Tags

Type your tag names separated by a space and hit enter

Morphology and accommodative function of the vitreous zonule in human and monkey eyes.
Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1554-64.IO

Abstract

PURPOSE

To explore the attachments of the posterior zonule and vitreous in relation to accommodation and presbyopia in monkeys and humans.

METHODS

Novel scanning electron microscopy (SEM) and ultrasound biomicroscopy (UBM) techniques were used to visualize the anterior, intermediate, and posterior vitreous zonule and their connections to the ciliary body, vitreous membrane, lens capsule, and ora serrata, and to characterize their age-related changes and correlate them with loss of accommodative forward movement of the ciliary body. alpha-Chymotrypsin was used focally to lyse the vitreous zonule and determine the effect on movement of the accommodative apparatus in monkeys.

RESULTS

The vitreous attached to the peripheral lens capsule and the ora serrata directly. The pars plana zonule and the posterior tines of the anterior zonule were separated from the vitreous membrane except for strategically placed attachments, collectively termed the vitreous zonule, that may modulate and smooth the forward and backward movements of the entire system. Age-dependent changes in these relationships correlated significantly with loss of accommodative amplitude. Lysis of the intermediate vitreous zonule partially restored accommodative movement.

CONCLUSIONS

The vitreous zonule system may help to smoothly translate to the lens the driving forces of accommodation and disaccommodation generated by the ciliary muscle, while maintaining visual focus and protecting the lens capsule and ora serrata from acute tractional forces. Stiffening of the vitreous zonular system may contribute to age-related loss of accommodation and offer a therapeutic target for presbyopia.

Authors+Show Affiliations

Institute of Anatomy II, University of Erlangen-Nuremberg, Erlangen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19815737

Citation

Lütjen-Drecoll, Elke, et al. "Morphology and Accommodative Function of the Vitreous Zonule in Human and Monkey Eyes." Investigative Ophthalmology & Visual Science, vol. 51, no. 3, 2010, pp. 1554-64.
Lütjen-Drecoll E, Kaufman PL, Wasielewski R, et al. Morphology and accommodative function of the vitreous zonule in human and monkey eyes. Invest Ophthalmol Vis Sci. 2010;51(3):1554-64.
Lütjen-Drecoll, E., Kaufman, P. L., Wasielewski, R., Ting-Li, L., & Croft, M. A. (2010). Morphology and accommodative function of the vitreous zonule in human and monkey eyes. Investigative Ophthalmology & Visual Science, 51(3), 1554-64. https://doi.org/10.1167/iovs.09-4008
Lütjen-Drecoll E, et al. Morphology and Accommodative Function of the Vitreous Zonule in Human and Monkey Eyes. Invest Ophthalmol Vis Sci. 2010;51(3):1554-64. PubMed PMID: 19815737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphology and accommodative function of the vitreous zonule in human and monkey eyes. AU - Lütjen-Drecoll,Elke, AU - Kaufman,Paul L, AU - Wasielewski,Rainer, AU - Ting-Li,Lin, AU - Croft,Mary Ann, Y1 - 2009/10/08/ PY - 2009/10/10/entrez PY - 2009/10/10/pubmed PY - 2010/3/27/medline SP - 1554 EP - 64 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 51 IS - 3 N2 - PURPOSE: To explore the attachments of the posterior zonule and vitreous in relation to accommodation and presbyopia in monkeys and humans. METHODS: Novel scanning electron microscopy (SEM) and ultrasound biomicroscopy (UBM) techniques were used to visualize the anterior, intermediate, and posterior vitreous zonule and their connections to the ciliary body, vitreous membrane, lens capsule, and ora serrata, and to characterize their age-related changes and correlate them with loss of accommodative forward movement of the ciliary body. alpha-Chymotrypsin was used focally to lyse the vitreous zonule and determine the effect on movement of the accommodative apparatus in monkeys. RESULTS: The vitreous attached to the peripheral lens capsule and the ora serrata directly. The pars plana zonule and the posterior tines of the anterior zonule were separated from the vitreous membrane except for strategically placed attachments, collectively termed the vitreous zonule, that may modulate and smooth the forward and backward movements of the entire system. Age-dependent changes in these relationships correlated significantly with loss of accommodative amplitude. Lysis of the intermediate vitreous zonule partially restored accommodative movement. CONCLUSIONS: The vitreous zonule system may help to smoothly translate to the lens the driving forces of accommodation and disaccommodation generated by the ciliary muscle, while maintaining visual focus and protecting the lens capsule and ora serrata from acute tractional forces. Stiffening of the vitreous zonular system may contribute to age-related loss of accommodation and offer a therapeutic target for presbyopia. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/19815737/Morphology_and_accommodative_function_of_the_vitreous_zonule_in_human_and_monkey_eyes_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.09-4008 DB - PRIME DP - Unbound Medicine ER -