Tags

Type your tag names separated by a space and hit enter

Factors governing single-trial contextual fear conditioning in the weanling rat.
Behav Neurosci. 2009 Oct; 123(5):1148-52.BN

Abstract

Although contextual fear conditioning emerges later in development than explicit-cue fear conditioning, little is known about the stimulus parameters and biological substrates required at early ages. The authors adapted methods for investigating hippocampus function in adult rodents to identify determinants of contextual fear conditioning in developing rats. Experiment 1 examined the duration of exposure required by weanling rats at postnatal day (PND) 23 to demonstrate contextual fear conditioning. This experiment demonstrated that 30 s of context exposure is sufficient to support conditioning. Furthermore, preexposure enhanced conditioning to an immediate footshock, the context preexposure facilitation effect (CPFE), but had no effect on contextual conditioning to a delayed shock. Experiment 2 demonstrated that N-methyl-D-aspartate (NMDA) receptor inactivation during preexposure impairs contextual learning at PND 23. Thus, the conjuctive representations underlying the CPFE are NMDA-dependent as early as PND23 in the rat.

Links

PMC Free PDF
PMC Free Full Text
Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

Burman MA
University of Delaware, Newark, DE 19716, USA. mburman@une.edu
Murawski NJ
No affiliation info available
Schiffino FL
No affiliation info available
Rosen JB
No affiliation info available
Stanton ME
No affiliation info available

MeSH

Analysis of VarianceAnimalsConditioning, ClassicalDizocilpine MaleateElectroshockExcitatory Amino Acid AntagonistsFearFemaleFreezing Reaction, CatalepticMaleRatsRats, Long-EvansReceptors, N-Methyl-D-Aspartate

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19824781

Citation

Burman, M A., et al. "Factors Governing Single-trial Contextual Fear Conditioning in the Weanling Rat." Behavioral Neuroscience, vol. 123, no. 5, 2009, pp. 1148-52.
Burman MA, Murawski NJ, Schiffino FL, et al. Factors governing single-trial contextual fear conditioning in the weanling rat. Behav Neurosci. 2009;123(5):1148-52.
Burman, M. A., Murawski, N. J., Schiffino, F. L., Rosen, J. B., & Stanton, M. E. (2009). Factors governing single-trial contextual fear conditioning in the weanling rat. Behavioral Neuroscience, 123(5), 1148-52. https://doi.org/10.1037/a0016733
Burman MA, et al. Factors Governing Single-trial Contextual Fear Conditioning in the Weanling Rat. Behav Neurosci. 2009;123(5):1148-52. PubMed PMID: 19824781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors governing single-trial contextual fear conditioning in the weanling rat. AU - Burman,M A, AU - Murawski,N J, AU - Schiffino,F L, AU - Rosen,J B, AU - Stanton,M E, PY - 2009/10/15/entrez PY - 2009/10/15/pubmed PY - 2009/11/18/medline SP - 1148 EP - 52 JF - Behavioral neuroscience JO - Behav Neurosci VL - 123 IS - 5 N2 - Although contextual fear conditioning emerges later in development than explicit-cue fear conditioning, little is known about the stimulus parameters and biological substrates required at early ages. The authors adapted methods for investigating hippocampus function in adult rodents to identify determinants of contextual fear conditioning in developing rats. Experiment 1 examined the duration of exposure required by weanling rats at postnatal day (PND) 23 to demonstrate contextual fear conditioning. This experiment demonstrated that 30 s of context exposure is sufficient to support conditioning. Furthermore, preexposure enhanced conditioning to an immediate footshock, the context preexposure facilitation effect (CPFE), but had no effect on contextual conditioning to a delayed shock. Experiment 2 demonstrated that N-methyl-D-aspartate (NMDA) receptor inactivation during preexposure impairs contextual learning at PND 23. Thus, the conjuctive representations underlying the CPFE are NMDA-dependent as early as PND23 in the rat. SN - 1939-0084 UR - https://www.unboundmedicine.com/medline/citation/19824781/Factors_governing_single_trial_contextual_fear_conditioning_in_the_weanling_rat_ L2 - http://content.apa.org/journals/bne/123/5/1148 DB - PRIME DP - Unbound Medicine ER -