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Antifungal activity of Eugenia umbelliflora against dermatophytes.
Nat Prod Commun. 2009 Sep; 4(9):1181-4.NP

Abstract

Antifungal activities of Eugenia umbelliflora Berg. (Myrtaceae) were tested in vitro against a panel of standard and clinical isolates of human fungal pathogens (dermatophytes and opportunistic saprobes). Methanol extracts of leaves and fruits of E. umbelliflora were separately prepared and partitioned, to yield dichloromethane (DCM), ethyl acetate (EtOAc) and aqueous fractions (Aq). Three compounds (1-3) were obtained from the DCM extract using chromatographic procedures. Antifungal assays were performed using agar dilution techniques. Both extracts (fruits and leaves), their DCM and EtOAc fractions, and compound 2 (betulin and betulinic acid) presented selective antifungal activity against dermatophytes (Epidermophyton floccosum, Microsporum canis, Microsporum gypseum, Trichophyton rubrum, Trichophyton mentagrophytes), with MIC values between 200 and 1000 microg/mL, and interestingly, inhibited 4/5 species with MIC values of < or = 500 microg/mL. The aqueous fractions of fruits and leaves, and compounds 1 (alpha, beta amyrin) and 3 (taraxerol) were inactive up to the maximum concentrations tested (1000 microg/mL).

Authors+Show Affiliations

Machado KE
Programa de Mestrado em Ciências Farmacêuticas/CCS Universidade do Vale do Itajaí (UNIVALI), Rua Uruguai, 458, 88.302-202, Itajaí, SC, Brazil.
Cechinel Filho V
No affiliation info available
Cruz RC
No affiliation info available
Meyre-Silva C
No affiliation info available
Cruz AB
No affiliation info available

MeSH

Antifungal AgentsArthrodermataceaeChromatography, GasChromatography, GelDermatomycosesFruitHumansMicrobial Sensitivity TestsPlant ExtractsPlant LeavesSyzygiumTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19831024

Citation

Machado, Karina E., et al. "Antifungal Activity of Eugenia Umbelliflora Against Dermatophytes." Natural Product Communications, vol. 4, no. 9, 2009, pp. 1181-4.
Machado KE, Cechinel Filho V, Cruz RC, et al. Antifungal activity of Eugenia umbelliflora against dermatophytes. Nat Prod Commun. 2009;4(9):1181-4.
Machado, K. E., Cechinel Filho, V., Cruz, R. C., Meyre-Silva, C., & Cruz, A. B. (2009). Antifungal activity of Eugenia umbelliflora against dermatophytes. Natural Product Communications, 4(9), 1181-4.
Machado KE, et al. Antifungal Activity of Eugenia Umbelliflora Against Dermatophytes. Nat Prod Commun. 2009;4(9):1181-4. PubMed PMID: 19831024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal activity of Eugenia umbelliflora against dermatophytes. AU - Machado,Karina E, AU - Cechinel Filho,Valdir, AU - Cruz,Rosana C B, AU - Meyre-Silva,Christiane, AU - Cruz,Alexandre Bella, PY - 2009/10/17/entrez PY - 2009/10/17/pubmed PY - 2009/12/16/medline SP - 1181 EP - 4 JF - Natural product communications JO - Nat Prod Commun VL - 4 IS - 9 N2 - Antifungal activities of Eugenia umbelliflora Berg. (Myrtaceae) were tested in vitro against a panel of standard and clinical isolates of human fungal pathogens (dermatophytes and opportunistic saprobes). Methanol extracts of leaves and fruits of E. umbelliflora were separately prepared and partitioned, to yield dichloromethane (DCM), ethyl acetate (EtOAc) and aqueous fractions (Aq). Three compounds (1-3) were obtained from the DCM extract using chromatographic procedures. Antifungal assays were performed using agar dilution techniques. Both extracts (fruits and leaves), their DCM and EtOAc fractions, and compound 2 (betulin and betulinic acid) presented selective antifungal activity against dermatophytes (Epidermophyton floccosum, Microsporum canis, Microsporum gypseum, Trichophyton rubrum, Trichophyton mentagrophytes), with MIC values between 200 and 1000 microg/mL, and interestingly, inhibited 4/5 species with MIC values of < or = 500 microg/mL. The aqueous fractions of fruits and leaves, and compounds 1 (alpha, beta amyrin) and 3 (taraxerol) were inactive up to the maximum concentrations tested (1000 microg/mL). SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/19831024/Antifungal_activity_of_Eugenia_umbelliflora_against_dermatophytes_ DB - PRIME DP - Unbound Medicine ER -