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Effects of four dopamine agonists on l-tetrahydropalmatine-induced analgesia and electroacupuncture analgesia in rabbits.
Zhongguo Yao Li Xue Bao. 1990 May; 11(3):196-200.ZY

Abstract

The effects of icv 4 dopamine (DA) agonists on analgesia caused by iv l-tetrahydropalmatine (THP) 8 mg/kg or by electro-acupuncture (EA) were studied by using the potassium iontophoretic dolorimetry in rabbits. The results showed that both THP-induced analgesia and EA analgesia were markedly attenuated by icv of DA or apomorphine (Apo), 2 mixed D1/D2 agonists. Similar results were obtained when SKF-38393, a selective D1 agonist, was applied. On the contrary, quinpirole hydrochloride (Qui), a selective D2 agonist, was found to enhance the analgesic action of THP or EA. However, DA, Apo, SKF-38393 or Qui per se did not influence the baseline pain threshold. All these observations indicate that functional alterations in DA receptor activities may be involved in THP-induced analgesia and EA analgesia, in which D1 and D2 subtype receptors exert different roles.

Authors+Show Affiliations

Department of Neurobiology, Shanghai Medical University, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1982393

Citation

Wu, G, et al. "Effects of Four Dopamine Agonists On L-tetrahydropalmatine-induced Analgesia and Electroacupuncture Analgesia in Rabbits." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, vol. 11, no. 3, 1990, pp. 196-200.
Wu G, Jiang JW, Wu GC, et al. Effects of four dopamine agonists on l-tetrahydropalmatine-induced analgesia and electroacupuncture analgesia in rabbits. Zhongguo Yao Li Xue Bao. 1990;11(3):196-200.
Wu, G., Jiang, J. W., Wu, G. C., & Cao, X. D. (1990). Effects of four dopamine agonists on l-tetrahydropalmatine-induced analgesia and electroacupuncture analgesia in rabbits. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, 11(3), 196-200.
Wu G, et al. Effects of Four Dopamine Agonists On L-tetrahydropalmatine-induced Analgesia and Electroacupuncture Analgesia in Rabbits. Zhongguo Yao Li Xue Bao. 1990;11(3):196-200. PubMed PMID: 1982393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of four dopamine agonists on l-tetrahydropalmatine-induced analgesia and electroacupuncture analgesia in rabbits. AU - Wu,G, AU - Jiang,J W, AU - Wu,G C, AU - Cao,X D, PY - 1990/5/1/pubmed PY - 1990/5/1/medline PY - 1990/5/1/entrez SP - 196 EP - 200 JF - Zhongguo yao li xue bao = Acta pharmacologica Sinica JO - Zhongguo Yao Li Xue Bao VL - 11 IS - 3 N2 - The effects of icv 4 dopamine (DA) agonists on analgesia caused by iv l-tetrahydropalmatine (THP) 8 mg/kg or by electro-acupuncture (EA) were studied by using the potassium iontophoretic dolorimetry in rabbits. The results showed that both THP-induced analgesia and EA analgesia were markedly attenuated by icv of DA or apomorphine (Apo), 2 mixed D1/D2 agonists. Similar results were obtained when SKF-38393, a selective D1 agonist, was applied. On the contrary, quinpirole hydrochloride (Qui), a selective D2 agonist, was found to enhance the analgesic action of THP or EA. However, DA, Apo, SKF-38393 or Qui per se did not influence the baseline pain threshold. All these observations indicate that functional alterations in DA receptor activities may be involved in THP-induced analgesia and EA analgesia, in which D1 and D2 subtype receptors exert different roles. SN - 0253-9756 UR - https://www.unboundmedicine.com/medline/citation/1982393/Effects_of_four_dopamine_agonists_on_l_tetrahydropalmatine_induced_analgesia_and_electroacupuncture_analgesia_in_rabbits_ L2 - http://www.chinaphar.com/1671-4083/11/196.pdf DB - PRIME DP - Unbound Medicine ER -