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Perturbation of the natural killer cell compartment during primary human immunodeficiency virus 1 infection primarily involving the CD56 bright subset.

Abstract

We investigated the distribution of natural killer (NK) cell subsets, their activating and inhibitory receptors, and their cytolytic potential, in primary human immunodeficiency virus (HIV)-infected (PHI) individuals at baseline and during 1 year of follow-up with or without antiretroviral therapy, and compared the results with those obtained in treatment-naïve, chronically HIV-infected (CHI) individuals, and HIV-seronegative (HN) healthy individuals. The proportion of the CD56(dim) and CD56(bright) subsets decreased with disease progression, whereas that of the CD56(-) CD16(+) subset increased. In the CD56(dim) subset, the proportion of cells with natural cytotoxicity receptors (NCRs) decreased with disease progression, and their cytolytic potential was reduced. Conversely, the CD56(bright) subset was characterized by a high proportion of NCR-positive, killer cell immunoglobulin-like receptor (KIR)-positive NKG2A(+) cells in both CHI and PHI individuals, which was associated with an increase in their cytolytic potential. During the 1 year of follow-up, the PHI individuals with high viraemia levels and low CD4(+) T-cell counts who received highly active antiretroviral therapy (HAART) had a similar proportion of NK subsets to CHI individuals, while patients with low viraemia levels and high CD4(+) T-cell counts who remained untreated had values similar to those of the HN individuals. Our results indicate a marked perturbation of the NK cell compartment during HIV-1 infection that is multifaceted, starts early and is progressive, primarily involves the CD56(bright) subset, and is partially corrected by effective HAART.

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  • Authors+Show Affiliations

    ,

    Division of Immunology, Laboratory of Clinical Immunology, Transplantation and Infectious Diseases, Vita-Salute San Raffaele University, Milan, Italy.

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    Source

    Immunology 129:2 2010 Feb pg 220-33

    MeSH

    Adult
    Antiretroviral Therapy, Highly Active
    CD4-Positive T-Lymphocytes
    CD56 Antigen
    Cell Count
    Cell Separation
    Cytotoxicity, Immunologic
    Flow Cytometry
    Follow-Up Studies
    HIV Infections
    HIV Seronegativity
    HIV-1
    Humans
    Killer Cells, Natural
    Middle Aged
    NK Cell Lectin-Like Receptor Subfamily C
    Receptors, KIR
    Receptors, Natural Cytotoxicity Triggering

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19824914

    Citation

    Mantegani, Paola, et al. "Perturbation of the Natural Killer Cell Compartment During Primary Human Immunodeficiency Virus 1 Infection Primarily Involving the CD56 Bright Subset." Immunology, vol. 129, no. 2, 2010, pp. 220-33.
    Mantegani P, Tambussi G, Galli L, et al. Perturbation of the natural killer cell compartment during primary human immunodeficiency virus 1 infection primarily involving the CD56 bright subset. Immunology. 2010;129(2):220-33.
    Mantegani, P., Tambussi, G., Galli, L., Din, C. T., Lazzarin, A., & Fortis, C. (2010). Perturbation of the natural killer cell compartment during primary human immunodeficiency virus 1 infection primarily involving the CD56 bright subset. Immunology, 129(2), pp. 220-33. doi:10.1111/j.1365-2567.2009.03171.x.
    Mantegani P, et al. Perturbation of the Natural Killer Cell Compartment During Primary Human Immunodeficiency Virus 1 Infection Primarily Involving the CD56 Bright Subset. Immunology. 2010;129(2):220-33. PubMed PMID: 19824914.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Perturbation of the natural killer cell compartment during primary human immunodeficiency virus 1 infection primarily involving the CD56 bright subset. AU - Mantegani,Paola, AU - Tambussi,Giuseppe, AU - Galli,Laura, AU - Din,Chiara Tassan, AU - Lazzarin,Adriano, AU - Fortis,Claudio, Y1 - 2009/08/04/ PY - 2009/10/15/entrez PY - 2009/10/15/pubmed PY - 2010/8/19/medline SP - 220 EP - 33 JF - Immunology JO - Immunology VL - 129 IS - 2 N2 - We investigated the distribution of natural killer (NK) cell subsets, their activating and inhibitory receptors, and their cytolytic potential, in primary human immunodeficiency virus (HIV)-infected (PHI) individuals at baseline and during 1 year of follow-up with or without antiretroviral therapy, and compared the results with those obtained in treatment-naïve, chronically HIV-infected (CHI) individuals, and HIV-seronegative (HN) healthy individuals. The proportion of the CD56(dim) and CD56(bright) subsets decreased with disease progression, whereas that of the CD56(-) CD16(+) subset increased. In the CD56(dim) subset, the proportion of cells with natural cytotoxicity receptors (NCRs) decreased with disease progression, and their cytolytic potential was reduced. Conversely, the CD56(bright) subset was characterized by a high proportion of NCR-positive, killer cell immunoglobulin-like receptor (KIR)-positive NKG2A(+) cells in both CHI and PHI individuals, which was associated with an increase in their cytolytic potential. During the 1 year of follow-up, the PHI individuals with high viraemia levels and low CD4(+) T-cell counts who received highly active antiretroviral therapy (HAART) had a similar proportion of NK subsets to CHI individuals, while patients with low viraemia levels and high CD4(+) T-cell counts who remained untreated had values similar to those of the HN individuals. Our results indicate a marked perturbation of the NK cell compartment during HIV-1 infection that is multifaceted, starts early and is progressive, primarily involves the CD56(bright) subset, and is partially corrected by effective HAART. SN - 1365-2567 UR - https://www.unboundmedicine.com/medline/citation/19824914/Perturbation_of_the_natural_killer_cell_compartment_during_primary_human_immunodeficiency_virus_1_infection_primarily_involving_the_CD56_bright_subset_ L2 - https://doi.org/10.1111/j.1365-2567.2009.03171.x DB - PRIME DP - Unbound Medicine ER -