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MicroRNAs: novel therapeutic targets in neurodegenerative diseases.
Drug Discov Today. 2009 Dec; 14(23-24):1123-9.DD

Abstract

The prevalence of neurodegenerative disorders is rising steadily as human life expectancy increases. However, limited knowledge of the molecular basis of disease pathogenesis is a major hurdle in the identification of drug targets and development of therapeutic strategies for these largely incurable disorders. Recently, differential expression of endogenous regulatory small RNAs, known as 'microRNAs' (miRNAs), in patients of Alzheimer's disease, Parkinson's disease and models of ataxia suggest that they might have key regulatory roles in neurodegeneration. miRNAs that can target known mediators of neurodegeneration offer potential therapeutic targets. Our bioinformatic analysis suggests novel miRNA-target interactions that could potentially influence neurodegeneration. The recent development of molecules that alter miRNA expression promises valuable tools that will enhance the therapeutic potential of miRNAs.

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Authors+Show Affiliations

Roshan R
Institute of Genomics and Integrative Biology, Delhi, India.
Ghosh T
No affiliation info available
Scaria V
No affiliation info available
Pillai B
No affiliation info available

MeSH

AnimalsBrainGenetic Predisposition to DiseaseHumansMicroRNAsNeurodegenerative Diseases

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19822222

Citation

Roshan, Reema, et al. "MicroRNAs: Novel Therapeutic Targets in Neurodegenerative Diseases." Drug Discovery Today, vol. 14, no. 23-24, 2009, pp. 1123-9.
Roshan R, Ghosh T, Scaria V, et al. MicroRNAs: novel therapeutic targets in neurodegenerative diseases. Drug Discov Today. 2009;14(23-24):1123-9.
Roshan, R., Ghosh, T., Scaria, V., & Pillai, B. (2009). MicroRNAs: novel therapeutic targets in neurodegenerative diseases. Drug Discovery Today, 14(23-24), 1123-9. https://doi.org/10.1016/j.drudis.2009.09.009
Roshan R, et al. MicroRNAs: Novel Therapeutic Targets in Neurodegenerative Diseases. Drug Discov Today. 2009;14(23-24):1123-9. PubMed PMID: 19822222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MicroRNAs: novel therapeutic targets in neurodegenerative diseases. AU - Roshan,Reema, AU - Ghosh,Tanay, AU - Scaria,Vinod, AU - Pillai,Beena, Y1 - 2009/10/12/ PY - 2009/05/12/received PY - 2009/09/11/revised PY - 2009/09/15/accepted PY - 2009/10/14/entrez PY - 2009/10/14/pubmed PY - 2010/3/20/medline SP - 1123 EP - 9 JF - Drug discovery today JO - Drug Discov Today VL - 14 IS - 23-24 N2 - The prevalence of neurodegenerative disorders is rising steadily as human life expectancy increases. However, limited knowledge of the molecular basis of disease pathogenesis is a major hurdle in the identification of drug targets and development of therapeutic strategies for these largely incurable disorders. Recently, differential expression of endogenous regulatory small RNAs, known as 'microRNAs' (miRNAs), in patients of Alzheimer's disease, Parkinson's disease and models of ataxia suggest that they might have key regulatory roles in neurodegeneration. miRNAs that can target known mediators of neurodegeneration offer potential therapeutic targets. Our bioinformatic analysis suggests novel miRNA-target interactions that could potentially influence neurodegeneration. The recent development of molecules that alter miRNA expression promises valuable tools that will enhance the therapeutic potential of miRNAs. SN - 1878-5832 UR - https://www.unboundmedicine.com/medline/citation/19822222/MicroRNAs:_novel_therapeutic_targets_in_neurodegenerative_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1359-6446(09)00334-1 DB - PRIME DP - Unbound Medicine ER -