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High-dose naproxen aggravates pancreatic fibrosis in a rat model of chronic pancreatitis.
Pancreas. 2010 Apr; 39(3):293-300.P

Abstract

OBJECTIVES

: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for the treatment of pain in chronic pancreatitis (CP). This study aimed to investigate the effect of NSAIDs on the inflammation and fibrosis progression in trinitrobenzene sulfonic acid-induced CP rats.

METHODS

Chronic pancreatitis was induced by trinitrobenzene sulfonic acid infusion into rat pancreatic ducts. Naproxen treatment (20 and 40 mg/kg per os [PO] and intraperitoneally) started 2 weeks after the induction of CP for 3 weeks. Histological analysis of the pancreas, Van Gieson staining, and contents of hydroxyproline were used to evaluate pancreatic damage and fibrosis. Furthermore, the effect of naproxen on nociceptive reflective behaviors and serum tumor necrosis factor alpha concentration were studied, and immunohistochemical analysis of alpha-smooth muscle actin in the pancreas was performed.

RESULTS

Pancreatic collagen content and alpha-smooth muscle actin expression were higher in the CP group treated with high-dose (40 mg/kg PO) naproxen (P < 0.05). High-dose naproxen administered orally aggravated pancreatic fibrosis and inflammation (P < 0.05). Instead of playing an analgesic role, high-dose naproxen decreased the thermal withdrawal latencies in CP rats (P < 0.05).

CONCLUSIONS

High-dose naproxen treatment (40 mg/kg PO) aggravated pancreatic fibrosis in CP rats and played an algogenic role that suggests the potential risk of long-term use of NSAIDs as analgesic in clinical practice with CP.

Authors+Show Affiliations

Division of Field Medicine, Department of Internal Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19823098

Citation

Zhang, Wei, et al. "High-dose Naproxen Aggravates Pancreatic Fibrosis in a Rat Model of Chronic Pancreatitis." Pancreas, vol. 39, no. 3, 2010, pp. 293-300.
Zhang W, Gao J, Zhao T, et al. High-dose naproxen aggravates pancreatic fibrosis in a rat model of chronic pancreatitis. Pancreas. 2010;39(3):293-300.
Zhang, W., Gao, J., Zhao, T., Wu, W., Bai, Y., Zou, D., & Li, Z. (2010). High-dose naproxen aggravates pancreatic fibrosis in a rat model of chronic pancreatitis. Pancreas, 39(3), 293-300. https://doi.org/10.1097/MPA.0b013e3181bb90b5
Zhang W, et al. High-dose Naproxen Aggravates Pancreatic Fibrosis in a Rat Model of Chronic Pancreatitis. Pancreas. 2010;39(3):293-300. PubMed PMID: 19823098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-dose naproxen aggravates pancreatic fibrosis in a rat model of chronic pancreatitis. AU - Zhang,Wei, AU - Gao,Jun, AU - Zhao,Tao, AU - Wu,Wenbin, AU - Bai,Yu, AU - Zou,Duowu, AU - Li,Zhaoshen, PY - 2009/10/14/entrez PY - 2009/10/14/pubmed PY - 2010/7/9/medline SP - 293 EP - 300 JF - Pancreas JO - Pancreas VL - 39 IS - 3 N2 - OBJECTIVES: : Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for the treatment of pain in chronic pancreatitis (CP). This study aimed to investigate the effect of NSAIDs on the inflammation and fibrosis progression in trinitrobenzene sulfonic acid-induced CP rats. METHODS: Chronic pancreatitis was induced by trinitrobenzene sulfonic acid infusion into rat pancreatic ducts. Naproxen treatment (20 and 40 mg/kg per os [PO] and intraperitoneally) started 2 weeks after the induction of CP for 3 weeks. Histological analysis of the pancreas, Van Gieson staining, and contents of hydroxyproline were used to evaluate pancreatic damage and fibrosis. Furthermore, the effect of naproxen on nociceptive reflective behaviors and serum tumor necrosis factor alpha concentration were studied, and immunohistochemical analysis of alpha-smooth muscle actin in the pancreas was performed. RESULTS: Pancreatic collagen content and alpha-smooth muscle actin expression were higher in the CP group treated with high-dose (40 mg/kg PO) naproxen (P < 0.05). High-dose naproxen administered orally aggravated pancreatic fibrosis and inflammation (P < 0.05). Instead of playing an analgesic role, high-dose naproxen decreased the thermal withdrawal latencies in CP rats (P < 0.05). CONCLUSIONS: High-dose naproxen treatment (40 mg/kg PO) aggravated pancreatic fibrosis in CP rats and played an algogenic role that suggests the potential risk of long-term use of NSAIDs as analgesic in clinical practice with CP. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/19823098/High_dose_naproxen_aggravates_pancreatic_fibrosis_in_a_rat_model_of_chronic_pancreatitis_ L2 - https://doi.org/10.1097/MPA.0b013e3181bb90b5 DB - PRIME DP - Unbound Medicine ER -