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Alcohol consumption and the risk of coronary heart disease in postmenopausal women with diabetes: Women's Health Initiative Observational Study.
Eur J Nutr 2010; 49(4):211-8EJ

Abstract

BACKGROUND

Although several observational studies have consistently reported an inverse association between moderate alcohol consumption and risk of coronary heart disease (CHD), it is yet not well established if this association also exists among people with type 2 diabetes. The aim of this study is to evaluate the association between the frequency and quantity of alcohol intake and the risk of developing CHD among postmenopausal women with diabetes.

METHODS

We conducted a prospective cohort study, which included 3,198 women with self-reported diabetes and without any history of cardiovascular disease at baseline, in the Women's Health Initiative Observational Study. Alcohol intake was assessed by a semiquantitative food frequency questionnaire. The primary outcome of this study was CHD, which was validated by medical record review. Cox proportional hazards regression was used to estimate the hazard ratio (HR) for the association of alcohol intake and risk of incident CHD while adjusting for several potential confounders.

RESULTS

During the 22,546 person-years of follow-up, there were 336 incident cases of CHD. Both frequency and quantity of alcohol intake were inversely associated with the risk of developing CHD. Compared to nondrinkers, the multivariable HRs across categories of frequency of alcohol consumption (<or=0.5, 0.5-2 and >or=2 drinks/week) were 0.89 (95% confidence intervals [CI]: 0.63, 1.26), 0.84 (95% CI: 0.56, 1.25) and 0.65 (95% CI: 0.43, 0.99), respectively (p for trend: 0.04). This association did not appear to differ based on the type of the alcoholic beverage consumed.

CONCLUSIONS

Moderate alcohol consumption of postmenopausal women with type 2 diabetes may have a benefit on CHD similar to that seen in postmenopausal nondiabetic women. The potential risks of alcohol on noncardiac outcomes may need consideration when recommending alcohol to women with diabetes.

Authors+Show Affiliations

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA. swapnil.rajpathak@einstein.yu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19823890

Citation

Rajpathak, Swapnil N., et al. "Alcohol Consumption and the Risk of Coronary Heart Disease in Postmenopausal Women With Diabetes: Women's Health Initiative Observational Study." European Journal of Nutrition, vol. 49, no. 4, 2010, pp. 211-8.
Rajpathak SN, Freiberg MS, Wang C, et al. Alcohol consumption and the risk of coronary heart disease in postmenopausal women with diabetes: Women's Health Initiative Observational Study. Eur J Nutr. 2010;49(4):211-8.
Rajpathak, S. N., Freiberg, M. S., Wang, C., Wylie-Rosett, J., Wildman, R. P., Rohan, T. E., ... Wassertheil-Smoller, S. (2010). Alcohol consumption and the risk of coronary heart disease in postmenopausal women with diabetes: Women's Health Initiative Observational Study. European Journal of Nutrition, 49(4), pp. 211-8. doi:10.1007/s00394-009-0065-3.
Rajpathak SN, et al. Alcohol Consumption and the Risk of Coronary Heart Disease in Postmenopausal Women With Diabetes: Women's Health Initiative Observational Study. Eur J Nutr. 2010;49(4):211-8. PubMed PMID: 19823890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and the risk of coronary heart disease in postmenopausal women with diabetes: Women's Health Initiative Observational Study. AU - Rajpathak,Swapnil N, AU - Freiberg,Mathew S, AU - Wang,Cuiling, AU - Wylie-Rosett,Judith, AU - Wildman,Rachel P, AU - Rohan,Thomas E, AU - Robinson,Jennifer G, AU - Liu,Simin, AU - Wassertheil-Smoller,Sylvia, Y1 - 2009/10/13/ PY - 2009/08/03/received PY - 2009/10/01/accepted PY - 2009/10/14/entrez PY - 2009/10/14/pubmed PY - 2010/9/2/medline SP - 211 EP - 8 JF - European journal of nutrition JO - Eur J Nutr VL - 49 IS - 4 N2 - BACKGROUND: Although several observational studies have consistently reported an inverse association between moderate alcohol consumption and risk of coronary heart disease (CHD), it is yet not well established if this association also exists among people with type 2 diabetes. The aim of this study is to evaluate the association between the frequency and quantity of alcohol intake and the risk of developing CHD among postmenopausal women with diabetes. METHODS: We conducted a prospective cohort study, which included 3,198 women with self-reported diabetes and without any history of cardiovascular disease at baseline, in the Women's Health Initiative Observational Study. Alcohol intake was assessed by a semiquantitative food frequency questionnaire. The primary outcome of this study was CHD, which was validated by medical record review. Cox proportional hazards regression was used to estimate the hazard ratio (HR) for the association of alcohol intake and risk of incident CHD while adjusting for several potential confounders. RESULTS: During the 22,546 person-years of follow-up, there were 336 incident cases of CHD. Both frequency and quantity of alcohol intake were inversely associated with the risk of developing CHD. Compared to nondrinkers, the multivariable HRs across categories of frequency of alcohol consumption (<or=0.5, 0.5-2 and >or=2 drinks/week) were 0.89 (95% confidence intervals [CI]: 0.63, 1.26), 0.84 (95% CI: 0.56, 1.25) and 0.65 (95% CI: 0.43, 0.99), respectively (p for trend: 0.04). This association did not appear to differ based on the type of the alcoholic beverage consumed. CONCLUSIONS: Moderate alcohol consumption of postmenopausal women with type 2 diabetes may have a benefit on CHD similar to that seen in postmenopausal nondiabetic women. The potential risks of alcohol on noncardiac outcomes may need consideration when recommending alcohol to women with diabetes. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/19823890/Alcohol_consumption_and_the_risk_of_coronary_heart_disease_in_postmenopausal_women_with_diabetes:_Women's_Health_Initiative_Observational_Study_ L2 - https://dx.doi.org/10.1007/s00394-009-0065-3 DB - PRIME DP - Unbound Medicine ER -