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Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations.
Acta Pharm. 2009 Sep; 59(3):313-23.AP

Abstract

The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and in vitro drug release of the tablets were studied. Applying an exponential equation, it was found that the kinetics of soluble drug release followed anomalous non-Fickian diffusion transport whereas insoluble drug showed zero-order release. SEM study showed pore formation on the tablet surface that differed depending on drug solubility. t-Test pointed to a significant difference in amount of both drugs released due to the difference in solubility. Solubility of the drug effects kinetics and the mechanism of drug release.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Chakraborty S
P.G. Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India. santanu_nil@rediffmail.com
Khandai M
No affiliation info available
Sharma A
No affiliation info available
Patra ChN
No affiliation info available
Patro VJ
No affiliation info available
Sen KK
No affiliation info available

MeSH

Chemistry, PharmaceuticalDelayed-Action PreparationsDiclofenacHypromellose DerivativesMethylcelluloseSolubilityTabletsVerapamilWater

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19819827

Citation

Chakraborty, Santanu, et al. "Effects of Drug Solubility On the Release Kinetics of Water Soluble and Insoluble Drugs From HPMC Based Matrix Formulations." Acta Pharmaceutica (Zagreb, Croatia), vol. 59, no. 3, 2009, pp. 313-23.
Chakraborty S, Khandai M, Sharma A, et al. Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations. Acta Pharm. 2009;59(3):313-23.
Chakraborty, S., Khandai, M., Sharma, A., Patra, C. h. N., Patro, V. J., & Sen, K. K. (2009). Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations. Acta Pharmaceutica (Zagreb, Croatia), 59(3), 313-23. https://doi.org/10.2478/v10007-009-0025-8
Chakraborty S, et al. Effects of Drug Solubility On the Release Kinetics of Water Soluble and Insoluble Drugs From HPMC Based Matrix Formulations. Acta Pharm. 2009;59(3):313-23. PubMed PMID: 19819827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations. AU - Chakraborty,Santanu, AU - Khandai,Madhusmruti, AU - Sharma,Anuradha, AU - Patra,Ch Niranjan, AU - Patro,V Jagannath, AU - Sen,Kalyan Kumar, PY - 2009/10/13/entrez PY - 2009/10/13/pubmed PY - 2010/6/9/medline SP - 313 EP - 23 JF - Acta pharmaceutica (Zagreb, Croatia) JO - Acta Pharm VL - 59 IS - 3 N2 - The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and in vitro drug release of the tablets were studied. Applying an exponential equation, it was found that the kinetics of soluble drug release followed anomalous non-Fickian diffusion transport whereas insoluble drug showed zero-order release. SEM study showed pore formation on the tablet surface that differed depending on drug solubility. t-Test pointed to a significant difference in amount of both drugs released due to the difference in solubility. Solubility of the drug effects kinetics and the mechanism of drug release. SN - 1846-9558 UR - https://www.unboundmedicine.com/medline/citation/19819827/Effects_of_drug_solubility_on_the_release_kinetics_of_water_soluble_and_insoluble_drugs_from_HPMC_based_matrix_formulations_ DB - PRIME DP - Unbound Medicine ER -