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Melatonin inhibits the development of 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice.
J Pineal Res. 2009 Nov; 47(4):324-9.JP

Abstract

Atopic dermatitis (AD) is a common disease in children, and epicutaneous treatment with a chemical hapten such as 2,4-dinitrofluorobenzene (DNFB) evokes an AD-like reaction in NC/Nga mice under specific pathogen-free conditions. Melatonin (N-acetyl-5-methoxytryptamine) is synthesized by the pineal gland, has several different physiologic functions, which include seasonal reproduction control, immune system modulation, free radical scavenging, and inflammatory suppression. In the present study, we investigated whether melatonin suppresses DNFB-induced AD-like skin lesions in NC/Nga mice. The topical administration of melatonin to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. Furthermore, interleukin (IL)-4 and interferon (IFN)-gamma secretion by activated CD4(+) T cells from the draining lymph nodes of DNFB-treated NC/Nga mice were significantly inhibited by melatonin, and total IgE levels in serum were reduced. Our findings suggest that melatonin suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing total IgE in serum, and IL-4 and IFN-gamma production by activated CD4(+) T cells.

Authors+Show Affiliations

Department of Microbiology (BK21), College of Medicine, Kyung Hee University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19817972

Citation

Kim, Tae-Ho, et al. "Melatonin Inhibits the Development of 2,4-dinitrofluorobenzene-induced Atopic Dermatitis-like Skin Lesions in NC/Nga Mice." Journal of Pineal Research, vol. 47, no. 4, 2009, pp. 324-9.
Kim TH, Jung JA, Kim GD, et al. Melatonin inhibits the development of 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. J Pineal Res. 2009;47(4):324-9.
Kim, T. H., Jung, J. A., Kim, G. D., Jang, A. H., Ahn, H. J., Park, Y. S., & Park, C. S. (2009). Melatonin inhibits the development of 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. Journal of Pineal Research, 47(4), 324-9. https://doi.org/10.1111/j.1600-079X.2009.00718.x
Kim TH, et al. Melatonin Inhibits the Development of 2,4-dinitrofluorobenzene-induced Atopic Dermatitis-like Skin Lesions in NC/Nga Mice. J Pineal Res. 2009;47(4):324-9. PubMed PMID: 19817972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melatonin inhibits the development of 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. AU - Kim,Tae-Ho, AU - Jung,Jung-A, AU - Kim,Gun-Dong, AU - Jang,An-Hee, AU - Ahn,Hyun-Jong, AU - Park,Yong Seek, AU - Park,Cheung-Seog, Y1 - 2009/10/09/ PY - 2009/10/13/entrez PY - 2009/10/13/pubmed PY - 2010/1/9/medline SP - 324 EP - 9 JF - Journal of pineal research JO - J Pineal Res VL - 47 IS - 4 N2 - Atopic dermatitis (AD) is a common disease in children, and epicutaneous treatment with a chemical hapten such as 2,4-dinitrofluorobenzene (DNFB) evokes an AD-like reaction in NC/Nga mice under specific pathogen-free conditions. Melatonin (N-acetyl-5-methoxytryptamine) is synthesized by the pineal gland, has several different physiologic functions, which include seasonal reproduction control, immune system modulation, free radical scavenging, and inflammatory suppression. In the present study, we investigated whether melatonin suppresses DNFB-induced AD-like skin lesions in NC/Nga mice. The topical administration of melatonin to DNFB-treated NC/Nga mice was found to inhibit ear thickness increases and the skin lesions induced by DNFB. Furthermore, interleukin (IL)-4 and interferon (IFN)-gamma secretion by activated CD4(+) T cells from the draining lymph nodes of DNFB-treated NC/Nga mice were significantly inhibited by melatonin, and total IgE levels in serum were reduced. Our findings suggest that melatonin suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing total IgE in serum, and IL-4 and IFN-gamma production by activated CD4(+) T cells. SN - 1600-079X UR - https://www.unboundmedicine.com/medline/citation/19817972/Melatonin_inhibits_the_development_of_24_dinitrofluorobenzene_induced_atopic_dermatitis_like_skin_lesions_in_NC/Nga_mice_ L2 - https://doi.org/10.1111/j.1600-079X.2009.00718.x DB - PRIME DP - Unbound Medicine ER -