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Radiotherapy after surgical resection for head and neck mucosal melanoma.
Am J Clin Oncol. 2010 Jun; 33(3):281-5.AJ

Abstract

OBJECTIVES

To present our single-institution experience with postoperative radiotherapy for mucosal melanoma of the head and neck.

METHODS

Between 1992 and 2007, 27 patients with mucosal melanoma of the head and neck underwent surgical resection followed by postoperative radiotherapy. Median age was 68 years (range: 45-89 years). Sites included were sinonasal in 24 patients, oral cavity in 2, and oropharynx in 1. All but 2 patients had stage I disease. Twenty-two patients received hypofractionated radiation. Radiation techniques were intensity-modulated radiation therapy in 13, 3-dimensional conformal in 4, and conventional in 10.

RESULTS

The median follow-up for living patients was 45 months (range: 24-122 months). The 3- and 5-year estimates of local progression-free, loco-regional progression-free, distant metastasis-free, and overall survival were: 47% and 35%; 34% and 22%; 30% and 24%; and 40% and 33%, respectively. Median time to local failure and distant metastasis was 32 and 14 months, respectively. Acute toxicities included 19% with grade 2 or higher mucositis. No late complications related to the optic structures were seen.

CONCLUSIONS

Modern radiotherapeutic techniques including intensity-modulated radiation therapy appear feasible and well-tolerated in the postoperative treatment of head and neck mucosal melanoma. Unusual or serious late complications have not been observed despite extensive use of hypofractionated regimens. However, rates of local and distant failure remain high.

Authors+Show Affiliations

Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10065, USA. wua@mskcc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19823070

Citation

Wu, Abraham J., et al. "Radiotherapy After Surgical Resection for Head and Neck Mucosal Melanoma." American Journal of Clinical Oncology, vol. 33, no. 3, 2010, pp. 281-5.
Wu AJ, Gomez J, Zhung JE, et al. Radiotherapy after surgical resection for head and neck mucosal melanoma. Am J Clin Oncol. 2010;33(3):281-5.
Wu, A. J., Gomez, J., Zhung, J. E., Chan, K., Gomez, D. R., Wolden, S. L., Zelefsky, M. J., Wolchok, J. D., Carvajal, R. D., Chapman, P. B., Wong, R. J., Shaha, A. R., Kraus, D. H., Shah, J. P., & Lee, N. Y. (2010). Radiotherapy after surgical resection for head and neck mucosal melanoma. American Journal of Clinical Oncology, 33(3), 281-5. https://doi.org/10.1097/COC.0b013e3181a879f5
Wu AJ, et al. Radiotherapy After Surgical Resection for Head and Neck Mucosal Melanoma. Am J Clin Oncol. 2010;33(3):281-5. PubMed PMID: 19823070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radiotherapy after surgical resection for head and neck mucosal melanoma. AU - Wu,Abraham J, AU - Gomez,Jennifer, AU - Zhung,Joanne E, AU - Chan,Kelvin, AU - Gomez,Daniel R, AU - Wolden,Suzanne L, AU - Zelefsky,Michael J, AU - Wolchok,Jedd D, AU - Carvajal,Richard D, AU - Chapman,Paul B, AU - Wong,Richard J, AU - Shaha,Ashok R, AU - Kraus,Dennis H, AU - Shah,Jatin P, AU - Lee,Nancy Y, PY - 2009/10/14/entrez PY - 2009/10/14/pubmed PY - 2010/6/29/medline SP - 281 EP - 5 JF - American journal of clinical oncology JO - Am J Clin Oncol VL - 33 IS - 3 N2 - OBJECTIVES: To present our single-institution experience with postoperative radiotherapy for mucosal melanoma of the head and neck. METHODS: Between 1992 and 2007, 27 patients with mucosal melanoma of the head and neck underwent surgical resection followed by postoperative radiotherapy. Median age was 68 years (range: 45-89 years). Sites included were sinonasal in 24 patients, oral cavity in 2, and oropharynx in 1. All but 2 patients had stage I disease. Twenty-two patients received hypofractionated radiation. Radiation techniques were intensity-modulated radiation therapy in 13, 3-dimensional conformal in 4, and conventional in 10. RESULTS: The median follow-up for living patients was 45 months (range: 24-122 months). The 3- and 5-year estimates of local progression-free, loco-regional progression-free, distant metastasis-free, and overall survival were: 47% and 35%; 34% and 22%; 30% and 24%; and 40% and 33%, respectively. Median time to local failure and distant metastasis was 32 and 14 months, respectively. Acute toxicities included 19% with grade 2 or higher mucositis. No late complications related to the optic structures were seen. CONCLUSIONS: Modern radiotherapeutic techniques including intensity-modulated radiation therapy appear feasible and well-tolerated in the postoperative treatment of head and neck mucosal melanoma. Unusual or serious late complications have not been observed despite extensive use of hypofractionated regimens. However, rates of local and distant failure remain high. SN - 1537-453X UR - https://www.unboundmedicine.com/medline/citation/19823070/Radiotherapy_after_surgical_resection_for_head_and_neck_mucosal_melanoma_ L2 - https://doi.org/10.1097/COC.0b013e3181a879f5 DB - PRIME DP - Unbound Medicine ER -