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Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan.
J Neurol Sci. 2010 Jan 15; 288(1-2):117-22.JN

Abstract

The present case-control study examined the relationship between dietary intake of individual fatty acids and the risk of Parkinson's disease (PD) in Japan. Included were 249 cases within 6 years of onset of PD. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Compared with arachidonic acid intake in the first quartile, consumption of that in the fourth quartile was significantly related to an increased risk of PD: the adjusted odds ratio between extreme quartiles was 2.09 (95% confidence interval: 1.21-3.64, P for trend=0.008). Cholesterol intake was also significantly positively associated with the risk of PD: the adjusted odds ratio between extreme quartiles was 1.78 (95% confidence interval: 1.04-3.05, P for trend=0.01). Consumption of total fat, saturated fatty acids, monounsaturated fatty acids, n-3 polyunsaturated fatty acids, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, n-6 polyunsaturated fatty acids, and linoleic acid and the ratio of n-3 to n-6 polyunsaturated fatty acid intake were not associated with PD. Higher consumption of arachidonic acid and cholesterol may be related to an increased risk of PD.

Authors+Show Affiliations

Department of Public Health, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. miyake-y@fukuoka-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19819467

Citation

Miyake, Yoshihiro, et al. "Dietary Fat Intake and Risk of Parkinson's Disease: a Case-control Study in Japan." Journal of the Neurological Sciences, vol. 288, no. 1-2, 2010, pp. 117-22.
Miyake Y, Sasaki S, Tanaka K, et al. Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan. J Neurol Sci. 2010;288(1-2):117-22.
Miyake, Y., Sasaki, S., Tanaka, K., Fukushima, W., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y., & Nagai, M. (2010). Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan. Journal of the Neurological Sciences, 288(1-2), 117-22. https://doi.org/10.1016/j.jns.2009.09.021
Miyake Y, et al. Dietary Fat Intake and Risk of Parkinson's Disease: a Case-control Study in Japan. J Neurol Sci. 2010 Jan 15;288(1-2):117-22. PubMed PMID: 19819467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan. AU - Miyake,Yoshihiro, AU - Sasaki,Satoshi, AU - Tanaka,Keiko, AU - Fukushima,Wakaba, AU - Kiyohara,Chikako, AU - Tsuboi,Yoshio, AU - Yamada,Tatsuo, AU - Oeda,Tomoko, AU - Miki,Takami, AU - Kawamura,Nobutoshi, AU - Sakae,Nobutaka, AU - Fukuyama,Hidenao, AU - Hirota,Yoshio, AU - Nagai,Masaki, AU - ,, Y1 - 2009/10/12/ PY - 2009/06/27/received PY - 2009/08/31/revised PY - 2009/09/22/accepted PY - 2009/10/13/entrez PY - 2009/10/13/pubmed PY - 2010/2/18/medline SP - 117 EP - 22 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 288 IS - 1-2 N2 - The present case-control study examined the relationship between dietary intake of individual fatty acids and the risk of Parkinson's disease (PD) in Japan. Included were 249 cases within 6 years of onset of PD. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Compared with arachidonic acid intake in the first quartile, consumption of that in the fourth quartile was significantly related to an increased risk of PD: the adjusted odds ratio between extreme quartiles was 2.09 (95% confidence interval: 1.21-3.64, P for trend=0.008). Cholesterol intake was also significantly positively associated with the risk of PD: the adjusted odds ratio between extreme quartiles was 1.78 (95% confidence interval: 1.04-3.05, P for trend=0.01). Consumption of total fat, saturated fatty acids, monounsaturated fatty acids, n-3 polyunsaturated fatty acids, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, n-6 polyunsaturated fatty acids, and linoleic acid and the ratio of n-3 to n-6 polyunsaturated fatty acid intake were not associated with PD. Higher consumption of arachidonic acid and cholesterol may be related to an increased risk of PD. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/19819467/Dietary_fat_intake_and_risk_of_Parkinson's_disease:_a_case_control_study_in_Japan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(09)00864-8 DB - PRIME DP - Unbound Medicine ER -