Tags

Type your tag names separated by a space and hit enter

Propionyl l-carnitine: intermittent claudication and peripheral arterial disease.
Expert Opin Pharmacother. 2009 Nov; 10(16):2697-707.EO

Abstract

Peripheral arterial disease (PAD) is a clinical manifestation of underlying aorto-iliac and leg atherosclerosis that is characterized by different stages of stenosis and obstruction. It affects approximately 12% of the adult population and about 20% of people over the age of 70 years, and is associated with increased cardiovascular (CV) and cerebrovascular morbidity. Intermittent claudication (IC) is the major symptom of PAD; it is defined as cramping leg pain (in the buttock, thigh, or calf) while/after clim bing one or two flights of stairs, or during walking. The goals of IC management are to: slow the progression of local and systemic atherosclerosis, prevent major fatal and nonfatal CV events (myocardial infarction and stroke), improve walking capacity, prevent and reduce resting pain and cutaneous lesions. Propionyl L-carnitine is an acyl derivative of levocarnitine (L-carnitine) and is indicated for patients with peripheral arterial occlusive disease. It corrects secondary muscle carnitine deficiency in patients with PAD, significantly improving the walking capacity; it is a free radical that produces positive effects on endothelial function; it protects from oxidative stress; and it enhances most measures of quality of life. The recent Trans-Atlantic Inter-Society Consensus II update recommends the use of propionyl L-carnitine in combination with physical training to improve the symptoms associated with PAD.

Authors+Show Affiliations

University Hospital, Angiology Care Unit, via Giustiniani 2, Padua 35128, Italy. gm.andreozzi@angio-pd.it

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19827991

Citation

Andreozzi, G M.. "Propionyl L-carnitine: Intermittent Claudication and Peripheral Arterial Disease." Expert Opinion On Pharmacotherapy, vol. 10, no. 16, 2009, pp. 2697-707.
Andreozzi GM. Propionyl l-carnitine: intermittent claudication and peripheral arterial disease. Expert Opin Pharmacother. 2009;10(16):2697-707.
Andreozzi, G. M. (2009). Propionyl l-carnitine: intermittent claudication and peripheral arterial disease. Expert Opinion On Pharmacotherapy, 10(16), 2697-707. https://doi.org/10.1517/14656560903215871
Andreozzi GM. Propionyl L-carnitine: Intermittent Claudication and Peripheral Arterial Disease. Expert Opin Pharmacother. 2009;10(16):2697-707. PubMed PMID: 19827991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Propionyl l-carnitine: intermittent claudication and peripheral arterial disease. A1 - Andreozzi,G M, PY - 2009/10/16/entrez PY - 2009/10/16/pubmed PY - 2010/1/26/medline SP - 2697 EP - 707 JF - Expert opinion on pharmacotherapy JO - Expert Opin Pharmacother VL - 10 IS - 16 N2 - Peripheral arterial disease (PAD) is a clinical manifestation of underlying aorto-iliac and leg atherosclerosis that is characterized by different stages of stenosis and obstruction. It affects approximately 12% of the adult population and about 20% of people over the age of 70 years, and is associated with increased cardiovascular (CV) and cerebrovascular morbidity. Intermittent claudication (IC) is the major symptom of PAD; it is defined as cramping leg pain (in the buttock, thigh, or calf) while/after clim bing one or two flights of stairs, or during walking. The goals of IC management are to: slow the progression of local and systemic atherosclerosis, prevent major fatal and nonfatal CV events (myocardial infarction and stroke), improve walking capacity, prevent and reduce resting pain and cutaneous lesions. Propionyl L-carnitine is an acyl derivative of levocarnitine (L-carnitine) and is indicated for patients with peripheral arterial occlusive disease. It corrects secondary muscle carnitine deficiency in patients with PAD, significantly improving the walking capacity; it is a free radical that produces positive effects on endothelial function; it protects from oxidative stress; and it enhances most measures of quality of life. The recent Trans-Atlantic Inter-Society Consensus II update recommends the use of propionyl L-carnitine in combination with physical training to improve the symptoms associated with PAD. SN - 1744-7666 UR - https://www.unboundmedicine.com/medline/citation/19827991/Propionyl_l_carnitine:_intermittent_claudication_and_peripheral_arterial_disease_ L2 - https://www.tandfonline.com/doi/full/10.1517/14656560903215871 DB - PRIME DP - Unbound Medicine ER -