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Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition.
Int J Cancer 2010; 126(10):2404-15IJ

Abstract

We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m2, obesity (BMI > or = 30 kg/m2) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% CI = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR = 1.59, 95% CI = 1.20-2.10; p(trend) = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% CI = 0.65-2.06; p(trend) = 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat distribution assessed by waist circumference, waist-hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit increment = 1.17, 95% CI = 1.00-1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women.

Authors+Show Affiliations

Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19821492

Citation

Lahmann, Petra H., et al. "Anthropometric Measures and Epithelial Ovarian Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition." International Journal of Cancer, vol. 126, no. 10, 2010, pp. 2404-15.
Lahmann PH, Cust AE, Friedenreich CM, et al. Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2010;126(10):2404-15.
Lahmann, P. H., Cust, A. E., Friedenreich, C. M., Schulz, M., Lukanova, A., Kaaks, R., ... Riboli, E. (2010). Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 126(10), pp. 2404-15. doi:10.1002/ijc.24952.
Lahmann PH, et al. Anthropometric Measures and Epithelial Ovarian Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition. Int J Cancer. 2010 May 15;126(10):2404-15. PubMed PMID: 19821492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition. AU - Lahmann,Petra H, AU - Cust,Anne E, AU - Friedenreich,Christine M, AU - Schulz,Mandy, AU - Lukanova,Annekatrin, AU - Kaaks,Rudolf, AU - Lundin,Eva, AU - Tjønneland,Anne, AU - Halkjaer,Jytte, AU - Severinsen,Marianne Tang, AU - Overvad,Kim, AU - Fournier,Agnès, AU - Chabbert-Buffet,Nathalie, AU - Clavel-Chapelon,Françoise, AU - Dossus,Laure, AU - Pischon,Tobias, AU - Boeing,Heiner, AU - Trichopoulou,Antonia, AU - Lagiou,Pagona, AU - Naska,Androniki, AU - Palli,Domenico, AU - Grioni,Sara, AU - Mattiello,Amalia, AU - Tumino,Rosario, AU - Sacerdote,Carlotta, AU - Redondo,María-Luisa, AU - Jakszyn,Paula, AU - Sánchez,María-José, AU - Tormo,María-José, AU - Ardanaz,Eva, AU - Arriola,Larraitz, AU - Manjer,Jonas, AU - Jirström,Karin, AU - Bueno-de-Mesquita,H Bas, AU - May,Anne M, AU - Peeters,Petra H M, AU - Onland-Moret,N Charlotte, AU - Bingham,Sheila, AU - Khaw,Kay-Tee, AU - Allen,Naomi E, AU - Spencer,Elizabeth, AU - Rinaldi,Sabina, AU - Slimani,Nadia, AU - Chajes,Véronique, AU - Michaud,Dominique, AU - Norat,Teresa, AU - Riboli,Elio, PY - 2009/10/13/entrez PY - 2009/10/13/pubmed PY - 2010/4/23/medline SP - 2404 EP - 15 JF - International journal of cancer JO - Int. J. Cancer VL - 126 IS - 10 N2 - We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow-up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m2, obesity (BMI > or = 30 kg/m2) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% CI = 1.05-1.68; p(trend) = 0.02) and postmenopausal women (HR = 1.59, 95% CI = 1.20-2.10; p(trend) = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% CI = 0.65-2.06; p(trend) = 0.65). Neither height or weight gain, nor BMI-adjusted measures of fat distribution assessed by waist circumference, waist-hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMI-adjusted HR per 0.05 unit increment = 1.17, 95% CI = 1.00-1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/19821492/Anthropometric_measures_and_epithelial_ovarian_cancer_risk_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition_ L2 - https://doi.org/10.1002/ijc.24952 DB - PRIME DP - Unbound Medicine ER -