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The effect of chronic administration of nicotine and withdrawal on somatostatin concentration and binding in brain of rat.
Neuropharmacology. 1990 Nov; 29(11):1025-30.N

Abstract

The effects of chronic administration of nicotine (20 or 30 days) and its withdrawal on somatostatin-like immunorectivity and the binding of 125I-Tyr11-somatostatin in the frontoparietal cortex and hippocampus of the rat were investigated. Chronic administration of nicotine resulted in a decrease in the total number of specific somatostatin receptors, while the affinity of the receptors was unaltered and somatostatin-like immunoreactivity was unchanged in both areas of the brain. Three weeks after ending chronic exposure to nicotine in the second experimental group, the number of somatostatin receptors had returned to the same values as those of saline-treated rats.

Authors+Show Affiliations

Barrios V
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Alcalá, Madrid, Spain.
Rodríguez-Sánchez MN
No affiliation info available
Arilla E
No affiliation info available

MeSH

AnimalsBinding, CompetitiveBrainDrug Administration ScheduleHippocampusKineticsMaleMecamylamineNicotineOrgan SpecificityParietal LobeRatsRats, Inbred StrainsReceptors, NeurotransmitterReceptors, SomatostatinReference ValuesSomatostatinSubstance Withdrawal SyndromeSubstance-Related Disorders

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1982338

Citation

Barrios, V, et al. "The Effect of Chronic Administration of Nicotine and Withdrawal On Somatostatin Concentration and Binding in Brain of Rat." Neuropharmacology, vol. 29, no. 11, 1990, pp. 1025-30.
Barrios V, Rodríguez-Sánchez MN, Arilla E. The effect of chronic administration of nicotine and withdrawal on somatostatin concentration and binding in brain of rat. Neuropharmacology. 1990;29(11):1025-30.
Barrios, V., Rodríguez-Sánchez, M. N., & Arilla, E. (1990). The effect of chronic administration of nicotine and withdrawal on somatostatin concentration and binding in brain of rat. Neuropharmacology, 29(11), 1025-30.
Barrios V, Rodríguez-Sánchez MN, Arilla E. The Effect of Chronic Administration of Nicotine and Withdrawal On Somatostatin Concentration and Binding in Brain of Rat. Neuropharmacology. 1990;29(11):1025-30. PubMed PMID: 1982338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of chronic administration of nicotine and withdrawal on somatostatin concentration and binding in brain of rat. AU - Barrios,V, AU - Rodríguez-Sánchez,M N, AU - Arilla,E, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 1025 EP - 30 JF - Neuropharmacology JO - Neuropharmacology VL - 29 IS - 11 N2 - The effects of chronic administration of nicotine (20 or 30 days) and its withdrawal on somatostatin-like immunorectivity and the binding of 125I-Tyr11-somatostatin in the frontoparietal cortex and hippocampus of the rat were investigated. Chronic administration of nicotine resulted in a decrease in the total number of specific somatostatin receptors, while the affinity of the receptors was unaltered and somatostatin-like immunoreactivity was unchanged in both areas of the brain. Three weeks after ending chronic exposure to nicotine in the second experimental group, the number of somatostatin receptors had returned to the same values as those of saline-treated rats. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/1982338/The_effect_of_chronic_administration_of_nicotine_and_withdrawal_on_somatostatin_concentration_and_binding_in_brain_of_rat_ DB - PRIME DP - Unbound Medicine ER -