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The current status of gastric prokinetic drugs.
Acta Gastroenterol Belg 1990 Jul-Aug; 53(4):446-57AG

Abstract

Several current gastrokinetic drugs (metoclopramide, domperidone, cisapride) are analysed in this review. After comparing the pharmacokinetics, the gastrointestinal prokinetic mechanisms and the side effects of each drug, their therapeutic uses are reviewed. All drugs improve symptoms of patients with gastro-oesophageal reflux disease, diabetic gastroparesis and idiopathic gastroparesis, but only cisapride seems capable to maintain a gastrokinetic effect under chronic administration. Erythromycin, which has a dramatic effect on hypomotility in diabetic gastroparesis, and opioid antagonists, may constitute new groups of efficient prokinetic drugs.

Authors+Show Affiliations

Service de Médecine Interne, Clinique de Jolimont, Haine-St-Paul, Belgique.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

1982914

Citation

Schapira, M, et al. "The Current Status of Gastric Prokinetic Drugs." Acta Gastro-enterologica Belgica, vol. 53, no. 4, 1990, pp. 446-57.
Schapira M, Henrion J, Heller FR. The current status of gastric prokinetic drugs. Acta Gastroenterol Belg. 1990;53(4):446-57.
Schapira, M., Henrion, J., & Heller, F. R. (1990). The current status of gastric prokinetic drugs. Acta Gastro-enterologica Belgica, 53(4), pp. 446-57.
Schapira M, Henrion J, Heller FR. The Current Status of Gastric Prokinetic Drugs. Acta Gastroenterol Belg. 1990;53(4):446-57. PubMed PMID: 1982914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The current status of gastric prokinetic drugs. AU - Schapira,M, AU - Henrion,J, AU - Heller,F R, PY - 1990/7/1/pubmed PY - 1990/7/1/medline PY - 1990/7/1/entrez SP - 446 EP - 57 JF - Acta gastro-enterologica Belgica JO - Acta Gastroenterol. Belg. VL - 53 IS - 4 N2 - Several current gastrokinetic drugs (metoclopramide, domperidone, cisapride) are analysed in this review. After comparing the pharmacokinetics, the gastrointestinal prokinetic mechanisms and the side effects of each drug, their therapeutic uses are reviewed. All drugs improve symptoms of patients with gastro-oesophageal reflux disease, diabetic gastroparesis and idiopathic gastroparesis, but only cisapride seems capable to maintain a gastrokinetic effect under chronic administration. Erythromycin, which has a dramatic effect on hypomotility in diabetic gastroparesis, and opioid antagonists, may constitute new groups of efficient prokinetic drugs. SN - 1784-3227 UR - https://www.unboundmedicine.com/medline/citation/1982914/The_current_status_of_gastric_prokinetic_drugs_ L2 - https://www.lens.org/lens/search?q=citation_id:1982914 DB - PRIME DP - Unbound Medicine ER -