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Safety and efficiency of influenza vaccination in systemic lupus erythematosus patients.
Acta Reumatol Port. 2009 Jul-Sep; 34(3):498-502.AR

Abstract

INTRODUCTION

Systemic lupus erythematosus (SLE) patients have a higher infection rate than the general population. The role of influenza vaccination in SLE patients has been a matter of discussion due to the risk of disease exacerbation and to the influence of the disease and its treatment on vaccine efficacy.

OBJECTIVE

To study safety and efficiency of influenza vaccination in SLE patients.

METHODS

We studied 47 SLE patients and 27 healthy controls for influenza hemagglutinin titers before and 6 weeks after immunization. SLE patients were scored for disease activity by SLEDAI before and after receiving the vaccine. We also studied antibody titers in SLE patients according to the use of glucocorticoid, methotrexate and azathioprine.

RESULTS

Seroprotection after vaccination was equal in SLE patients and healthy controls although seroconvertion was lower in SLE patients for one of the three antigens tested. No significant increase in SLEDAI was observed. Medications such as methotrexate and azathioprine did not change the mean titers of antibody response but glucocorticoids did affect the response to one of the antigens.

CONCLUSIONS

Although immune response to influenza vaccine in SLE patients may be diminished it is safe and effective.

Links

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Authors+Show Affiliations

Wallin L
Rheumatology Unit, Hospital Universitário Evangélico de Curitiba, Brazil.
Quintilio W
No affiliation info available
Locatelli F
No affiliation info available
Cassel A
No affiliation info available
Silva MB
No affiliation info available
Skare TL
No affiliation info available

MeSH

AdultAntibodies, ViralFemaleHumansInfluenza VaccinesInfluenza, HumanLupus Erythematosus, SystemicMaleMiddle AgedOrthomyxoviridaeYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19820674

Citation

Wallin, Liz, et al. "Safety and Efficiency of Influenza Vaccination in Systemic Lupus Erythematosus Patients." Acta Reumatologica Portuguesa, vol. 34, no. 3, 2009, pp. 498-502.
Wallin L, Quintilio W, Locatelli F, et al. Safety and efficiency of influenza vaccination in systemic lupus erythematosus patients. Acta Reumatol Port. 2009;34(3):498-502.
Wallin, L., Quintilio, W., Locatelli, F., Cassel, A., Silva, M. B., & Skare, T. L. (2009). Safety and efficiency of influenza vaccination in systemic lupus erythematosus patients. Acta Reumatologica Portuguesa, 34(3), 498-502.
Wallin L, et al. Safety and Efficiency of Influenza Vaccination in Systemic Lupus Erythematosus Patients. Acta Reumatol Port. 2009 Jul-Sep;34(3):498-502. PubMed PMID: 19820674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety and efficiency of influenza vaccination in systemic lupus erythematosus patients. AU - Wallin,Liz, AU - Quintilio,Wagner, AU - Locatelli,Felipe, AU - Cassel,Albino, AU - Silva,Marilia Barreto, AU - Skare,Thelma L, PY - 2009/10/13/entrez PY - 2009/10/13/pubmed PY - 2009/12/24/medline SP - 498 EP - 502 JF - Acta reumatologica portuguesa JO - Acta Reumatol Port VL - 34 IS - 3 N2 - INTRODUCTION: Systemic lupus erythematosus (SLE) patients have a higher infection rate than the general population. The role of influenza vaccination in SLE patients has been a matter of discussion due to the risk of disease exacerbation and to the influence of the disease and its treatment on vaccine efficacy. OBJECTIVE: To study safety and efficiency of influenza vaccination in SLE patients. METHODS: We studied 47 SLE patients and 27 healthy controls for influenza hemagglutinin titers before and 6 weeks after immunization. SLE patients were scored for disease activity by SLEDAI before and after receiving the vaccine. We also studied antibody titers in SLE patients according to the use of glucocorticoid, methotrexate and azathioprine. RESULTS: Seroprotection after vaccination was equal in SLE patients and healthy controls although seroconvertion was lower in SLE patients for one of the three antigens tested. No significant increase in SLEDAI was observed. Medications such as methotrexate and azathioprine did not change the mean titers of antibody response but glucocorticoids did affect the response to one of the antigens. CONCLUSIONS: Although immune response to influenza vaccine in SLE patients may be diminished it is safe and effective. SN - 0303-464X UR - https://www.unboundmedicine.com/medline/citation/19820674/Safety_and_efficiency_of_influenza_vaccination_in_systemic_lupus_erythematosus_patients_ L2 - http://arp.spreumatologia.pt/download.php?filename=ARP_2009_3_498_10_Influenza_ARP2009_16AO.pdf DB - PRIME DP - Unbound Medicine ER -