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Diabetic macular oedema and visual loss: relationship to location, severity and duration.
Acta Ophthalmol. 2009 Nov; 87(7):709-13.AO

Abstract

PURPOSE

To assess the relationship between visual acuity (VA) and diabetic macular oedema (DMO) in relation to the location of retinal thickening and the severity and duration of central macular thickening.

METHODS

Data from 584 eyes in 340 placebo-treated patients in the 3-years-long Protein Kinase C Diabetic Retinopathy Study (PKC-DRS2) trial were used to investigate the relationship between VA and DMO. Eligible eyes had moderately severe to very severe non-proliferative diabetic retinopathy and VA of at least 45 letters on Early Treatment Diabetic Retinopathy Study (ETDRS) charts (Snellen equivalent = 20/125). Diabetic retinopathy and DMO status were assessed using stereo photographs.

RESULTS

Nearly one third of study eyes had foveal centre-involving DMO at the start of the trial. Sustained moderate visual loss was found in 36 eyes, most commonly associated with DMO at the centre of the fovea in 73% of eyes. There was a strong relationship (p < 0.001) between foveal centre involvement with DMO and mean VA. Mean VA decreased with increasing retinal thickness at the centre (p < 0.001) and increasing duration of centre-involving DMO (p < 0.001).

CONCLUSION

This study documents the relationship between duration of DMO and progressive vision loss, and the key role of central foveal involvement in patients with diabetic retinopathy. These data will help to develop future strategies to prevent vision loss.

Authors+Show Affiliations

Department of Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA. tgardner@psu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase III
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19817721

Citation

Gardner, Thomas W., et al. "Diabetic Macular Oedema and Visual Loss: Relationship to Location, Severity and Duration." Acta Ophthalmologica, vol. 87, no. 7, 2009, pp. 709-13.
Gardner TW, Larsen M, Girach A, et al. Diabetic macular oedema and visual loss: relationship to location, severity and duration. Acta Ophthalmol. 2009;87(7):709-13.
Gardner, T. W., Larsen, M., Girach, A., & Zhi, X. (2009). Diabetic macular oedema and visual loss: relationship to location, severity and duration. Acta Ophthalmologica, 87(7), 709-13. https://doi.org/10.1111/j.1755-3768.2009.01545.x
Gardner TW, et al. Diabetic Macular Oedema and Visual Loss: Relationship to Location, Severity and Duration. Acta Ophthalmol. 2009;87(7):709-13. PubMed PMID: 19817721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetic macular oedema and visual loss: relationship to location, severity and duration. AU - Gardner,Thomas W, AU - Larsen,Michael, AU - Girach,Aniz, AU - Zhi,Xin, AU - ,, Y1 - 2009/10/08/ PY - 2009/10/13/entrez PY - 2009/10/13/pubmed PY - 2010/10/21/medline SP - 709 EP - 13 JF - Acta ophthalmologica JO - Acta Ophthalmol VL - 87 IS - 7 N2 - PURPOSE: To assess the relationship between visual acuity (VA) and diabetic macular oedema (DMO) in relation to the location of retinal thickening and the severity and duration of central macular thickening. METHODS: Data from 584 eyes in 340 placebo-treated patients in the 3-years-long Protein Kinase C Diabetic Retinopathy Study (PKC-DRS2) trial were used to investigate the relationship between VA and DMO. Eligible eyes had moderately severe to very severe non-proliferative diabetic retinopathy and VA of at least 45 letters on Early Treatment Diabetic Retinopathy Study (ETDRS) charts (Snellen equivalent = 20/125). Diabetic retinopathy and DMO status were assessed using stereo photographs. RESULTS: Nearly one third of study eyes had foveal centre-involving DMO at the start of the trial. Sustained moderate visual loss was found in 36 eyes, most commonly associated with DMO at the centre of the fovea in 73% of eyes. There was a strong relationship (p < 0.001) between foveal centre involvement with DMO and mean VA. Mean VA decreased with increasing retinal thickness at the centre (p < 0.001) and increasing duration of centre-involving DMO (p < 0.001). CONCLUSION: This study documents the relationship between duration of DMO and progressive vision loss, and the key role of central foveal involvement in patients with diabetic retinopathy. These data will help to develop future strategies to prevent vision loss. SN - 1755-3768 UR - https://www.unboundmedicine.com/medline/citation/19817721/Diabetic_macular_oedema_and_visual_loss:_relationship_to_location_severity_and_duration_ L2 - https://doi.org/10.1111/j.1755-3768.2009.01545.x DB - PRIME DP - Unbound Medicine ER -