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Associations among pain, PTSD, mTBI, and heart rate variability in veterans of Operation Enduring and Iraqi Freedom: a pilot study.
Pain Med. 2009 Oct; 10(7):1237-45.PM

Abstract

OBJECTIVE

The objective of the study was to determine if there is dysregulated autonomic nervous system activity as manifested by depressed heart rate variability (HRV) among veterans of Operations Enduring and Iraqi Freedom (OEF/OIF).

PARTICIPANTS AND SETTING

The study used a convenience sample of OEF/OIF veterans (n = 28) seen at a Level II Polytrauma Network Site at the Michael E. DeBakey VA Medical Center. Participants were similar to other OEF/OIF veterans who received care at this site.

DESIGN

Cross sectional study.

MEASURES

Time domain analysis (standard deviation of beat-to-beat intervals [SDNN]) of HRV, diagnoses of mild traumatic brain injury and post-traumatic stress disorder (PTSD), and pain ratings from medical records.

RESULTS

As a group, the sample evidenced markedly depressed HRV (as reflected by SDNN) as compared with available age and gender corrected normative data. Pain (71%), PTSD (57%), and mild traumatic brain injury (mTBI) (64%) were prevalent. Thirty-six percent had all three measures (P3). Pain and P3 were significantly and negatively associated with SDNN (r = -0.460, P = 0.014; r = -0.373, P = 0.05, respectively).

CONCLUSIONS

These preliminary findings support the high prevalence of depressed HRV and P3 among veterans seen in a level II Polytrauma Center. The findings also suggest a possible synergistic effect of pain, PTSD, and mTBI on depressed HRV. The nature and implications of these relationships require additional research to elucidate.

Authors+Show Affiliations

Michael E DeBakey VA Medical Center, Houston, TX 77030, USA. tan.gabriel@va.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19818034

Citation

Tan, Gabriel, et al. "Associations Among Pain, PTSD, mTBI, and Heart Rate Variability in Veterans of Operation Enduring and Iraqi Freedom: a Pilot Study." Pain Medicine (Malden, Mass.), vol. 10, no. 7, 2009, pp. 1237-45.
Tan G, Fink B, Dao TK, et al. Associations among pain, PTSD, mTBI, and heart rate variability in veterans of Operation Enduring and Iraqi Freedom: a pilot study. Pain Med. 2009;10(7):1237-45.
Tan, G., Fink, B., Dao, T. K., Hebert, R., Farmer, L. S., Sanders, A., Pastorek, N., & Gevirtz, R. (2009). Associations among pain, PTSD, mTBI, and heart rate variability in veterans of Operation Enduring and Iraqi Freedom: a pilot study. Pain Medicine (Malden, Mass.), 10(7), 1237-45. https://doi.org/10.1111/j.1526-4637.2009.00712.x
Tan G, et al. Associations Among Pain, PTSD, mTBI, and Heart Rate Variability in Veterans of Operation Enduring and Iraqi Freedom: a Pilot Study. Pain Med. 2009;10(7):1237-45. PubMed PMID: 19818034.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations among pain, PTSD, mTBI, and heart rate variability in veterans of Operation Enduring and Iraqi Freedom: a pilot study. AU - Tan,Gabriel, AU - Fink,Brandi, AU - Dao,Tam K, AU - Hebert,Russell, AU - Farmer,Lorie S, AU - Sanders,April, AU - Pastorek,Nicholas, AU - Gevirtz,Richard, PY - 2009/10/13/entrez PY - 2009/10/13/pubmed PY - 2010/1/7/medline SP - 1237 EP - 45 JF - Pain medicine (Malden, Mass.) JO - Pain Med VL - 10 IS - 7 N2 - OBJECTIVE: The objective of the study was to determine if there is dysregulated autonomic nervous system activity as manifested by depressed heart rate variability (HRV) among veterans of Operations Enduring and Iraqi Freedom (OEF/OIF). PARTICIPANTS AND SETTING: The study used a convenience sample of OEF/OIF veterans (n = 28) seen at a Level II Polytrauma Network Site at the Michael E. DeBakey VA Medical Center. Participants were similar to other OEF/OIF veterans who received care at this site. DESIGN: Cross sectional study. MEASURES: Time domain analysis (standard deviation of beat-to-beat intervals [SDNN]) of HRV, diagnoses of mild traumatic brain injury and post-traumatic stress disorder (PTSD), and pain ratings from medical records. RESULTS: As a group, the sample evidenced markedly depressed HRV (as reflected by SDNN) as compared with available age and gender corrected normative data. Pain (71%), PTSD (57%), and mild traumatic brain injury (mTBI) (64%) were prevalent. Thirty-six percent had all three measures (P3). Pain and P3 were significantly and negatively associated with SDNN (r = -0.460, P = 0.014; r = -0.373, P = 0.05, respectively). CONCLUSIONS: These preliminary findings support the high prevalence of depressed HRV and P3 among veterans seen in a level II Polytrauma Center. The findings also suggest a possible synergistic effect of pain, PTSD, and mTBI on depressed HRV. The nature and implications of these relationships require additional research to elucidate. SN - 1526-4637 UR - https://www.unboundmedicine.com/medline/citation/19818034/Associations_among_pain_PTSD_mTBI_and_heart_rate_variability_in_veterans_of_Operation_Enduring_and_Iraqi_Freedom:_a_pilot_study_ L2 - https://academic.oup.com/painmedicine/article-lookup/doi/10.1111/j.1526-4637.2009.00712.x DB - PRIME DP - Unbound Medicine ER -