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Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects.
Arch Biochem Biophys. 2009 Dec; 492(1-2):1-9.AB

Abstract

Evidence suggests that a group of phytochemicals known as flavonoids are highly effective in reversing age-related declines in neuro-cognitive performance through their ability to interact with the cellular and molecular architecture of the brain responsible for memory and by reducing neuronal loss due to neurodegenerative processes. In particular, they may increase the number of, and strength of, connections between neurons, via their specific interactions with the ERK and Akt signalling pathways, leading to an increase in neurotrophins such as BDNF. Concurrently, their effects on the peripheral and cerebral vascular system may also lead to enhancements in cognitive performance through increased brain blood flow and an ability to initiate neurogenesis in the hippocampus. Finally, they have also been shown to reduce neuronal damage and losses induced by various neurotoxic species and neuroinflammation. Together, these processes act to maintain the number and quality of synaptic connections in the brain, a factor known to be essential for efficient LTP, synaptic plasticity and ultimately the efficient working of memory.

Authors+Show Affiliations

Molecular Nutrition Group, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG66AP, UK. j.p.e.spencer@reading.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19822127

Citation

Spencer, Jeremy P E., et al. "Flavonoids and Cognition: the Molecular Mechanisms Underlying Their Behavioural Effects." Archives of Biochemistry and Biophysics, vol. 492, no. 1-2, 2009, pp. 1-9.
Spencer JP, Vauzour D, Rendeiro C. Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects. Arch Biochem Biophys. 2009;492(1-2):1-9.
Spencer, J. P., Vauzour, D., & Rendeiro, C. (2009). Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects. Archives of Biochemistry and Biophysics, 492(1-2), 1-9. https://doi.org/10.1016/j.abb.2009.10.003
Spencer JP, Vauzour D, Rendeiro C. Flavonoids and Cognition: the Molecular Mechanisms Underlying Their Behavioural Effects. Arch Biochem Biophys. 2009;492(1-2):1-9. PubMed PMID: 19822127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects. AU - Spencer,Jeremy P E, AU - Vauzour,David, AU - Rendeiro,Catarina, Y1 - 2009/10/12/ PY - 2009/08/04/received PY - 2009/10/05/revised PY - 2009/10/06/accepted PY - 2009/10/14/entrez PY - 2009/10/14/pubmed PY - 2009/12/18/medline SP - 1 EP - 9 JF - Archives of biochemistry and biophysics JO - Arch Biochem Biophys VL - 492 IS - 1-2 N2 - Evidence suggests that a group of phytochemicals known as flavonoids are highly effective in reversing age-related declines in neuro-cognitive performance through their ability to interact with the cellular and molecular architecture of the brain responsible for memory and by reducing neuronal loss due to neurodegenerative processes. In particular, they may increase the number of, and strength of, connections between neurons, via their specific interactions with the ERK and Akt signalling pathways, leading to an increase in neurotrophins such as BDNF. Concurrently, their effects on the peripheral and cerebral vascular system may also lead to enhancements in cognitive performance through increased brain blood flow and an ability to initiate neurogenesis in the hippocampus. Finally, they have also been shown to reduce neuronal damage and losses induced by various neurotoxic species and neuroinflammation. Together, these processes act to maintain the number and quality of synaptic connections in the brain, a factor known to be essential for efficient LTP, synaptic plasticity and ultimately the efficient working of memory. SN - 1096-0384 UR - https://www.unboundmedicine.com/medline/citation/19822127/Flavonoids_and_cognition:_the_molecular_mechanisms_underlying_their_behavioural_effects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9861(09)00332-4 DB - PRIME DP - Unbound Medicine ER -