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The effect of potassium bromate on some haematological parameters of Wistar rats.
Niger J Physiol Sci. 2009 Jun; 24(1):59-61.NJ

Abstract

Potassium bromate used widely in foods has been associated with various complications in humans. However there is paucity of literature on adverse effects on haematological parameters. Thus we decided to carry out an experimental study to determine the effects of potassium bromate on some blood indices using Wistar rats. Twenty (20) male Wistar rats aged 2-3 months obtained from the department of Veterinary Medicine, University of Nigeria Nsukka were acclimatized for two weeks. They were divided into five groups and fed with graded doses of potassium bromate solution for six weeks. One of the groups served as the control. Pre and post administration blood samples were collected and analyzed the same day using standard methods. The results revealed significant [P<0.05] decrease in the platelet count when compared with the controls. There were no statistically significant differences in the mean cell haemoglobin concentration, haematocrit, and total leukocyte counts between the test and control rats. Potassium bromate is injurious to health if consumed continuously and in high quantity. It has been shown to reduce platelet count in rats, and thus may cause thrombocytopenia in humans. It is therefore imperative to take adequate measures to eliminate the use of potassium bromate in the preparation of food products.

Authors+Show Affiliations

Department of Medical Laboratory Sciences, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu Campus, and Department of Haematology, Neuropsychiatric Hospital Enugu, Nigeria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19826465

Citation

Achukwu, P U., et al. "The Effect of Potassium Bromate On some Haematological Parameters of Wistar Rats." Nigerian Journal of Physiological Sciences : Official Publication of the Physiological Society of Nigeria, vol. 24, no. 1, 2009, pp. 59-61.
Achukwu PU, Ufelle SA, Ukaejiofo EO, et al. The effect of potassium bromate on some haematological parameters of Wistar rats. Niger J Physiol Sci. 2009;24(1):59-61.
Achukwu, P. U., Ufelle, S. A., Ukaejiofo, E. O., Ejezie, F. E., Nwachukwu, D. N., Nwagha, U. I., Nworie, W. C., & Anyaehie, U. S. (2009). The effect of potassium bromate on some haematological parameters of Wistar rats. Nigerian Journal of Physiological Sciences : Official Publication of the Physiological Society of Nigeria, 24(1), 59-61.
Achukwu PU, et al. The Effect of Potassium Bromate On some Haematological Parameters of Wistar Rats. Niger J Physiol Sci. 2009;24(1):59-61. PubMed PMID: 19826465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of potassium bromate on some haematological parameters of Wistar rats. AU - Achukwu,P U, AU - Ufelle,S A, AU - Ukaejiofo,E O, AU - Ejezie,F E, AU - Nwachukwu,D N, AU - Nwagha,U I, AU - Nworie,W C, AU - Anyaehie,U S B, PY - 2009/10/15/entrez PY - 2009/10/15/pubmed PY - 2010/10/20/medline SP - 59 EP - 61 JF - Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria JO - Niger J Physiol Sci VL - 24 IS - 1 N2 - Potassium bromate used widely in foods has been associated with various complications in humans. However there is paucity of literature on adverse effects on haematological parameters. Thus we decided to carry out an experimental study to determine the effects of potassium bromate on some blood indices using Wistar rats. Twenty (20) male Wistar rats aged 2-3 months obtained from the department of Veterinary Medicine, University of Nigeria Nsukka were acclimatized for two weeks. They were divided into five groups and fed with graded doses of potassium bromate solution for six weeks. One of the groups served as the control. Pre and post administration blood samples were collected and analyzed the same day using standard methods. The results revealed significant [P<0.05] decrease in the platelet count when compared with the controls. There were no statistically significant differences in the mean cell haemoglobin concentration, haematocrit, and total leukocyte counts between the test and control rats. Potassium bromate is injurious to health if consumed continuously and in high quantity. It has been shown to reduce platelet count in rats, and thus may cause thrombocytopenia in humans. It is therefore imperative to take adequate measures to eliminate the use of potassium bromate in the preparation of food products. SN - 0794-859X UR - https://www.unboundmedicine.com/medline/citation/19826465/The_effect_of_potassium_bromate_on_some_haematological_parameters_of_Wistar_rats_ DB - PRIME DP - Unbound Medicine ER -