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Long-term renal function after allogenic haematopoietic stem cell transplantation in adult patients: a single-centre study.
Nephrol Dial Transplant. 2010 Feb; 25(2):624-7.ND

Abstract

BACKGROUND

Reported data regarding chronic kidney disease (CKD) in haematopoietic stem cells transplantation (HSCT) recipients are highly discrepant. Materials and methods. We undertook a retrospective single-centre study in order to assess the rate, risk factors and outcome of HSCT-associated CKD in 123 allogeneic HSCT patients.

RESULTS

Twenty-four months after HSCT, CKD [e.g. glomerular filtration rate (GFR) estimated using the MDRD formula <60 ml/min/1.73 m(2)] was noted in 49 patients (40%). Age >or= 45 years, early acute kidney injury and a baseline GFR < 90 ml/min/1.73 m(2) predicted the occurrence of CKD at 24 months after HSCT. One hundred and six patients (45 with and 61 without CKD at 24 months) were followed up for more than 36 months (range 36-142). Among the 45 patients with CKD at 24 months after HSCT, CKD persisted in 30 (67%), 10 patients (22%) showed a transient improvement in GFR but retained CKD and 10 patients (22%) had a sustained improvement of GFR. Among 61 patients without CKD at 24 months after HSCT, 3 (5%) developed CKD during the follow-up. Our data indicate that HSCT-related CKD probably includes two subsets: a frequent early-onset CKD, a consequence of ARF in older patients with pre-existent renal impairment, and a rare late-onset CKD occurring more than 2 years following HSCT.

CONCLUSIONS

Careful monitoring of renal function is mandatory in patients undergoing HSCT, especially old patients with pre-existent renal impairment.

Authors+Show Affiliations

Department of Nephrology, Université Paris Descartes, AP-HP, Necker Hospital, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19828460

Citation

Touzot, Maxime, et al. "Long-term Renal Function After Allogenic Haematopoietic Stem Cell Transplantation in Adult Patients: a Single-centre Study." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 25, no. 2, 2010, pp. 624-7.
Touzot M, Elie C, van Massenhove J, et al. Long-term renal function after allogenic haematopoietic stem cell transplantation in adult patients: a single-centre study. Nephrol Dial Transplant. 2010;25(2):624-7.
Touzot, M., Elie, C., van Massenhove, J., Maillard, N., Buzyn, A., & Fakhouri, F. (2010). Long-term renal function after allogenic haematopoietic stem cell transplantation in adult patients: a single-centre study. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 25(2), 624-7. https://doi.org/10.1093/ndt/gfp529
Touzot M, et al. Long-term Renal Function After Allogenic Haematopoietic Stem Cell Transplantation in Adult Patients: a Single-centre Study. Nephrol Dial Transplant. 2010;25(2):624-7. PubMed PMID: 19828460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term renal function after allogenic haematopoietic stem cell transplantation in adult patients: a single-centre study. AU - Touzot,Maxime, AU - Elie,Caroline, AU - van Massenhove,Jill, AU - Maillard,Natacha, AU - Buzyn,Agnès, AU - Fakhouri,Fadi, Y1 - 2009/10/13/ PY - 2009/10/16/entrez PY - 2009/10/16/pubmed PY - 2010/5/21/medline SP - 624 EP - 7 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 25 IS - 2 N2 - BACKGROUND: Reported data regarding chronic kidney disease (CKD) in haematopoietic stem cells transplantation (HSCT) recipients are highly discrepant. Materials and methods. We undertook a retrospective single-centre study in order to assess the rate, risk factors and outcome of HSCT-associated CKD in 123 allogeneic HSCT patients. RESULTS: Twenty-four months after HSCT, CKD [e.g. glomerular filtration rate (GFR) estimated using the MDRD formula <60 ml/min/1.73 m(2)] was noted in 49 patients (40%). Age >or= 45 years, early acute kidney injury and a baseline GFR < 90 ml/min/1.73 m(2) predicted the occurrence of CKD at 24 months after HSCT. One hundred and six patients (45 with and 61 without CKD at 24 months) were followed up for more than 36 months (range 36-142). Among the 45 patients with CKD at 24 months after HSCT, CKD persisted in 30 (67%), 10 patients (22%) showed a transient improvement in GFR but retained CKD and 10 patients (22%) had a sustained improvement of GFR. Among 61 patients without CKD at 24 months after HSCT, 3 (5%) developed CKD during the follow-up. Our data indicate that HSCT-related CKD probably includes two subsets: a frequent early-onset CKD, a consequence of ARF in older patients with pre-existent renal impairment, and a rare late-onset CKD occurring more than 2 years following HSCT. CONCLUSIONS: Careful monitoring of renal function is mandatory in patients undergoing HSCT, especially old patients with pre-existent renal impairment. SN - 1460-2385 UR - https://www.unboundmedicine.com/medline/citation/19828460/Long_term_renal_function_after_allogenic_haematopoietic_stem_cell_transplantation_in_adult_patients:_a_single_centre_study_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfp529 DB - PRIME DP - Unbound Medicine ER -