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Flat epithelial atypia and atypical ductal hyperplasia: carcinoma underestimation rate.
Breast J. 2010 Jan-Feb; 16(1):55-9.BJ

Abstract

This study was carried out to determine the underestimation rate of carcinoma upon surgical biopsy after a diagnosis of flat epithelial atypia and atypical ductal hyperplasia and 11-gauge vacuum-assisted breast biopsy. A retrospective review was conducted of 476 vacuum-assisted breast biopsy performed from May 2005 to January 2007 and a total of 70 cases of atypia were identified. Fifty cases (71%) were categorized as pure atypical ductal hyperplasia, 18 (26%) as pure flat epithelial atypia and two (3%) as concomitant flat epithelial atypia and atypical ductal hyperplasia. Each group were compared with the subsequent open surgical specimens. Surgical biopsy was performed in 44 patients with atypical ductal hyperplasia, 15 patients with flat epithelial atypia, and two patients with flat epithelial atypia and atypical ductal hyperplasia. Five cases of atypical ductal hyperplasia were upgraded to ductal carcinoma in situ, three cases of flat epithelial atypia yielded one ductal carcinoma in situ and two cases of invasive ductal carcinoma, and one case of flat epithelial atypia/atypical ductal hyperplasia had invasive ductal carcinoma. The overall rate of malignancy was 16% for atypical ductal hyperplasia (including flat epithelial atypia/atypical ductal hyperplasia patients) and 20% for flat epithelial atypia. The presence of flat epithelial atypia and atypical ductal hyperplasia at biopsy requires careful consideration, and surgical excision should be suggested.

Authors+Show Affiliations

Department of Clinical Sciences, Section of Radiological Sciences, University of Parma, Italy. annaingegnoli@yahoo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19825003

Citation

Ingegnoli, Anna, et al. "Flat Epithelial Atypia and Atypical Ductal Hyperplasia: Carcinoma Underestimation Rate." The Breast Journal, vol. 16, no. 1, 2010, pp. 55-9.
Ingegnoli A, d'Aloia C, Frattaruolo A, et al. Flat epithelial atypia and atypical ductal hyperplasia: carcinoma underestimation rate. Breast J. 2010;16(1):55-9.
Ingegnoli, A., d'Aloia, C., Frattaruolo, A., Pallavera, L., Martella, E., Crisi, G., & Zompatori, M. (2010). Flat epithelial atypia and atypical ductal hyperplasia: carcinoma underestimation rate. The Breast Journal, 16(1), 55-9. https://doi.org/10.1111/j.1524-4741.2009.00850.x
Ingegnoli A, et al. Flat Epithelial Atypia and Atypical Ductal Hyperplasia: Carcinoma Underestimation Rate. Breast J. 2010 Jan-Feb;16(1):55-9. PubMed PMID: 19825003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flat epithelial atypia and atypical ductal hyperplasia: carcinoma underestimation rate. AU - Ingegnoli,Anna, AU - d'Aloia,Cecilia, AU - Frattaruolo,Antonia, AU - Pallavera,Lara, AU - Martella,Eugenia, AU - Crisi,Girolamo, AU - Zompatori,Maurizio, Y1 - 2009/10/13/ PY - 2009/10/15/entrez PY - 2009/10/15/pubmed PY - 2010/8/18/medline SP - 55 EP - 9 JF - The breast journal JO - Breast J VL - 16 IS - 1 N2 - This study was carried out to determine the underestimation rate of carcinoma upon surgical biopsy after a diagnosis of flat epithelial atypia and atypical ductal hyperplasia and 11-gauge vacuum-assisted breast biopsy. A retrospective review was conducted of 476 vacuum-assisted breast biopsy performed from May 2005 to January 2007 and a total of 70 cases of atypia were identified. Fifty cases (71%) were categorized as pure atypical ductal hyperplasia, 18 (26%) as pure flat epithelial atypia and two (3%) as concomitant flat epithelial atypia and atypical ductal hyperplasia. Each group were compared with the subsequent open surgical specimens. Surgical biopsy was performed in 44 patients with atypical ductal hyperplasia, 15 patients with flat epithelial atypia, and two patients with flat epithelial atypia and atypical ductal hyperplasia. Five cases of atypical ductal hyperplasia were upgraded to ductal carcinoma in situ, three cases of flat epithelial atypia yielded one ductal carcinoma in situ and two cases of invasive ductal carcinoma, and one case of flat epithelial atypia/atypical ductal hyperplasia had invasive ductal carcinoma. The overall rate of malignancy was 16% for atypical ductal hyperplasia (including flat epithelial atypia/atypical ductal hyperplasia patients) and 20% for flat epithelial atypia. The presence of flat epithelial atypia and atypical ductal hyperplasia at biopsy requires careful consideration, and surgical excision should be suggested. SN - 1524-4741 UR - https://www.unboundmedicine.com/medline/citation/19825003/Flat_epithelial_atypia_and_atypical_ductal_hyperplasia:_carcinoma_underestimation_rate_ L2 - https://doi.org/10.1111/j.1524-4741.2009.00850.x DB - PRIME DP - Unbound Medicine ER -