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Hepatotoxicity induced by gibberellic acid in adult rats and their progeny.
Exp Toxicol Pathol. 2010 Nov; 62(6):637-42.ET

Abstract

Gibberellic acid (GA(3)), a plant growth regulator, was largely used in agriculture of many countries including Tunisia. However, its potential hazardous effects on human health were relatively unexplored. The purpose of this study was to investigate the effects of GA(3) on hepatic function in female rats and their pups. Animals were given daily 200 ppm GA(3) in drinking water from the 14th day of pregnancy until day 14 after delivery. It was found that GA(3) induced liver damages as evidenced by the elevation of plasma aminotransferases (ALT, AST), lactate dehydrogenase activities, bilirubin and albumin levels. Hepatotoxicity was objectified by the significant increase of malondialdehyde (MDA) level and a decrease of antioxidant enzyme activities such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione content in liver of suckling pups and their mothers. Impairment of hepatic function corresponded histologically. We have observed blood vessels congestion and leucocytes infiltration, which were more pronounced in hepatocytes of dams than those of suckling pups. Results of this current study suggest that exposure rats to GA(3) induces hepatotoxicity and histopathological changes in liver of female rats and their progeny.

Authors+Show Affiliations

Department of Life Sciences, Animal Physiology Laboratory, Sciences Faculty of Sfax, Sfax, Tunisia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19815399

Citation

Troudi, Afef, et al. "Hepatotoxicity Induced By Gibberellic Acid in Adult Rats and Their Progeny." Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, vol. 62, no. 6, 2010, pp. 637-42.
Troudi A, Mahjoubi Samet A, Zeghal N. Hepatotoxicity induced by gibberellic acid in adult rats and their progeny. Exp Toxicol Pathol. 2010;62(6):637-42.
Troudi, A., Mahjoubi Samet, A., & Zeghal, N. (2010). Hepatotoxicity induced by gibberellic acid in adult rats and their progeny. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie, 62(6), 637-42. https://doi.org/10.1016/j.etp.2009.08.010
Troudi A, Mahjoubi Samet A, Zeghal N. Hepatotoxicity Induced By Gibberellic Acid in Adult Rats and Their Progeny. Exp Toxicol Pathol. 2010;62(6):637-42. PubMed PMID: 19815399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatotoxicity induced by gibberellic acid in adult rats and their progeny. AU - Troudi,Afef, AU - Mahjoubi Samet,Amira, AU - Zeghal,Najiba, Y1 - 2009/10/07/ PY - 2009/06/26/received PY - 2009/07/23/revised PY - 2009/08/21/accepted PY - 2009/10/10/entrez PY - 2009/10/10/pubmed PY - 2011/3/5/medline SP - 637 EP - 42 JF - Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie JO - Exp. Toxicol. Pathol. VL - 62 IS - 6 N2 - Gibberellic acid (GA(3)), a plant growth regulator, was largely used in agriculture of many countries including Tunisia. However, its potential hazardous effects on human health were relatively unexplored. The purpose of this study was to investigate the effects of GA(3) on hepatic function in female rats and their pups. Animals were given daily 200 ppm GA(3) in drinking water from the 14th day of pregnancy until day 14 after delivery. It was found that GA(3) induced liver damages as evidenced by the elevation of plasma aminotransferases (ALT, AST), lactate dehydrogenase activities, bilirubin and albumin levels. Hepatotoxicity was objectified by the significant increase of malondialdehyde (MDA) level and a decrease of antioxidant enzyme activities such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione content in liver of suckling pups and their mothers. Impairment of hepatic function corresponded histologically. We have observed blood vessels congestion and leucocytes infiltration, which were more pronounced in hepatocytes of dams than those of suckling pups. Results of this current study suggest that exposure rats to GA(3) induces hepatotoxicity and histopathological changes in liver of female rats and their progeny. SN - 1618-1433 UR - https://www.unboundmedicine.com/medline/citation/19815399/Hepatotoxicity_induced_by_gibberellic_acid_in_adult_rats_and_their_progeny_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0940-2993(09)00237-1 DB - PRIME DP - Unbound Medicine ER -