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Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC).
Occup Environ Med. 2010 May; 67(5):293-300.OE

Abstract

OBJECTIVES

To investigate the effect of ambient particulate matter on variation in childhood prevalence of asthma, rhinoconjunctivitis and eczema.

METHODS

Prevalences of asthma, rhinoconjunctivitis and eczema obtained in Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC) were matched with city-level estimates of residential PM(10) obtained from a World Bank model. Associations were investigated using binomial regression adjusting for GNP per capita and for clustering within country. For countries with more than one centre, a two stage meta-analysis was carried out. The results were compared with a meta-analysis of published multi-centre studies.

RESULTS

Annual concentrations of PM(10) at city level were obtained for 105 ISAAC centres in 51 countries. After controlling for GNP per capita, there was a weak negative association between PM(10) and various outcomes. For severe wheeze in 13-14-year-olds, the OR for a 10 microg/m(3) increase in PM(10) was 0.92 (95% CI 0.84 to 1.00). In 24 countries with more than one centre, most summary estimates for within-country associations were weakly positive. For severe wheeze in 13-14-year-olds, the summary OR for a 10 microg/m(3) increase in PM(10) was 1.01 (0.92 to 1.10). This result was close to a summary OR of 0.99 (0.91 to 1.06) obtained from published multi-centre studies.

CONCLUSIONS

Modelled estimates of particulate matter at city level are imprecise and incomplete estimates of personal exposure to ambient air pollutants. Nevertheless, our results together with those of previous multi-centre studies, suggest that urban background PM(10) has little or no association with the prevalence of childhood asthma, rhinoconjunctivitis or eczema either within or between countries.

Authors+Show Affiliations

Division of Community Health Sciences, MRC-HPA Centre for Environment and Health, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK. r.anderson@sgul.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase I
Journal Article
Meta-Analysis
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19819866

Citation

Anderson, H Ross, et al. "Ambient Particulate Pollution and the World-wide Prevalence of Asthma, Rhinoconjunctivitis and Eczema in Children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC)." Occupational and Environmental Medicine, vol. 67, no. 5, 2010, pp. 293-300.
Anderson HR, Ruggles R, Pandey KD, et al. Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC). Occup Environ Med. 2010;67(5):293-300.
Anderson, H. R., Ruggles, R., Pandey, K. D., Kapetanakis, V., Brunekreef, B., Lai, C. K., Strachan, D. P., & Weiland, S. K. (2010). Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC). Occupational and Environmental Medicine, 67(5), 293-300. https://doi.org/10.1136/oem.2009.048785
Anderson HR, et al. Ambient Particulate Pollution and the World-wide Prevalence of Asthma, Rhinoconjunctivitis and Eczema in Children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC). Occup Environ Med. 2010;67(5):293-300. PubMed PMID: 19819866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC). AU - Anderson,H Ross, AU - Ruggles,Ruth, AU - Pandey,Kiran D, AU - Kapetanakis,Venediktos, AU - Brunekreef,Bert, AU - Lai,Christopher K W, AU - Strachan,David P, AU - Weiland,Stephan K, AU - ,, Y1 - 2009/10/09/ PY - 2009/10/13/entrez PY - 2009/10/13/pubmed PY - 2010/9/14/medline SP - 293 EP - 300 JF - Occupational and environmental medicine JO - Occup Environ Med VL - 67 IS - 5 N2 - OBJECTIVES: To investigate the effect of ambient particulate matter on variation in childhood prevalence of asthma, rhinoconjunctivitis and eczema. METHODS: Prevalences of asthma, rhinoconjunctivitis and eczema obtained in Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC) were matched with city-level estimates of residential PM(10) obtained from a World Bank model. Associations were investigated using binomial regression adjusting for GNP per capita and for clustering within country. For countries with more than one centre, a two stage meta-analysis was carried out. The results were compared with a meta-analysis of published multi-centre studies. RESULTS: Annual concentrations of PM(10) at city level were obtained for 105 ISAAC centres in 51 countries. After controlling for GNP per capita, there was a weak negative association between PM(10) and various outcomes. For severe wheeze in 13-14-year-olds, the OR for a 10 microg/m(3) increase in PM(10) was 0.92 (95% CI 0.84 to 1.00). In 24 countries with more than one centre, most summary estimates for within-country associations were weakly positive. For severe wheeze in 13-14-year-olds, the summary OR for a 10 microg/m(3) increase in PM(10) was 1.01 (0.92 to 1.10). This result was close to a summary OR of 0.99 (0.91 to 1.06) obtained from published multi-centre studies. CONCLUSIONS: Modelled estimates of particulate matter at city level are imprecise and incomplete estimates of personal exposure to ambient air pollutants. Nevertheless, our results together with those of previous multi-centre studies, suggest that urban background PM(10) has little or no association with the prevalence of childhood asthma, rhinoconjunctivitis or eczema either within or between countries. SN - 1470-7926 UR - https://www.unboundmedicine.com/medline/citation/19819866/Ambient_particulate_pollution_and_the_world_wide_prevalence_of_asthma_rhinoconjunctivitis_and_eczema_in_children:_Phase_One_of_the_International_Study_of_Asthma_and_Allergies_in_Childhood__ISAAC__ L2 - https://oem.bmj.com/lookup/pmidlookup?view=long&pmid=19819866 DB - PRIME DP - Unbound Medicine ER -