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The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold.

Abstract

The effects of oral administration of a lozenge containing 11 mg (-)-menthol on nasal resistance to airflow (NAR) and nasal sensation of airflow in 62 subjects suffering from nasal congestion associated with naturally acquired common cold infection have been studied. NAR was measured by posterior rhinomanometry and nasal sensation of airflow by means of a visual analogue scale (VAS). The effects of the lozenge were compared with a candy placebo lozenge in a double blind randomized trial. NAR showed a significant increase (P less than 0.05) in both the menthol and placebo groups over the 2 h experiment with no difference between the groups at any time. The VAS scores showed significant changes of subjective improvement in nasal sensation of airflow (P less than 0.001) in the menthol-treated group 10 min after dosing whereas the placebo group showed no change. It is concluded that dosing with 11 mg menthol in subjects with common cold has no effect on NAR as measured by posterior rhinomanometry but causes a marked change in nasal sensation of airflow with a subjective sensation of nasal decongestion.

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  • Authors+Show Affiliations

    ,

    Department of Physiology, University of Wales, Cardiff, UK.

    ,

    Source

    MeSH

    Administration, Oral
    Adolescent
    Adult
    Airway Resistance
    Common Cold
    Double-Blind Method
    Female
    Humans
    Male
    Manometry
    Menthol
    Middle Aged
    Nasal Mucosa
    Random Allocation

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    1981905

    Citation

    Eccles, R, et al. "The Effects of Oral Administration of (-)-menthol On Nasal Resistance to Airflow and Nasal Sensation of Airflow in Subjects Suffering From Nasal Congestion Associated With the Common Cold." The Journal of Pharmacy and Pharmacology, vol. 42, no. 9, 1990, pp. 652-4.
    Eccles R, Jawad MS, Morris S. The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold. J Pharm Pharmacol. 1990;42(9):652-4.
    Eccles, R., Jawad, M. S., & Morris, S. (1990). The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold. The Journal of Pharmacy and Pharmacology, 42(9), pp. 652-4.
    Eccles R, Jawad MS, Morris S. The Effects of Oral Administration of (-)-menthol On Nasal Resistance to Airflow and Nasal Sensation of Airflow in Subjects Suffering From Nasal Congestion Associated With the Common Cold. J Pharm Pharmacol. 1990;42(9):652-4. PubMed PMID: 1981905.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold. AU - Eccles,R, AU - Jawad,M S, AU - Morris,S, PY - 1990/9/1/pubmed PY - 1990/9/1/medline PY - 1990/9/1/entrez SP - 652 EP - 4 JF - The Journal of pharmacy and pharmacology JO - J. Pharm. Pharmacol. VL - 42 IS - 9 N2 - The effects of oral administration of a lozenge containing 11 mg (-)-menthol on nasal resistance to airflow (NAR) and nasal sensation of airflow in 62 subjects suffering from nasal congestion associated with naturally acquired common cold infection have been studied. NAR was measured by posterior rhinomanometry and nasal sensation of airflow by means of a visual analogue scale (VAS). The effects of the lozenge were compared with a candy placebo lozenge in a double blind randomized trial. NAR showed a significant increase (P less than 0.05) in both the menthol and placebo groups over the 2 h experiment with no difference between the groups at any time. The VAS scores showed significant changes of subjective improvement in nasal sensation of airflow (P less than 0.001) in the menthol-treated group 10 min after dosing whereas the placebo group showed no change. It is concluded that dosing with 11 mg menthol in subjects with common cold has no effect on NAR as measured by posterior rhinomanometry but causes a marked change in nasal sensation of airflow with a subjective sensation of nasal decongestion. SN - 0022-3573 UR - https://www.unboundmedicine.com/medline/citation/1981905/The_effects_of_oral_administration_of_____menthol_on_nasal_resistance_to_airflow_and_nasal_sensation_of_airflow_in_subjects_suffering_from_nasal_congestion_associated_with_the_common_cold_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0022-3573&date=1990&volume=42&issue=9&spage=652 DB - PRIME DP - Unbound Medicine ER -