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Low-dose aspirin and medical record-confirmed age-related macular degeneration in a randomized trial of women.
Ophthalmology 2009; 116(12):2386-92O

Abstract

OBJECTIVE

To test whether alternate-day low-dose aspirin affects incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women.

DESIGN

Randomized, double-masked, placebo-controlled trial.

PARTICIPANTS

Thirty-nine thousand eight hundred seventy-six healthy female health professionals aged 45 years or older.

INTERVENTION

Participants were assigned randomly to receive either 100 mg aspirin on alternate days or placebo and were followed up for the presence of AMD for an average of 10 years.

MAIN OUTCOME MEASURES

Incident AMD responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-report confirmed by medical record review.

RESULTS

After 10 years of treatment and follow-up, there were 111 cases of AMD in the aspirin group and 134 cases in the placebo group (hazard ratio, 0.82; 95% confidence interval, 0.64-1.06).

CONCLUSIONS

In a large-scale randomized trial of female health professionals with 10 years of treatment and follow-up, low-dose aspirin had no large beneficial or harmful effect on risk of AMD.

Authors+Show Affiliations

Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. wchristen@rics.bwh.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19815293

Citation

Christen, William G., et al. "Low-dose Aspirin and Medical Record-confirmed Age-related Macular Degeneration in a Randomized Trial of Women." Ophthalmology, vol. 116, no. 12, 2009, pp. 2386-92.
Christen WG, Glynn RJ, Chew EY, et al. Low-dose aspirin and medical record-confirmed age-related macular degeneration in a randomized trial of women. Ophthalmology. 2009;116(12):2386-92.
Christen, W. G., Glynn, R. J., Chew, E. Y., & Buring, J. E. (2009). Low-dose aspirin and medical record-confirmed age-related macular degeneration in a randomized trial of women. Ophthalmology, 116(12), pp. 2386-92. doi:10.1016/j.ophtha.2009.05.031.
Christen WG, et al. Low-dose Aspirin and Medical Record-confirmed Age-related Macular Degeneration in a Randomized Trial of Women. Ophthalmology. 2009;116(12):2386-92. PubMed PMID: 19815293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-dose aspirin and medical record-confirmed age-related macular degeneration in a randomized trial of women. AU - Christen,William G, AU - Glynn,Robert J, AU - Chew,Emily Y, AU - Buring,Julie E, Y1 - 2009/10/07/ PY - 2008/12/17/received PY - 2009/05/22/revised PY - 2009/05/22/accepted PY - 2009/10/10/entrez PY - 2009/10/10/pubmed PY - 2009/12/16/medline SP - 2386 EP - 92 JF - Ophthalmology JO - Ophthalmology VL - 116 IS - 12 N2 - OBJECTIVE: To test whether alternate-day low-dose aspirin affects incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women. DESIGN: Randomized, double-masked, placebo-controlled trial. PARTICIPANTS: Thirty-nine thousand eight hundred seventy-six healthy female health professionals aged 45 years or older. INTERVENTION: Participants were assigned randomly to receive either 100 mg aspirin on alternate days or placebo and were followed up for the presence of AMD for an average of 10 years. MAIN OUTCOME MEASURES: Incident AMD responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-report confirmed by medical record review. RESULTS: After 10 years of treatment and follow-up, there were 111 cases of AMD in the aspirin group and 134 cases in the placebo group (hazard ratio, 0.82; 95% confidence interval, 0.64-1.06). CONCLUSIONS: In a large-scale randomized trial of female health professionals with 10 years of treatment and follow-up, low-dose aspirin had no large beneficial or harmful effect on risk of AMD. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/19815293/Low_dose_aspirin_and_medical_record_confirmed_age_related_macular_degeneration_in_a_randomized_trial_of_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(09)00550-8 DB - PRIME DP - Unbound Medicine ER -