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The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold.
J Pharm Pharmacol 1990; 42(9):652-4JP

Abstract

The effects of oral administration of a lozenge containing 11 mg (-)-menthol on nasal resistance to airflow (NAR) and nasal sensation of airflow in 62 subjects suffering from nasal congestion associated with naturally acquired common cold infection have been studied. NAR was measured by posterior rhinomanometry and nasal sensation of airflow by means of a visual analogue scale (VAS). The effects of the lozenge were compared with a candy placebo lozenge in a double blind randomized trial. NAR showed a significant increase (P less than 0.05) in both the menthol and placebo groups over the 2 h experiment with no difference between the groups at any time. The VAS scores showed significant changes of subjective improvement in nasal sensation of airflow (P less than 0.001) in the menthol-treated group 10 min after dosing whereas the placebo group showed no change. It is concluded that dosing with 11 mg menthol in subjects with common cold has no effect on NAR as measured by posterior rhinomanometry but causes a marked change in nasal sensation of airflow with a subjective sensation of nasal decongestion.

Authors+Show Affiliations

Department of Physiology, University of Wales, Cardiff, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1981905

Citation

Eccles, R, et al. "The Effects of Oral Administration of (-)-menthol On Nasal Resistance to Airflow and Nasal Sensation of Airflow in Subjects Suffering From Nasal Congestion Associated With the Common Cold." The Journal of Pharmacy and Pharmacology, vol. 42, no. 9, 1990, pp. 652-4.
Eccles R, Jawad MS, Morris S. The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold. J Pharm Pharmacol. 1990;42(9):652-4.
Eccles, R., Jawad, M. S., & Morris, S. (1990). The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold. The Journal of Pharmacy and Pharmacology, 42(9), pp. 652-4.
Eccles R, Jawad MS, Morris S. The Effects of Oral Administration of (-)-menthol On Nasal Resistance to Airflow and Nasal Sensation of Airflow in Subjects Suffering From Nasal Congestion Associated With the Common Cold. J Pharm Pharmacol. 1990;42(9):652-4. PubMed PMID: 1981905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold. AU - Eccles,R, AU - Jawad,M S, AU - Morris,S, PY - 1990/9/1/pubmed PY - 1990/9/1/medline PY - 1990/9/1/entrez SP - 652 EP - 4 JF - The Journal of pharmacy and pharmacology JO - J. Pharm. Pharmacol. VL - 42 IS - 9 N2 - The effects of oral administration of a lozenge containing 11 mg (-)-menthol on nasal resistance to airflow (NAR) and nasal sensation of airflow in 62 subjects suffering from nasal congestion associated with naturally acquired common cold infection have been studied. NAR was measured by posterior rhinomanometry and nasal sensation of airflow by means of a visual analogue scale (VAS). The effects of the lozenge were compared with a candy placebo lozenge in a double blind randomized trial. NAR showed a significant increase (P less than 0.05) in both the menthol and placebo groups over the 2 h experiment with no difference between the groups at any time. The VAS scores showed significant changes of subjective improvement in nasal sensation of airflow (P less than 0.001) in the menthol-treated group 10 min after dosing whereas the placebo group showed no change. It is concluded that dosing with 11 mg menthol in subjects with common cold has no effect on NAR as measured by posterior rhinomanometry but causes a marked change in nasal sensation of airflow with a subjective sensation of nasal decongestion. SN - 0022-3573 UR - https://www.unboundmedicine.com/medline/citation/1981905/The_effects_of_oral_administration_of_____menthol_on_nasal_resistance_to_airflow_and_nasal_sensation_of_airflow_in_subjects_suffering_from_nasal_congestion_associated_with_the_common_cold_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0022-3573&date=1990&volume=42&issue=9&spage=652 DB - PRIME DP - Unbound Medicine ER -