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Higher overcommitment to work is associated with higher plasma cortisol but not ACTH responses in the combined dexamethasone/CRH test in apparently healthy men and women.
Psychoneuroendocrinology 2010; 35(4):536-43P

Abstract

BACKGROUND

Overcommitment (OC) is a pattern of excessive striving that has been associated with alterations in the hypothalamus-pituitary-adrenal (HPA) system. To investigate whether overcommitment is associated with alterations in HPA system function we measured cortisol and adrenocorticotropin (ACTH) release in response to the combined dexamethasone/CRH test.

METHODS

We recruited 92 men and 108 women of a wide range of OC scores including the minimum (6) and maximum (24) of possible OC scores (mean+/-SEM: 13.25+/-.27). We repeatedly measured plasma cortisol and ACTH levels in the combined dexamethasone/CRH test after injection of 100mul CRH preceded by administration of 1.5mg dexamethasone the night before. Moreover, we assessed depressive symptoms (Beck Depression Inventory, BDI) and work stress (effort-reward-imbalance, ERI).

RESULTS

Independent of age and gender, higher OC was associated with higher repeated cortisol (interaction time-by-OC: p=.014, f=.15) but not ACTH (p=.22) secretion in the combined dexamethasone/CRH test. Similarly, higher cortisol (beta=.16, p=.029, R(2)=.02) but not ACTH (p=.47) increase following CRH injection was predicted by higher OC. Depressive symptoms (BDI score) and work stress scores (effort-reward-ratio) did not relate to neuroendocrine responses to the dexamethasone/CRH test. Controlling for depressive symptoms and work stress scores in addition to age and gender did not change results. OC was not associated with ACTH or cortisol pre-test levels.

DISCUSSION

Whereas OC was not associated with alterations in negative feedback sensitivity after dexamethasone administration, our findings indicate that with increasing OC scores, a higher reactivity of the adrenal cortex together with a normal reactivity of the pituitary is observed following subsequent stimulation by CRH injection.

Authors+Show Affiliations

Department of Clinical Psychology and Psychotherapy, University of Zurich, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19818562

Citation

Wirtz, Petra H., et al. "Higher Overcommitment to Work Is Associated With Higher Plasma Cortisol but Not ACTH Responses in the Combined dexamethasone/CRH Test in Apparently Healthy Men and Women." Psychoneuroendocrinology, vol. 35, no. 4, 2010, pp. 536-43.
Wirtz PH, Siegrist J, Schuhmacher A, et al. Higher overcommitment to work is associated with higher plasma cortisol but not ACTH responses in the combined dexamethasone/CRH test in apparently healthy men and women. Psychoneuroendocrinology. 2010;35(4):536-43.
Wirtz, P. H., Siegrist, J., Schuhmacher, A., Hoefels, S., Maier, W., & Zobel, A. W. (2010). Higher overcommitment to work is associated with higher plasma cortisol but not ACTH responses in the combined dexamethasone/CRH test in apparently healthy men and women. Psychoneuroendocrinology, 35(4), pp. 536-43. doi:10.1016/j.psyneuen.2009.09.002.
Wirtz PH, et al. Higher Overcommitment to Work Is Associated With Higher Plasma Cortisol but Not ACTH Responses in the Combined dexamethasone/CRH Test in Apparently Healthy Men and Women. Psychoneuroendocrinology. 2010;35(4):536-43. PubMed PMID: 19818562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher overcommitment to work is associated with higher plasma cortisol but not ACTH responses in the combined dexamethasone/CRH test in apparently healthy men and women. AU - Wirtz,Petra H, AU - Siegrist,Johannes, AU - Schuhmacher,Anna, AU - Hoefels,Susanne, AU - Maier,Wolfgang, AU - Zobel,Astrid W, Y1 - 2009/10/08/ PY - 2009/02/10/received PY - 2009/08/31/revised PY - 2009/09/02/accepted PY - 2009/10/13/entrez PY - 2009/10/13/pubmed PY - 2010/6/18/medline SP - 536 EP - 43 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 35 IS - 4 N2 - BACKGROUND: Overcommitment (OC) is a pattern of excessive striving that has been associated with alterations in the hypothalamus-pituitary-adrenal (HPA) system. To investigate whether overcommitment is associated with alterations in HPA system function we measured cortisol and adrenocorticotropin (ACTH) release in response to the combined dexamethasone/CRH test. METHODS: We recruited 92 men and 108 women of a wide range of OC scores including the minimum (6) and maximum (24) of possible OC scores (mean+/-SEM: 13.25+/-.27). We repeatedly measured plasma cortisol and ACTH levels in the combined dexamethasone/CRH test after injection of 100mul CRH preceded by administration of 1.5mg dexamethasone the night before. Moreover, we assessed depressive symptoms (Beck Depression Inventory, BDI) and work stress (effort-reward-imbalance, ERI). RESULTS: Independent of age and gender, higher OC was associated with higher repeated cortisol (interaction time-by-OC: p=.014, f=.15) but not ACTH (p=.22) secretion in the combined dexamethasone/CRH test. Similarly, higher cortisol (beta=.16, p=.029, R(2)=.02) but not ACTH (p=.47) increase following CRH injection was predicted by higher OC. Depressive symptoms (BDI score) and work stress scores (effort-reward-ratio) did not relate to neuroendocrine responses to the dexamethasone/CRH test. Controlling for depressive symptoms and work stress scores in addition to age and gender did not change results. OC was not associated with ACTH or cortisol pre-test levels. DISCUSSION: Whereas OC was not associated with alterations in negative feedback sensitivity after dexamethasone administration, our findings indicate that with increasing OC scores, a higher reactivity of the adrenal cortex together with a normal reactivity of the pituitary is observed following subsequent stimulation by CRH injection. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/19818562/Higher_overcommitment_to_work_is_associated_with_higher_plasma_cortisol_but_not_ACTH_responses_in_the_combined_dexamethasone/CRH_test_in_apparently_healthy_men_and_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(09)00265-0 DB - PRIME DP - Unbound Medicine ER -