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Diabetic patients on CAPD need less aluminum hydroxide as a phosphate binder than non-diabetics.
Adv Perit Dial. 1990; 6:50-2.AP

Abstract

A retrospective study was done in 86 patients on dialysis in order to evaluate the doses of aluminum hydroxide (OH3 Al) received to achieve a better serum phosphate control. Thirty-seven patients were treated with continuous ambulatory peritoneal dialysis (CAPD) divided in 22 diabetics and 15 non-diabetics. Forty-nine patients were treated with hemodialysis (HD), 12 diabetics and 37 non-diabetics. The doses of 1-25 Dihidroxycholecalciferol (1-25 DOH-D3) were similar in all patients. The serum phosphate levels were similar in CAPD and HD patients with smaller doses of OH3 AL in CAPD patients (p less than 0.001). Diabetics on either technique need less OH3 AL in CAPD (CAPD p less than 0.01; HD p less than 0.05) to achieve the same or better control of serum phosphorus than non-diabetics. The overload of glucose on CAPD and the maintained hyperglycemia on diabetes mellitus would shift phosphorus into the cell and could explain these results. Finally, the less needs of aluminum hydroxide on diabetic patients could contribute to their protection against aluminum deposition and its effects.

Authors+Show Affiliations

Nephrology Department, Hospital Universitario, San Carlos, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1982839

Citation

Macia, M, et al. "Diabetic Patients On CAPD Need Less Aluminum Hydroxide as a Phosphate Binder Than Non-diabetics." Advances in Peritoneal Dialysis. Conference On Peritoneal Dialysis, vol. 6, 1990, pp. 50-2.
Macia M, Coronel F, Torrente J, et al. Diabetic patients on CAPD need less aluminum hydroxide as a phosphate binder than non-diabetics. Adv Perit Dial. 1990;6:50-2.
Macia, M., Coronel, F., Torrente, J., Sanchez, A., Tornero, F., & Barrientos, A. (1990). Diabetic patients on CAPD need less aluminum hydroxide as a phosphate binder than non-diabetics. Advances in Peritoneal Dialysis. Conference On Peritoneal Dialysis, 6, 50-2.
Macia M, et al. Diabetic Patients On CAPD Need Less Aluminum Hydroxide as a Phosphate Binder Than Non-diabetics. Adv Perit Dial. 1990;6:50-2. PubMed PMID: 1982839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetic patients on CAPD need less aluminum hydroxide as a phosphate binder than non-diabetics. AU - Macia,M, AU - Coronel,F, AU - Torrente,J, AU - Sanchez,A, AU - Tornero,F, AU - Barrientos,A, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 50 EP - 2 JF - Advances in peritoneal dialysis. Conference on Peritoneal Dialysis JO - Adv Perit Dial VL - 6 N2 - A retrospective study was done in 86 patients on dialysis in order to evaluate the doses of aluminum hydroxide (OH3 Al) received to achieve a better serum phosphate control. Thirty-seven patients were treated with continuous ambulatory peritoneal dialysis (CAPD) divided in 22 diabetics and 15 non-diabetics. Forty-nine patients were treated with hemodialysis (HD), 12 diabetics and 37 non-diabetics. The doses of 1-25 Dihidroxycholecalciferol (1-25 DOH-D3) were similar in all patients. The serum phosphate levels were similar in CAPD and HD patients with smaller doses of OH3 AL in CAPD patients (p less than 0.001). Diabetics on either technique need less OH3 AL in CAPD (CAPD p less than 0.01; HD p less than 0.05) to achieve the same or better control of serum phosphorus than non-diabetics. The overload of glucose on CAPD and the maintained hyperglycemia on diabetes mellitus would shift phosphorus into the cell and could explain these results. Finally, the less needs of aluminum hydroxide on diabetic patients could contribute to their protection against aluminum deposition and its effects. SN - 1197-8554 UR - https://www.unboundmedicine.com/medline/citation/1982839/Diabetic_patients_on_CAPD_need_less_aluminum_hydroxide_as_a_phosphate_binder_than_non_diabetics_ L2 - https://medlineplus.gov/diabetickidneyproblems.html DB - PRIME DP - Unbound Medicine ER -