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HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children.
Dig Liver Dis. 2010 Jun; 42(6):425-7.DL

Abstract

BACKGROUND

Few data are available on the prevalence of celiac disease (CD)-predisposing, HLA-related genes in Arab populations.

AIM OF THE STUDY

To investigate the distribution of HLA-DQ2 and -DQ8 genotypes in Libyan children with CD and healthy controls.

PATIENTS

We tested 31 Libyan children with CD (22 females and 9 males, median age 9.2 years) and 156 Libyan controls (81 females and 75 males, median age 10.9).

METHODS

HLA genes were determined on a drop of dried blood by the DQ-CD Typing Plus kit (DiaGene, Palermo, Italy).

RESULTS

The HLA-DQ pattern of the 31 CD children was: hetero DQ2 (n=15), DQ2 with homo beta2 (10), DQ8 and beta2 positive (3), DQ8 (2), and hetero beta2 (1). The HLA-DQ pattern of the 156 controls was: hetero DQ2 (n=36), hetero beta2 (30), DQ2-DQ8 negative (23), DQ8 (19), alpha5 (14), DQ2 with homo beta (12), homo beta2 (10), DQ8 and beta2 positive (7), and DQ2/DQ8 (5).

CONCLUSIONS

HLA-DQ2 and -DQ8 in CD patients are as common in Libya as in Italy, but the frequency of "high-risk" genotypes is higher in Libyan than Italian patients. The prevalence of HLA-DQ2 and -DQ8 genes in the Libyan general population is higher than in Italy, indicating a strong genetic predisposition to CD.

Authors+Show Affiliations

Department of Pediatrics, Omar Al Mukhtar University, Al Bayda, Libya.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19819768

Citation

Alarida, Kamla, et al. "HLA-DQ2 and -DQ8 Genotypes in Celiac and Healthy Libyan Children." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 42, no. 6, 2010, pp. 425-7.
Alarida K, Harown J, Di Pierro MR, et al. HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children. Dig Liver Dis. 2010;42(6):425-7.
Alarida, K., Harown, J., Di Pierro, M. R., Drago, S., & Catassi, C. (2010). HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 42(6), 425-7. https://doi.org/10.1016/j.dld.2009.09.004
Alarida K, et al. HLA-DQ2 and -DQ8 Genotypes in Celiac and Healthy Libyan Children. Dig Liver Dis. 2010;42(6):425-7. PubMed PMID: 19819768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children. AU - Alarida,Kamla, AU - Harown,Jumma, AU - Di Pierro,Maria Rosaria, AU - Drago,Sandro, AU - Catassi,Carlo, Y1 - 2009/10/12/ PY - 2009/05/04/received PY - 2009/09/08/revised PY - 2009/09/11/accepted PY - 2009/10/13/entrez PY - 2009/10/13/pubmed PY - 2010/10/13/medline SP - 425 EP - 7 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 42 IS - 6 N2 - BACKGROUND: Few data are available on the prevalence of celiac disease (CD)-predisposing, HLA-related genes in Arab populations. AIM OF THE STUDY: To investigate the distribution of HLA-DQ2 and -DQ8 genotypes in Libyan children with CD and healthy controls. PATIENTS: We tested 31 Libyan children with CD (22 females and 9 males, median age 9.2 years) and 156 Libyan controls (81 females and 75 males, median age 10.9). METHODS: HLA genes were determined on a drop of dried blood by the DQ-CD Typing Plus kit (DiaGene, Palermo, Italy). RESULTS: The HLA-DQ pattern of the 31 CD children was: hetero DQ2 (n=15), DQ2 with homo beta2 (10), DQ8 and beta2 positive (3), DQ8 (2), and hetero beta2 (1). The HLA-DQ pattern of the 156 controls was: hetero DQ2 (n=36), hetero beta2 (30), DQ2-DQ8 negative (23), DQ8 (19), alpha5 (14), DQ2 with homo beta (12), homo beta2 (10), DQ8 and beta2 positive (7), and DQ2/DQ8 (5). CONCLUSIONS: HLA-DQ2 and -DQ8 in CD patients are as common in Libya as in Italy, but the frequency of "high-risk" genotypes is higher in Libyan than Italian patients. The prevalence of HLA-DQ2 and -DQ8 genes in the Libyan general population is higher than in Italy, indicating a strong genetic predisposition to CD. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/19819768/HLA_DQ2_and__DQ8_genotypes_in_celiac_and_healthy_Libyan_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(09)00372-7 DB - PRIME DP - Unbound Medicine ER -