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'Old' bones in young bodies: the tale of cystic fibrosis.

Abstract

PURPOSE OF REVIEW

Cystic fibrosis (CF) is the most common genetic disease within the white population and leads to premature respiratory failure. Approximately, 60 000 individuals are currently living with CF in North America and Europe, almost half of whom are adults.

RECENT FINDINGS

Dozens of studies across the globe indicate that CF adults have low bone density and increased rates of fractures. This genesis of the problem appears to be in late childhood to adolescence.

SUMMARY

Prevention and treatment of CF-related bone disease must address the myriad risk factors (decreased absorption of fat-soluble vitamins due to pancreatic insufficiency, altered sex hormone production, chronic lung infection with increased serum levels of proinflammatory, bone-active cytokines, malnutrition and low body weight, physical inactivity and glucocorticoid therapy) for poor bone health. This review will address the pathogenesis, diagnosis and treatment of bone disease in CF. It will also discuss best practice guidelines for optimizing bone health in patients with CF.

Authors+Show Affiliations

Division of Pulmonary and Critical Care Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19816169

Citation

Sparks, Amy A., et al. "'Old' Bones in Young Bodies: the Tale of Cystic Fibrosis." Current Opinion in Endocrinology, Diabetes, and Obesity, vol. 16, no. 6, 2009, pp. 407-14.
Sparks AA, McGee SJ, Boone CE, et al. 'Old' bones in young bodies: the tale of cystic fibrosis. Curr Opin Endocrinol Diabetes Obes. 2009;16(6):407-14.
Sparks, A. A., McGee, S. J., Boone, C. E., Neuringer, I. P., Jones, S. K., & Aris, R. M. (2009). 'Old' bones in young bodies: the tale of cystic fibrosis. Current Opinion in Endocrinology, Diabetes, and Obesity, 16(6), pp. 407-14. doi:10.1097/MED.0b013e3283329b16.
Sparks AA, et al. 'Old' Bones in Young Bodies: the Tale of Cystic Fibrosis. Curr Opin Endocrinol Diabetes Obes. 2009;16(6):407-14. PubMed PMID: 19816169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 'Old' bones in young bodies: the tale of cystic fibrosis. AU - Sparks,Amy A, AU - McGee,Sarah J, AU - Boone,Cheryl E, AU - Neuringer,Isabel P, AU - Jones,Sarah K, AU - Aris,Robert M, PY - 2009/10/10/entrez PY - 2009/10/10/pubmed PY - 2010/1/27/medline SP - 407 EP - 14 JF - Current opinion in endocrinology, diabetes, and obesity JO - Curr Opin Endocrinol Diabetes Obes VL - 16 IS - 6 N2 - PURPOSE OF REVIEW: Cystic fibrosis (CF) is the most common genetic disease within the white population and leads to premature respiratory failure. Approximately, 60 000 individuals are currently living with CF in North America and Europe, almost half of whom are adults. RECENT FINDINGS: Dozens of studies across the globe indicate that CF adults have low bone density and increased rates of fractures. This genesis of the problem appears to be in late childhood to adolescence. SUMMARY: Prevention and treatment of CF-related bone disease must address the myriad risk factors (decreased absorption of fat-soluble vitamins due to pancreatic insufficiency, altered sex hormone production, chronic lung infection with increased serum levels of proinflammatory, bone-active cytokines, malnutrition and low body weight, physical inactivity and glucocorticoid therapy) for poor bone health. This review will address the pathogenesis, diagnosis and treatment of bone disease in CF. It will also discuss best practice guidelines for optimizing bone health in patients with CF. SN - 1752-2978 UR - https://www.unboundmedicine.com/medline/citation/19816169/'Old'_bones_in_young_bodies:_the_tale_of_cystic_fibrosis_ L2 - http://Insights.ovid.com/pubmed?pmid=19816169 DB - PRIME DP - Unbound Medicine ER -