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Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study.
Br J Nutr 2010; 103(4):602-7BJ

Abstract

Dietary intake of marine n-3 PUFA has been negatively associated with the risk of CHD among subjects with known CHD, whereas an effect in healthy subjects is less documented. We assessed the hypothesis that dietary intake of marine n-3 PUFA is negatively associated with the risk of acute coronary syndrome (ACS) in healthy subjects. In the Danish Diet, Cancer and Health cohort study, 57 053 participants were enrolled. Dietary intake of total n-3 PUFA, including EPA, docosapentaenoic acid (DPA) and DHA, was assessed. During a mean follow-up period of 7.6 years, we identified all cases (n 1150) from this cohort with an incident ACS diagnosis in the Danish National Patient Registry or the Cause of Death Registry. Diagnoses were verified through medical record review. In Cox proportional hazard models, we adjusted for established risk factors for CHD. Men in the four highest quintiles of n-3 PUFA intake (>0.39 g n-3 PUFA per d) had a lower incidence of ACS compared with men in the lowest quintile. The hazard ratio was 0.83 (95 % CI 0.67, 1.03) when we compared men in the second lowest and lowest quintile of n-3 PUFA intake. Higher intake of n-3 PUFA did not strengthen this association. Associations for EPA, DPA and DHA were all negative, but less consistent. No convincing associations were found among women. In conclusion, we found borderline significant negative associations between the intake of marine n-3 PUFA and ACS among healthy men.

Authors+Show Affiliations

Department of Cardiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. albert.marni.joensen@rn.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19825219

Citation

Joensen, Albert M., et al. "Dietary Intake of Total Marine N-3 Polyunsaturated Fatty Acids, Eicosapentaenoic Acid, Docosahexaenoic Acid and Docosapentaenoic Acid and the Risk of Acute Coronary Syndrome - a Cohort Study." The British Journal of Nutrition, vol. 103, no. 4, 2010, pp. 602-7.
Joensen AM, Schmidt EB, Dethlefsen C, et al. Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study. Br J Nutr. 2010;103(4):602-7.
Joensen, A. M., Schmidt, E. B., Dethlefsen, C., Johnsen, S. P., Tjønneland, A., Rasmussen, L. H., & Overvad, K. (2010). Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study. The British Journal of Nutrition, 103(4), pp. 602-7. doi:10.1017/S0007114509992170.
Joensen AM, et al. Dietary Intake of Total Marine N-3 Polyunsaturated Fatty Acids, Eicosapentaenoic Acid, Docosahexaenoic Acid and Docosapentaenoic Acid and the Risk of Acute Coronary Syndrome - a Cohort Study. Br J Nutr. 2010;103(4):602-7. PubMed PMID: 19825219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study. AU - Joensen,Albert M, AU - Schmidt,Erik B, AU - Dethlefsen,Claus, AU - Johnsen,Søren P, AU - Tjønneland,Anne, AU - Rasmussen,Lars H, AU - Overvad,Kim, Y1 - 2009/10/14/ PY - 2009/10/15/entrez PY - 2009/10/15/pubmed PY - 2010/3/5/medline SP - 602 EP - 7 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 103 IS - 4 N2 - Dietary intake of marine n-3 PUFA has been negatively associated with the risk of CHD among subjects with known CHD, whereas an effect in healthy subjects is less documented. We assessed the hypothesis that dietary intake of marine n-3 PUFA is negatively associated with the risk of acute coronary syndrome (ACS) in healthy subjects. In the Danish Diet, Cancer and Health cohort study, 57 053 participants were enrolled. Dietary intake of total n-3 PUFA, including EPA, docosapentaenoic acid (DPA) and DHA, was assessed. During a mean follow-up period of 7.6 years, we identified all cases (n 1150) from this cohort with an incident ACS diagnosis in the Danish National Patient Registry or the Cause of Death Registry. Diagnoses were verified through medical record review. In Cox proportional hazard models, we adjusted for established risk factors for CHD. Men in the four highest quintiles of n-3 PUFA intake (>0.39 g n-3 PUFA per d) had a lower incidence of ACS compared with men in the lowest quintile. The hazard ratio was 0.83 (95 % CI 0.67, 1.03) when we compared men in the second lowest and lowest quintile of n-3 PUFA intake. Higher intake of n-3 PUFA did not strengthen this association. Associations for EPA, DPA and DHA were all negative, but less consistent. No convincing associations were found among women. In conclusion, we found borderline significant negative associations between the intake of marine n-3 PUFA and ACS among healthy men. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/19825219/Dietary_intake_of_total_marine_n_3_polyunsaturated_fatty_acids_eicosapentaenoic_acid_docosahexaenoic_acid_and_docosapentaenoic_acid_and_the_risk_of_acute_coronary_syndrome___a_cohort_study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114509992170/type/journal_article DB - PRIME DP - Unbound Medicine ER -