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Neurodevelopmental factors associated with schizotypal symptoms among adolescents at risk for schizophrenia.
Dev Psychopathol. 2009 Fall; 21(4):1195-210.DP

Abstract

Schizophrenia has come to be viewed as a neurodevelopmental disorder that is characterized by genetic vulnerability, stressors during the prenatal period that may be marked by minor physical anomalies and neurobehavioral deficits that emerge in early development. Less is known about the neurodevelopmental origins of schizotypal personality symptoms. The present study examines schizotypal symptoms in Israeli adolescents (mean age = 16.79 years) who have not yet reached the developmental period during which first schizophrenic episode is most likely to emerge: 39 adolescent offspring of parents with schizophrenia, 39 offspring of parents with other psychiatric disorders, and 36 offspring of parents with no history of mental illness. The Semi-Structured Kiddie Interview for Personality Syndromes was used to assess cognitive-perceptual, interpersonal, and disorganized schizotypal symptoms. Interpersonal schizotypal symptoms were more prevalent in the schizophrenia offspring group than in the no-mental-illness offspring group. Among the schizophrenia offspring group, interpersonal, but not cognitive-perceptual, schizotypal symptoms were associated with minor physical anomalies, fine motor dyscoordination, and deficits in executive functioning during adolescence. Among young people whose parents did not have schizophrenia, cognitive-perceptual schizotypal symptoms were correlated with deficits in executive functioning. Adolescent schizotypal symptoms were associated with neurobehavioral symptoms measured during middle childhood in a subgroup of the sample that had been assessed prospectively. Finally, young people who had genetic risk for schizophrenia, minor physical anomalies, and neurobehavioral signs together were at markedly increased risk for symptoms of interpersonal schizotypal symptoms, compared to young people with one or none of these risk factors.

Authors+Show Affiliations

School of Social Service Administration, University of Chicago, 969 East 60th Street, Chicago, IL 60637, USA. shans@uchicago.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19825264

Citation

Hans, Sydney L., et al. "Neurodevelopmental Factors Associated With Schizotypal Symptoms Among Adolescents at Risk for Schizophrenia." Development and Psychopathology, vol. 21, no. 4, 2009, pp. 1195-210.
Hans SL, Auerbach JG, Nuechterlein KH, et al. Neurodevelopmental factors associated with schizotypal symptoms among adolescents at risk for schizophrenia. Dev Psychopathol. 2009;21(4):1195-210.
Hans, S. L., Auerbach, J. G., Nuechterlein, K. H., Asarnow, R. F., Asarnow, J., Styr, B., & Marcus, J. (2009). Neurodevelopmental factors associated with schizotypal symptoms among adolescents at risk for schizophrenia. Development and Psychopathology, 21(4), 1195-210. https://doi.org/10.1017/S0954579409990113
Hans SL, et al. Neurodevelopmental Factors Associated With Schizotypal Symptoms Among Adolescents at Risk for Schizophrenia. Dev Psychopathol. 2009;21(4):1195-210. PubMed PMID: 19825264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurodevelopmental factors associated with schizotypal symptoms among adolescents at risk for schizophrenia. AU - Hans,Sydney L, AU - Auerbach,Judith G, AU - Nuechterlein,Keith H, AU - Asarnow,Robert F, AU - Asarnow,Joan, AU - Styr,Benedict, AU - Marcus,Joseph, PY - 2009/10/15/entrez PY - 2009/10/15/pubmed PY - 2010/1/9/medline SP - 1195 EP - 210 JF - Development and psychopathology JO - Dev Psychopathol VL - 21 IS - 4 N2 - Schizophrenia has come to be viewed as a neurodevelopmental disorder that is characterized by genetic vulnerability, stressors during the prenatal period that may be marked by minor physical anomalies and neurobehavioral deficits that emerge in early development. Less is known about the neurodevelopmental origins of schizotypal personality symptoms. The present study examines schizotypal symptoms in Israeli adolescents (mean age = 16.79 years) who have not yet reached the developmental period during which first schizophrenic episode is most likely to emerge: 39 adolescent offspring of parents with schizophrenia, 39 offspring of parents with other psychiatric disorders, and 36 offspring of parents with no history of mental illness. The Semi-Structured Kiddie Interview for Personality Syndromes was used to assess cognitive-perceptual, interpersonal, and disorganized schizotypal symptoms. Interpersonal schizotypal symptoms were more prevalent in the schizophrenia offspring group than in the no-mental-illness offspring group. Among the schizophrenia offspring group, interpersonal, but not cognitive-perceptual, schizotypal symptoms were associated with minor physical anomalies, fine motor dyscoordination, and deficits in executive functioning during adolescence. Among young people whose parents did not have schizophrenia, cognitive-perceptual schizotypal symptoms were correlated with deficits in executive functioning. Adolescent schizotypal symptoms were associated with neurobehavioral symptoms measured during middle childhood in a subgroup of the sample that had been assessed prospectively. Finally, young people who had genetic risk for schizophrenia, minor physical anomalies, and neurobehavioral signs together were at markedly increased risk for symptoms of interpersonal schizotypal symptoms, compared to young people with one or none of these risk factors. SN - 1469-2198 UR - https://www.unboundmedicine.com/medline/citation/19825264/Neurodevelopmental_factors_associated_with_schizotypal_symptoms_among_adolescents_at_risk_for_schizophrenia_ L2 - https://www.cambridge.org/core/product/identifier/S0954579409990113/type/journal_article DB - PRIME DP - Unbound Medicine ER -