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Postmenopausal breast cancer risk and dietary patterns in the E3N-EPIC prospective cohort study.

Abstract

Since evidence relating diet to breast cancer risk is not sufficiently consistent to elaborate preventive proposals, the authors examined the association between dietary patterns and breast cancer risk in a large French cohort study. The analyses included 2,381 postmenopausal invasive breast cancer cases diagnosed during a median 9.7-year follow-up period (1993-2005) among 65,374 women from the E3N-EPIC cohort. Scores for dietary patterns were obtained by factor analysis, and breast cancer hazard ratios were estimated by Cox proportional hazards regression for the highest quartile of dietary pattern score versus the lowest. Two dietary patterns were identified: "alcohol/Western" (essentially meat products, French fries, appetizers, rice/pasta, potatoes, pulses, pizza/pies, canned fish, eggs, alcoholic beverages, cakes, mayonnaise, and butter/cream) and "healthy/Mediterranean" (essentially vegetables, fruits, seafood, olive oil, and sunflower oil). The first pattern was positively associated with breast cancer risk (hazard ratio = 1.20, 95% confidence interval (CI): 1.03, 1.38; P = 0.007 for linear trend), especially when tumors were estrogen receptor-positive/progesterone receptor-positive. The "healthy/Mediterranean" pattern was negatively associated with breast cancer risk (hazard ratio = 0.85, 95% CI: 0.75, 0.95; P = 0.003 for linear trend), especially when tumors were estrogen receptor-positive/progesterone receptor-negative. Adherence to a diet comprising mostly fruits, vegetables, fish, and olive/sunflower oil, along with avoidance of Western-type foods, may contribute to a substantial reduction in postmenopausal breast cancer risk.

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  • Authors+Show Affiliations

    ,

    Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe Région INSERM 20, Institut de Cancérologie Gustave Roussy, Villejuif, France.

    , , , , ,

    Source

    American journal of epidemiology 170:10 2009 Nov 15 pg 1257-67

    MeSH

    Aged
    Aged, 80 and over
    Breast Neoplasms
    Cohort Studies
    Confidence Intervals
    Diet
    Factor Analysis, Statistical
    Female
    France
    Humans
    Life Style
    Middle Aged
    Nutritional Status
    Postmenopause
    Proportional Hazards Models
    Prospective Studies
    Qualitative Research
    Receptors, Estrogen
    Risk Assessment
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19828509

    Citation

    Cottet, Vanessa, et al. "Postmenopausal Breast Cancer Risk and Dietary Patterns in the E3N-EPIC Prospective Cohort Study." American Journal of Epidemiology, vol. 170, no. 10, 2009, pp. 1257-67.
    Cottet V, Touvier M, Fournier A, et al. Postmenopausal breast cancer risk and dietary patterns in the E3N-EPIC prospective cohort study. Am J Epidemiol. 2009;170(10):1257-67.
    Cottet, V., Touvier, M., Fournier, A., Touillaud, M. S., Lafay, L., Clavel-Chapelon, F., & Boutron-Ruault, M. C. (2009). Postmenopausal breast cancer risk and dietary patterns in the E3N-EPIC prospective cohort study. American Journal of Epidemiology, 170(10), pp. 1257-67. doi:10.1093/aje/kwp257.
    Cottet V, et al. Postmenopausal Breast Cancer Risk and Dietary Patterns in the E3N-EPIC Prospective Cohort Study. Am J Epidemiol. 2009 Nov 15;170(10):1257-67. PubMed PMID: 19828509.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Postmenopausal breast cancer risk and dietary patterns in the E3N-EPIC prospective cohort study. AU - Cottet,Vanessa, AU - Touvier,Mathilde, AU - Fournier,Agnès, AU - Touillaud,Marina S, AU - Lafay,Lionel, AU - Clavel-Chapelon,Françoise, AU - Boutron-Ruault,Marie-Christine, Y1 - 2009/10/14/ PY - 2009/10/16/entrez PY - 2009/10/16/pubmed PY - 2009/11/18/medline SP - 1257 EP - 67 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 170 IS - 10 N2 - Since evidence relating diet to breast cancer risk is not sufficiently consistent to elaborate preventive proposals, the authors examined the association between dietary patterns and breast cancer risk in a large French cohort study. The analyses included 2,381 postmenopausal invasive breast cancer cases diagnosed during a median 9.7-year follow-up period (1993-2005) among 65,374 women from the E3N-EPIC cohort. Scores for dietary patterns were obtained by factor analysis, and breast cancer hazard ratios were estimated by Cox proportional hazards regression for the highest quartile of dietary pattern score versus the lowest. Two dietary patterns were identified: "alcohol/Western" (essentially meat products, French fries, appetizers, rice/pasta, potatoes, pulses, pizza/pies, canned fish, eggs, alcoholic beverages, cakes, mayonnaise, and butter/cream) and "healthy/Mediterranean" (essentially vegetables, fruits, seafood, olive oil, and sunflower oil). The first pattern was positively associated with breast cancer risk (hazard ratio = 1.20, 95% confidence interval (CI): 1.03, 1.38; P = 0.007 for linear trend), especially when tumors were estrogen receptor-positive/progesterone receptor-positive. The "healthy/Mediterranean" pattern was negatively associated with breast cancer risk (hazard ratio = 0.85, 95% CI: 0.75, 0.95; P = 0.003 for linear trend), especially when tumors were estrogen receptor-positive/progesterone receptor-negative. Adherence to a diet comprising mostly fruits, vegetables, fish, and olive/sunflower oil, along with avoidance of Western-type foods, may contribute to a substantial reduction in postmenopausal breast cancer risk. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/19828509/Postmenopausal_breast_cancer_risk_and_dietary_patterns_in_the_E3N_EPIC_prospective_cohort_study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp257 DB - PRIME DP - Unbound Medicine ER -