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Alcohol drinking and pancreatic cancer risk: a meta-analysis of the dose-risk relation.
Int J Cancer 2010; 126(6):1474-86IJ

Abstract

In order to provide a more precise quantification of the association between alcohol consumption and pancreatic cancer risk, we performed a meta-analysis of relevant dose-risk results. We conducted a PubMed search of all case-control (N=21) and cohort (N=11) studies published up to March 2009. We computed summary relative risk (RR) estimates using either fixed- or, in the presence of heterogeneity, random-effects models. The pooled RR was 0.92 (95% confidence interval, 95% CI, 0.86-0.97) for <3 drinks/day and 1.22 (95% CI, 1.12-1.34) for > or = 3 drinks/day. The increased risk for heavy drinking was similar in women and men, but apparently stronger in cohort studies (RR=1.29), in studies with high quality index (RR=1.30), and did not appear to be explained by residual confounding by either history of pancreatitis or tobacco smoking. This meta-analysis provides strong evidence for the absence of a role of moderate drinking in pancreatic carcinogenesis, coupled to an increased risk for heavy alcohol drinking. Given the moderate increase in risk and the low prevalence of heavy drinkers in most populations, alcohol appears to be responsible only for a small fraction of all pancreatic cancers.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, 20156, Milano, Italy. irene.tramacere@marionegri.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19816941

Citation

Tramacere, Irene, et al. "Alcohol Drinking and Pancreatic Cancer Risk: a Meta-analysis of the Dose-risk Relation." International Journal of Cancer, vol. 126, no. 6, 2010, pp. 1474-86.
Tramacere I, Scotti L, Jenab M, et al. Alcohol drinking and pancreatic cancer risk: a meta-analysis of the dose-risk relation. Int J Cancer. 2010;126(6):1474-86.
Tramacere, I., Scotti, L., Jenab, M., Bagnardi, V., Bellocco, R., Rota, M., ... La Vecchia, C. (2010). Alcohol drinking and pancreatic cancer risk: a meta-analysis of the dose-risk relation. International Journal of Cancer, 126(6), pp. 1474-86. doi:10.1002/ijc.24936.
Tramacere I, et al. Alcohol Drinking and Pancreatic Cancer Risk: a Meta-analysis of the Dose-risk Relation. Int J Cancer. 2010 Mar 15;126(6):1474-86. PubMed PMID: 19816941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol drinking and pancreatic cancer risk: a meta-analysis of the dose-risk relation. AU - Tramacere,Irene, AU - Scotti,Lorenza, AU - Jenab,Mazda, AU - Bagnardi,Vincenzo, AU - Bellocco,Rino, AU - Rota,Matteo, AU - Corrao,Giovanni, AU - Bravi,Francesca, AU - Boffetta,Paolo, AU - La Vecchia,Carlo, PY - 2009/10/10/entrez PY - 2009/10/10/pubmed PY - 2010/2/26/medline SP - 1474 EP - 86 JF - International journal of cancer JO - Int. J. Cancer VL - 126 IS - 6 N2 - In order to provide a more precise quantification of the association between alcohol consumption and pancreatic cancer risk, we performed a meta-analysis of relevant dose-risk results. We conducted a PubMed search of all case-control (N=21) and cohort (N=11) studies published up to March 2009. We computed summary relative risk (RR) estimates using either fixed- or, in the presence of heterogeneity, random-effects models. The pooled RR was 0.92 (95% confidence interval, 95% CI, 0.86-0.97) for <3 drinks/day and 1.22 (95% CI, 1.12-1.34) for > or = 3 drinks/day. The increased risk for heavy drinking was similar in women and men, but apparently stronger in cohort studies (RR=1.29), in studies with high quality index (RR=1.30), and did not appear to be explained by residual confounding by either history of pancreatitis or tobacco smoking. This meta-analysis provides strong evidence for the absence of a role of moderate drinking in pancreatic carcinogenesis, coupled to an increased risk for heavy alcohol drinking. Given the moderate increase in risk and the low prevalence of heavy drinkers in most populations, alcohol appears to be responsible only for a small fraction of all pancreatic cancers. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/19816941/Alcohol_drinking_and_pancreatic_cancer_risk:_a_meta_analysis_of_the_dose_risk_relation_ L2 - https://doi.org/10.1002/ijc.24936 DB - PRIME DP - Unbound Medicine ER -