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Liquid-liquid-solid microextraction based on membrane-protected molecularly imprinted polymer fiber for trace analysis of triazines in complex aqueous samples.
J Chromatogr A. 2009 Nov 20; 1216(47):8304-11.JC

Abstract

A novel liquid-liquid-solid microextraction (LLSME) technique based on porous membrane-protected molecularly imprinted polymer (MIP)-coated silica fiber has been developed. In this technique, a MIP-coated silica fiber was protected with a length of porous polypropylene hollow fiber membrane which was filled with water-immiscible organic phase. Subsequently the whole device was immersed into aqueous sample for extraction. The LLSME technique was a three-phase microextraction approach. The target analytes were firstly extracted from the aqueous sample through a few microliters of organic phase residing in the pores and lumen of the membrane, and were then finally extracted onto the MIP fiber. A terbutylazine MIP-coated silica fiber was adopted as an example to demonstrate the feasibility of the novel LLSME method. The extraction parameters such as the organic solvent, extraction and desorption time were investigated. Comparison of the LLSME technique was made with molecularly imprinted polymer based solid-phase microextraction (MIP-SPME) and hollow fiber membrane-based liquid-phase microextraction (HF-LPME), respectively. The LLSME, integrating the advantages of high selectivity of MIP-SPME and enrichment and sample cleanup capability of the HF-LPME into a single device, is a promising sample preparation method for complex samples. Moreover, the new technique overcomes the problem of disturbance from water when the MIP-SPME fiber was exposed directly to aqueous samples. Applications to analysis of triazine herbicides in sludge water, watermelon, milk and urine samples were evaluated to access the real sample application of the LLSME method by coupling with high-performance liquid chromatography (HPLC). Low limits of detection (0.006-0.02 microg L(-1)), satisfactory recoveries and good repeatability for real sample (RSD 1.2-9.6%, n = 5) were obtained. The method was demonstrated to be a fast, selective and sensitive pretreatment method for trace analysis of triazines in complex aqueous samples.

Authors+Show Affiliations

School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, China. ceshyl@mail.sysu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19819459

Citation

Hu, Yuling, et al. "Liquid-liquid-solid Microextraction Based On Membrane-protected Molecularly Imprinted Polymer Fiber for Trace Analysis of Triazines in Complex Aqueous Samples." Journal of Chromatography. A, vol. 1216, no. 47, 2009, pp. 8304-11.
Hu Y, Wang Y, Hu Y, et al. Liquid-liquid-solid microextraction based on membrane-protected molecularly imprinted polymer fiber for trace analysis of triazines in complex aqueous samples. J Chromatogr A. 2009;1216(47):8304-11.
Hu, Y., Wang, Y., Hu, Y., & Li, G. (2009). Liquid-liquid-solid microextraction based on membrane-protected molecularly imprinted polymer fiber for trace analysis of triazines in complex aqueous samples. Journal of Chromatography. A, 1216(47), 8304-11. https://doi.org/10.1016/j.chroma.2009.09.063
Hu Y, et al. Liquid-liquid-solid Microextraction Based On Membrane-protected Molecularly Imprinted Polymer Fiber for Trace Analysis of Triazines in Complex Aqueous Samples. J Chromatogr A. 2009 Nov 20;1216(47):8304-11. PubMed PMID: 19819459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liquid-liquid-solid microextraction based on membrane-protected molecularly imprinted polymer fiber for trace analysis of triazines in complex aqueous samples. AU - Hu,Yuling, AU - Wang,Yangyang, AU - Hu,Yufei, AU - Li,Gongke, Y1 - 2009/09/30/ PY - 2009/05/25/received PY - 2009/09/21/revised PY - 2009/09/25/accepted PY - 2009/10/13/entrez PY - 2009/10/13/pubmed PY - 2010/2/19/medline SP - 8304 EP - 11 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1216 IS - 47 N2 - A novel liquid-liquid-solid microextraction (LLSME) technique based on porous membrane-protected molecularly imprinted polymer (MIP)-coated silica fiber has been developed. In this technique, a MIP-coated silica fiber was protected with a length of porous polypropylene hollow fiber membrane which was filled with water-immiscible organic phase. Subsequently the whole device was immersed into aqueous sample for extraction. The LLSME technique was a three-phase microextraction approach. The target analytes were firstly extracted from the aqueous sample through a few microliters of organic phase residing in the pores and lumen of the membrane, and were then finally extracted onto the MIP fiber. A terbutylazine MIP-coated silica fiber was adopted as an example to demonstrate the feasibility of the novel LLSME method. The extraction parameters such as the organic solvent, extraction and desorption time were investigated. Comparison of the LLSME technique was made with molecularly imprinted polymer based solid-phase microextraction (MIP-SPME) and hollow fiber membrane-based liquid-phase microextraction (HF-LPME), respectively. The LLSME, integrating the advantages of high selectivity of MIP-SPME and enrichment and sample cleanup capability of the HF-LPME into a single device, is a promising sample preparation method for complex samples. Moreover, the new technique overcomes the problem of disturbance from water when the MIP-SPME fiber was exposed directly to aqueous samples. Applications to analysis of triazine herbicides in sludge water, watermelon, milk and urine samples were evaluated to access the real sample application of the LLSME method by coupling with high-performance liquid chromatography (HPLC). Low limits of detection (0.006-0.02 microg L(-1)), satisfactory recoveries and good repeatability for real sample (RSD 1.2-9.6%, n = 5) were obtained. The method was demonstrated to be a fast, selective and sensitive pretreatment method for trace analysis of triazines in complex aqueous samples. SN - 1873-3778 UR - https://www.unboundmedicine.com/medline/citation/19819459/Liquid_liquid_solid_microextraction_based_on_membrane_protected_molecularly_imprinted_polymer_fiber_for_trace_analysis_of_triazines_in_complex_aqueous_samples_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(09)01450-2 DB - PRIME DP - Unbound Medicine ER -