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Treatment of Barrett's esophagus with high-grade dysplasia and intramucosal adenocarcinoma.
Expert Rev Gastroenterol Hepatol. 2009 Oct; 3(5):493-8.ER

Abstract

High-grade dysplasia and intramucosal adenocarcinoma are premalignant and malignant lesions of the esophagus. The incidence of lymphatic or systemic metastases is low and esophagectomy is curative in most patients. Until recently, complete removal of the neoplastic tissue was reliably accomplished with only esophagectomy. New technologies have been developed that allow endoscopic mucosal resection and ablation with preservation of the esophagus for these lesions. Optimal treatment of the patient requires consideration of not only the stage of the lesion but also the pathophysiology of the esophagus and the severity of the underlying reflux disease. Only with this approach can outcomes be optimized for both the dysplasia or cancer and the patient's reflux disease and long-term quality of life. In this article, we summarize the experience from a surgical center's perspective.

Authors+Show Affiliations

Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo St, Suite 514, Los Angeles, CA 90033, USA. joerg.zehetner@surgery.usc.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19817671

Citation

Zehetner, Jörg, and Steven R. DeMeester. "Treatment of Barrett's Esophagus With High-grade Dysplasia and Intramucosal Adenocarcinoma." Expert Review of Gastroenterology & Hepatology, vol. 3, no. 5, 2009, pp. 493-8.
Zehetner J, DeMeester SR. Treatment of Barrett's esophagus with high-grade dysplasia and intramucosal adenocarcinoma. Expert Rev Gastroenterol Hepatol. 2009;3(5):493-8.
Zehetner, J., & DeMeester, S. R. (2009). Treatment of Barrett's esophagus with high-grade dysplasia and intramucosal adenocarcinoma. Expert Review of Gastroenterology & Hepatology, 3(5), 493-8. https://doi.org/10.1586/egh.09.44
Zehetner J, DeMeester SR. Treatment of Barrett's Esophagus With High-grade Dysplasia and Intramucosal Adenocarcinoma. Expert Rev Gastroenterol Hepatol. 2009;3(5):493-8. PubMed PMID: 19817671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of Barrett's esophagus with high-grade dysplasia and intramucosal adenocarcinoma. AU - Zehetner,Jörg, AU - DeMeester,Steven R, PY - 2009/10/13/entrez PY - 2009/10/13/pubmed PY - 2009/12/18/medline SP - 493 EP - 8 JF - Expert review of gastroenterology & hepatology JO - Expert Rev Gastroenterol Hepatol VL - 3 IS - 5 N2 - High-grade dysplasia and intramucosal adenocarcinoma are premalignant and malignant lesions of the esophagus. The incidence of lymphatic or systemic metastases is low and esophagectomy is curative in most patients. Until recently, complete removal of the neoplastic tissue was reliably accomplished with only esophagectomy. New technologies have been developed that allow endoscopic mucosal resection and ablation with preservation of the esophagus for these lesions. Optimal treatment of the patient requires consideration of not only the stage of the lesion but also the pathophysiology of the esophagus and the severity of the underlying reflux disease. Only with this approach can outcomes be optimized for both the dysplasia or cancer and the patient's reflux disease and long-term quality of life. In this article, we summarize the experience from a surgical center's perspective. SN - 1747-4132 UR - https://www.unboundmedicine.com/medline/citation/19817671/Treatment_of_Barrett's_esophagus_with_high_grade_dysplasia_and_intramucosal_adenocarcinoma_ L2 - http://www.tandfonline.com/doi/full/10.1586/egh.09.44 DB - PRIME DP - Unbound Medicine ER -