doi:10.1586/erc.09.106.
Paciaroni M, Bogousslavsky J. Statins and Stroke Prevention. Expert Rev Cardiovasc Ther. 2009;7(10):1231-43. PubMed PMID: 19814666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statins and stroke prevention. AU - Paciaroni,Maurizio, AU - Bogousslavsky,Julien, PY - 2009/10/10/entrez PY - 2009/10/10/pubmed PY - 2010/1/13/medline SP - 1231 EP - 43 JF - Expert review of cardiovascular therapy JO - Expert Rev Cardiovasc Ther VL - 7 IS - 10 N2 - Over the past decade, statins have been proved to significantly decrease coronary events in the primary and secondary prevention of coronary artery disease. Recent clinical trials have indicated that statins significantly reduce stroke risk in patients with vascular disease. A meta-analysis of randomized trials of statins in combination with other preventive strategies, involving 165,792 individuals, showed that each 1-mmol/l (39 mg/dl) decrease in LDL-cholesterol equates to a reduction in relative risk for stroke of 21.1 (95% CI: 6.3-33.5; p = 0.009). It is not known whether these findings might be due to the cholesterol-reduction effect of statins or to the pleiotropic effects of statins, such as improved endothelial function, decreased platelet aggregability and reduced vascular inflammation. In the secondary prevention of stroke, The Stroke Prevention by Aggressive Reduction of Cholesterol Levels study found that treatment with atorvastatin reduced the risk of recurrent cerebrovascular events in patients with recent stroke or transient ischemic attack but no history of heart disease. SN - 1744-8344 UR - https://www.unboundmedicine.com/medline/citation/19814666/Statins_and_stroke_prevention_ L2 - http://www.tandfonline.com/doi/full/10.1586/erc.09.106 DB - PRIME DP - Unbound Medicine ER -