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Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan.
J Neurol Sci. 2010 Jan 15; 288(1-2):117-22.JN

Abstract

The present case-control study examined the relationship between dietary intake of individual fatty acids and the risk of Parkinson's disease (PD) in Japan. Included were 249 cases within 6 years of onset of PD. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Compared with arachidonic acid intake in the first quartile, consumption of that in the fourth quartile was significantly related to an increased risk of PD: the adjusted odds ratio between extreme quartiles was 2.09 (95% confidence interval: 1.21-3.64, P for trend=0.008). Cholesterol intake was also significantly positively associated with the risk of PD: the adjusted odds ratio between extreme quartiles was 1.78 (95% confidence interval: 1.04-3.05, P for trend=0.01). Consumption of total fat, saturated fatty acids, monounsaturated fatty acids, n-3 polyunsaturated fatty acids, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, n-6 polyunsaturated fatty acids, and linoleic acid and the ratio of n-3 to n-6 polyunsaturated fatty acid intake were not associated with PD. Higher consumption of arachidonic acid and cholesterol may be related to an increased risk of PD.

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Authors+Show Affiliations

Miyake Y
Department of Public Health, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. miyake-y@fukuoka-u.ac.jp
Sasaki S
No affiliation info available
Tanaka K
No affiliation info available
Fukushima W
No affiliation info available
Kiyohara C
No affiliation info available
Tsuboi Y
No affiliation info available
Yamada T
No affiliation info available
Oeda T
No affiliation info available
Miki T
No affiliation info available
Kawamura N
No affiliation info available
Sakae N
No affiliation info available
Fukuyama H
No affiliation info available
Hirota Y
No affiliation info available
Nagai M
No affiliation info available
Fukuoka Kinki Parkinson's Disease Study Group
No affiliation info available

MeSH

AgedCase-Control StudiesCholesterol, DietaryDiet SurveysDietary FatsFatty AcidsFatty Acids, Omega-3Feeding BehaviorFemaleHumansJapanLogistic ModelsMaleMiddle AgedOdds RatioParkinson DiseaseSocioeconomic FactorsSurveys and Questionnaires

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19819467

Citation

Miyake, Yoshihiro, et al. "Dietary Fat Intake and Risk of Parkinson's Disease: a Case-control Study in Japan." Journal of the Neurological Sciences, vol. 288, no. 1-2, 2010, pp. 117-22.
Miyake Y, Sasaki S, Tanaka K, et al. Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan. J Neurol Sci. 2010;288(1-2):117-22.
Miyake, Y., Sasaki, S., Tanaka, K., Fukushima, W., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y., & Nagai, M. (2010). Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan. Journal of the Neurological Sciences, 288(1-2), 117-22. https://doi.org/10.1016/j.jns.2009.09.021
Miyake Y, et al. Dietary Fat Intake and Risk of Parkinson's Disease: a Case-control Study in Japan. J Neurol Sci. 2010 Jan 15;288(1-2):117-22. PubMed PMID: 19819467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan. AU - Miyake,Yoshihiro, AU - Sasaki,Satoshi, AU - Tanaka,Keiko, AU - Fukushima,Wakaba, AU - Kiyohara,Chikako, AU - Tsuboi,Yoshio, AU - Yamada,Tatsuo, AU - Oeda,Tomoko, AU - Miki,Takami, AU - Kawamura,Nobutoshi, AU - Sakae,Nobutaka, AU - Fukuyama,Hidenao, AU - Hirota,Yoshio, AU - Nagai,Masaki, AU - ,, Y1 - 2009/10/12/ PY - 2009/06/27/received PY - 2009/08/31/revised PY - 2009/09/22/accepted PY - 2009/10/13/entrez PY - 2009/10/13/pubmed PY - 2010/2/18/medline SP - 117 EP - 22 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 288 IS - 1-2 N2 - The present case-control study examined the relationship between dietary intake of individual fatty acids and the risk of Parkinson's disease (PD) in Japan. Included were 249 cases within 6 years of onset of PD. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Compared with arachidonic acid intake in the first quartile, consumption of that in the fourth quartile was significantly related to an increased risk of PD: the adjusted odds ratio between extreme quartiles was 2.09 (95% confidence interval: 1.21-3.64, P for trend=0.008). Cholesterol intake was also significantly positively associated with the risk of PD: the adjusted odds ratio between extreme quartiles was 1.78 (95% confidence interval: 1.04-3.05, P for trend=0.01). Consumption of total fat, saturated fatty acids, monounsaturated fatty acids, n-3 polyunsaturated fatty acids, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, n-6 polyunsaturated fatty acids, and linoleic acid and the ratio of n-3 to n-6 polyunsaturated fatty acid intake were not associated with PD. Higher consumption of arachidonic acid and cholesterol may be related to an increased risk of PD. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/19819467/Dietary_fat_intake_and_risk_of_Parkinson's_disease:_a_case_control_study_in_Japan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(09)00864-8 DB - PRIME DP - Unbound Medicine ER -